Manilkara zapota (Sapotiy) : vertus médicinales en extraction alcoolique

Manilkara zapota (Sapotiy, Sapotille) — famille Sapotacées.

Synonymes scientifiques : Achras zapota-L, Calocarpum mammosum-Pierre, Lucuma mammosa-CF Gaertn, Pouteria mammosa-Cronquist.

Sources externes reconnues associées à cette monographie : TRAMIL.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 12 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 35 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Douleur neuropathique du diabétique

   Partie usitée : écorce de Tige.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Karie PP (2022)

     Extrait A perusal of the literature suggested that Manilkara zapota stem bark (MZSB) is enriched with several bioactive phytoconstituents but had not been yet screened for its in vitro & in vivo antidiabetic potentials. Thus, the present study aimed to investigate the effects of 70% ethanolic extract of MZ stem bark (EMZSB) in DPPH- and H2O2-scavenging assay, in vitro α-glucosidase inhibition assay, ameliorating diabetes & its complications in alloxan-induced diabetes in Wistar rats.

   • Selon Karie PP (2022)

     Extrait However, for evaluating antidiabetic effects of fractions (chloroform, acetone, ethyl acetate, & remaining ethanol fraction) of EMZFP, diabetes was induced by streptozotocin (60 mg kg-1)-nicotinamide (120 mg kg-1/ml) in differently grouped male rats (n=6). Diabetic rats were treated with EMZFP fractions 200 mg kg-1 however; Glibenclamide (10 mg kg-1) was a reference standard & evaluated for blood glucose, serum lipids, cardiovascular risk indices, & diabetic neuropathy.

   • Selon Rivas-Gastelum M.F (2023)

     Extrait Manilkara zapota “chicozapote” is an autochthonous evergreen tree from the Southern regions of Mexico, Belize, & Guatemala. These bioactive compounds exert several biological activities, i.e., as an antioxidant, antidiabetic, antimicrobial, anti-inflammatory, cytotoxic, & anti- arthritic agents, to name a few.

   • Selon Barbalho SM (2015)

     Extrait zapota leaf juice or fruit juice, after which their biochemical & body composition profiles were analyzed (glycemia, triglycerides, high-density lipoprotein cholesterol (HDL-c), insulin, leptin, aspartate transaminase, alanine aminotransferase, Lee Index, & body mass index). Manilkara zapota is a tropical evergreen tree belonging to the Sapotaceae family; its parts are used in alternative medicine to treat coughs & colds & possess diuretic, antidiarrheal, antibiotic, antihyperglycemic, & hypocholesterolemic effects.

   • Selon DZIB-GUERRA WC (2016)

     Extrait Objective: to test ethanolic extracts & aqueous-traditional preparations of plants used to treat diabetes, hypertension & obesity in Yucatecan traditional medicine for their anti-AGE & free radical scavenging activities. Formation & accumulation of advanced glycation end-products (AGE) is recognized as a major pathogenic process in diabetic complications, atherosclerosis & cardiovascular diseases.

2. 2

   Diabète mellitus de type II

   Partie usitée : Fruit. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Karie PP (2022)

     Extrait However, for evaluating antidiabetic effects of fractions (chloroform, acetone, ethyl acetate, & remaining ethanol fraction) of EMZFP, diabetes was induced by streptozotocin (60 mg kg-1)-nicotinamide (120 mg kg-1/ml) in differently grouped male rats (n=6). Methods: Antidiabetic effects of EMZFP were assessed in alloxan (150 mg kg-1) induced diabetes in differently grouped rats (n=6).

   • Selon Karie PP (2022)

     Extrait A perusal of the literature suggested that Manilkara zapota stem bark (MZSB) is enriched with several bioactive phytoconstituents but had not been yet screened for its in vitro & in vivo antidiabetic potentials. Thus, the present study aimed to investigate the effects of 70% ethanolic extract of MZ stem bark (EMZSB) in DPPH- and H2O2-scavenging assay, in vitro α-glucosidase inhibition assay, ameliorating diabetes & its complications in alloxan-induced diabetes in Wistar rats.

   • Selon Barbalho SM (2015)

     Extrait zapota leaf juice or fruit juice, after which their biochemical & body composition profiles were analyzed (glycemia, triglycerides, high-density lipoprotein cholesterol (HDL-c), insulin, leptin, aspartate transaminase, alanine aminotransferase, Lee Index, & body mass index). Manilkara zapota is a tropical evergreen tree belonging to the Sapotaceae family; its parts are used in alternative medicine to treat coughs & colds & possess diuretic, antidiarrheal, antibiotic, antihyperglycemic, & hypocholesterolemic effects.

   • Selon Rivas-Gastelum M.F (2023)

     Extrait Manilkara zapota “chicozapote” is an autochthonous evergreen tree from the Southern regions of Mexico, Belize, & Guatemala. These bioactive compounds exert several biological activities, i.e., as an antioxidant, antidiabetic, antimicrobial, anti-inflammatory, cytotoxic, & anti- arthritic agents, to name a few.

   • Selon DZIB-GUERRA WC (2016)

     Extrait Objective: to test ethanolic extracts & aqueous-traditional preparations of plants used to treat diabetes, hypertension & obesity in Yucatecan traditional medicine for their anti-AGE & free radical scavenging activities. Formation & accumulation of advanced glycation end-products (AGE) is recognized as a major pathogenic process in diabetic complications, atherosclerosis & cardiovascular diseases.

3. 3

   Cancer : traitement adjuvant du carcinome mammaire

   Partie usitée : Fleur.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon SUMITHRA P (2014)

     Extrait Hence the present study was directed to evaluate the anti-cancer activity of ethanolic extract of the flowers of Annona squamosa & Manilkara zapota against MCF-7 breast cancer cell lines in vitro & was compared with the normal, Vero cell lines. The study confirms the anti-cancer activity of both the plant extracts & hence can be used to develop them as a novel drug for the management of breast cancer.

   • Selon Ma J (2003)

     Extrait Activity-guided fractionation of a methanol extract from the fruit of Manilkara zapota cv. Of the 10 polyphenols, 1 showed the highest antioxidant activity (IC50 = 12.9 μM) in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay & displayed cytotoxicity in the HCT-116 & SW-480 human colon cancer cell lines with IC50 values of 190 & 160 μM, respectively.

   • Selon Osman MA (2011)

     Extrait To evaluate the antitumor activity of Manilkara zapota stem bark against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. After administration of the extract of MZ, viable EAC cell count & body weight in the EAC tumour hosts were observed.

   • Selon Abu Osman (2011)

     Extrait To evaluate the antitumor activity of Manilkara zapota (M. zapota, viable EAC cell count and body weight in the EAC tumour hosts were observed.

   • Selon Rivas-Gastelum M.F (2023)

     Extrait Manilkara zapota “chicozapote” is an autochthonous evergreen tree from the Southern regions of Mexico, Belize, & Guatemala. These beneficial properties assist in preventing chronic & degenerative diseases, such as cancer, diabetes, neurological, infectious, & cardiovascular diseases.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.