Manilkara zapota (Sapotiy) : medicinal properties in alcoholic extraction

Manilkara zapota (Sapotiy, Sapotille) — family Sapotacées.

Scientific synonyms : Achras zapota-L, Calocarpum mammosum-Pierre, Lucuma mammosa-CF Gaertn, Pouteria mammosa-Cronquist.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 35 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Neuropathic pain in people with diabetes

   Plant part used: stem bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Karie PP (2022)

     Excerpt A perusal of the literature suggested that Manilkara zapota stem bark (MZSB) is enriched with several bioactive phytoconstituents but had not been yet screened for its in vitro & in vivo antidiabetic potentials. Thus, the present study aimed to investigate the effects of 70% ethanolic extract of MZ stem bark (EMZSB) in DPPH- and H2O2-scavenging assay, in vitro α-glucosidase inhibition assay, ameliorating diabetes & its complications in alloxan-induced diabetes in Wistar rats.

   • According to Karie PP (2022)

     Excerpt However, for evaluating antidiabetic effects of fractions (chloroform, acetone, ethyl acetate, & remaining ethanol fraction) of EMZFP, diabetes was induced by streptozotocin (60 mg kg-1)-nicotinamide (120 mg kg-1/ml) in differently grouped male rats (n=6). Diabetic rats were treated with EMZFP fractions 200 mg kg-1 however; Glibenclamide (10 mg kg-1) was a reference standard & evaluated for blood glucose, serum lipids, cardiovascular risk indices, & diabetic neuropathy.

   • According to Rivas-Gastelum M.F (2023)

     Excerpt Manilkara zapota “chicozapote” is an autochthonous evergreen tree from the Southern regions of Mexico, Belize, & Guatemala. These bioactive compounds exert several biological activities, i.e., as an antioxidant, antidiabetic, antimicrobial, anti-inflammatory, cytotoxic, & anti- arthritic agents, to name a few.

   • According to Barbalho SM (2015)

     Excerpt zapota leaf juice or fruit juice, after which their biochemical & body composition profiles were analyzed (glycemia, triglycerides, high-density lipoprotein cholesterol (HDL-c), insulin, leptin, aspartate transaminase, alanine aminotransferase, Lee Index, & body mass index). Manilkara zapota is a tropical evergreen tree belonging to the Sapotaceae family; its parts are used in alternative medicine to treat coughs & colds & possess diuretic, antidiarrheal, antibiotic, antihyperglycemic, & hypocholesterolemic effects.

   • According to DZIB-GUERRA WC (2016)

     Excerpt Objective: to test ethanolic extracts & aqueous-traditional preparations of plants used to treat diabetes, hypertension & obesity in Yucatecan traditional medicine for their anti-AGE & free radical scavenging activities. Formation & accumulation of advanced glycation end-products (AGE) is recognized as a major pathogenic process in diabetic complications, atherosclerosis & cardiovascular diseases.

2. 2

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Karie PP (2022)

     Excerpt However, for evaluating antidiabetic effects of fractions (chloroform, acetone, ethyl acetate, & remaining ethanol fraction) of EMZFP, diabetes was induced by streptozotocin (60 mg kg-1)-nicotinamide (120 mg kg-1/ml) in differently grouped male rats (n=6). Methods: Antidiabetic effects of EMZFP were assessed in alloxan (150 mg kg-1) induced diabetes in differently grouped rats (n=6).

   • According to Karie PP (2022)

     Excerpt A perusal of the literature suggested that Manilkara zapota stem bark (MZSB) is enriched with several bioactive phytoconstituents but had not been yet screened for its in vitro & in vivo antidiabetic potentials. Thus, the present study aimed to investigate the effects of 70% ethanolic extract of MZ stem bark (EMZSB) in DPPH- and H2O2-scavenging assay, in vitro α-glucosidase inhibition assay, ameliorating diabetes & its complications in alloxan-induced diabetes in Wistar rats.

   • According to Barbalho SM (2015)

     Excerpt zapota leaf juice or fruit juice, after which their biochemical & body composition profiles were analyzed (glycemia, triglycerides, high-density lipoprotein cholesterol (HDL-c), insulin, leptin, aspartate transaminase, alanine aminotransferase, Lee Index, & body mass index). Manilkara zapota is a tropical evergreen tree belonging to the Sapotaceae family; its parts are used in alternative medicine to treat coughs & colds & possess diuretic, antidiarrheal, antibiotic, antihyperglycemic, & hypocholesterolemic effects.

   • According to Rivas-Gastelum M.F (2023)

     Excerpt Manilkara zapota “chicozapote” is an autochthonous evergreen tree from the Southern regions of Mexico, Belize, & Guatemala. These bioactive compounds exert several biological activities, i.e., as an antioxidant, antidiabetic, antimicrobial, anti-inflammatory, cytotoxic, & anti- arthritic agents, to name a few.

   • According to DZIB-GUERRA WC (2016)

     Excerpt Objective: to test ethanolic extracts & aqueous-traditional preparations of plants used to treat diabetes, hypertension & obesity in Yucatecan traditional medicine for their anti-AGE & free radical scavenging activities. Formation & accumulation of advanced glycation end-products (AGE) is recognized as a major pathogenic process in diabetic complications, atherosclerosis & cardiovascular diseases.

3. 3

   Cancer: adjuvant treatment for breast cancer

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to SUMITHRA P (2014)

     Excerpt Hence the present study was directed to evaluate the anti-cancer activity of ethanolic extract of the flowers of Annona squamosa & Manilkara zapota against MCF-7 breast cancer cell lines in vitro & was compared with the normal, Vero cell lines. The study confirms the anti-cancer activity of both the plant extracts & hence can be used to develop them as a novel drug for the management of breast cancer.

   • According to Ma J (2003)

     Excerpt Activity-guided fractionation of a methanol extract from the fruit of Manilkara zapota cv. Of the 10 polyphenols, 1 showed the highest antioxidant activity (IC50 = 12.9 μM) in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay & displayed cytotoxicity in the HCT-116 & SW-480 human colon cancer cell lines with IC50 values of 190 & 160 μM, respectively.

   • According to Osman MA (2011)

     Excerpt To evaluate the antitumor activity of Manilkara zapota stem bark against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. After administration of the extract of MZ, viable EAC cell count & body weight in the EAC tumour hosts were observed.

   • According to Abu Osman (2011)

     Excerpt To evaluate the antitumor activity of Manilkara zapota (M. zapota, viable EAC cell count and body weight in the EAC tumour hosts were observed.

   • According to Rivas-Gastelum M.F (2023)

     Excerpt Manilkara zapota “chicozapote” is an autochthonous evergreen tree from the Southern regions of Mexico, Belize, & Guatemala. These beneficial properties assist in preventing chronic & degenerative diseases, such as cancer, diabetes, neurological, infectious, & cardiovascular diseases.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.