Lycium barbarum (Goji) : medicinal properties in alcoholic extraction

Lycium barbarum (Goji) — family Solanacées.

Scientific synonyms : Lycium halimifolium Mill., L trewianum Roem. & Schult., L turbinatum Loisel., L vulgare Dunal, Teremis elliptica Raf., Jasminoides flaccida Moench, Lycium floridum Salisb..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 87 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of carcinoma: liver, oral, breast

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ceccarini MR (2016)

     Excerpt In particular, downexpression of genes involved in tumor migration & invasion (CCL5), in increased risk of metastasis & antiapoptotic signal (DUSP1), & in carcinogenesis (GPx-3 and PTGS1), together with overexpression of tumor suppressor gene (MT3), suggested that Umbrian LB berries could play a protective role against hepatocellular carcinoma. The properties of LB berries cultivated in Umbria (Italy) & their effect on human hepatocellular carcinoma cells (HepG2) have been investigated in this work.

   • According to CUI B (2011)

     Excerpt This study evaluated the protective effects of aqueous extract of Lycium barbarum (LBAE) & ethanol extract of Lycium barbarum (LBEE) on blood lipid levels, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) activities liver tissue antioxidant enzyme activities in rats fed a high fat diet (HF). Rats fed the HF diet alone showed increased hepatocellular enzyme activities in plasma, a significant decline in antioxidant enzyme activities, & elevated liver lipid peroxidation indices.

   • According to Li D (2023)

     Excerpt Lycium barbarum polysaccharides (LBPs) have been shown to exert an antiglycemic effect.

   • According to Sanghavi A (2012)

     Excerpt It has also shown good anti-cancer properties & has been tested against liver, colon, prostate, breast, & cervical cancers. Hence goji berry can be tried as a potential anticancer agent to manage oral squamous cell carcinoma.

   • According to Amagase H (2011)

     Excerpt Lycium barbarum has been used as a traditional Chinese medicine (TCM) to nourish liver & kidney, & brighten the eye. LB on aging, neuroprotection, general well-being, fatigue/endurance, metabolism/energy expenditure, glucose control in diabetics, glaucoma, anti-oxidant properties, immunomodulation, anti-tumor activity & cytoprotection.

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Liu H (2022)

     Excerpt Lycium barbarum polysaccharides, polyphenols, carotenoids & amino acids are the major natural bioactive compounds in the fruits of LB They have many physiological activities & medicinal values & have shown significant anti-diabetic effects. The fruits of Lycium barbarum, an ancient tonic and a traditional Chinese medicine, have shown beneficial effects against chronic metabolic diseases.

   • According to Luo O (2004)

     Excerpt The hypoglycemic & hypolipidemic effects of Lycium barbarum fruit water decoction, crude polysaccharide extracts (crude LBP), & purified polysaccharide fractions (LBP-X) in alloxan-induced diabetic or hyperlipidemic rabbits were investigated through designed sequential trials & by measuring blood glucose & serum lipid parameters. It was found that the three LB fruit extracts/fractions could significantly reduce blood glucose levels & serum total cholesterol (TC) & triglyceride (TG) concentrations and at same time markedly increase high density lipoprotein cholesterol (HDL-c) levels after 10 days treatment in tested rabbits, indicating that there were substantial hypoglycemic & hypolipidemic effects.

   • According to Quan N (2023)

     Excerpt Ultrasound–microwave combined extraction (UMCE), gradient ethanol precipitation, chemical characterization, & antioxidant & hypoglycemic activities of Lycium barbarum leaf polysaccharides (LLP) were systematically studied. Among the three fractions, LLP30 possessed relatively high antioxidant & hypoglycemic activities in vitro, which showed a potential for becoming a nutraceutical or a phytopharmaceutical for prevention & treatment of hyperglycemia or diabetes.

   • According to Masci A (2018)

     Excerpt In the last decades, glycoconjugates from Lycium barbarum L. The evidence suggests that these purified components of the Goji berry may be potentially useful as adjuvants in the treatment of diabetes & its correlated illnesses.

   • According to Sharifi-Rad J (2024)

     Excerpt The present review focuses on the research evidence related to the therapeutic properties of Lycium barbarum L. It has been seen how a healthy lifestyle & good dietary practices are key to improving the different metabolic parameters &, therefore, play a fundamental role in reducing the risk of developing diabetes.

3. 3

   Tooth decay, dental plaque, periodontitis: S. mutans & P. gingivalis

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Soesanto S (2021)

     Excerpt These results indicate that ethanol extract of LB fruit was demonstrated to have antibacterial & antibiofilm effects against oral pathogens S. The objective of this study is to determine the antibacterial & the antibiofilm effects of LB fruit ethanol extract towards S.

   • According to SANGHAVI A (2023)

     Excerpt Removal of the microbial deposits (plaque & calculus) by performing effective scaling & root planing (SRP) is the fundamental step for managing periodontal disease (gingivitis & periodontitis). Hence the present study aims to evaluate the efficacy of goji berry mouthwash compared to chlorhexidine mouthwash for managing periodontitis.

   • According to Sanghavi A (2012)

     Excerpt barbarum), popularly referred to as Goji berry, is a promising herb known for its powerful anti-antioxidant, antibacterial, & anti-inflammatory properties. Hence goji berry can be tried as a potential anticancer agent to manage oral squamous cell carcinoma.

   • According to Skenderidis P (2019)

     Excerpt The present study aimed at assessing the antimicrobial properties of a water & ethanol ultrasound-assisted extraction (UAE) of dry goji berries & of lyophilised powdered pomegranate peel in vitro. Minimum inhibitory concentration (MIC) & minimal bactericidal concentration (MBC) methods, turbidity (cell density) measurement, & well diffusion assay were used to determine the antimicrobial activity against several species of foodborne bacteria (Gram–, Escherichia coli, Salmonella typhimurium, Campylobacter jejuni),(Gram-+Staphylococcus aureus, Listeria monocytogenes, Clostridium perfringens), yeasts (Yar&ia lipolytica, Metschinokowia fructicola, & Rhodotorula miucilaginosa) & fungi (oenicimmum expansum, Aspergillus niger, Fusarium oxysporum & Rhizoctonia solani).

   • According to Cheng J (2014)

     Excerpt Lycium barbarum berries, also named wolfberry, Fructus lycii, & Goji berries, have been used in the People's Republic of China & other Asian countries for more than 2,000 years as a traditional medicinal herb & food supplement. barbarum berries & have been reported to possess a wide array of pharmacological activities.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.