Melia azedarach (Lila-péyi) : medicinal properties in alcoholic extraction

Melia azedarach (Lila-péyi, Local lilacs, Lilas du pays) — family Méliacées.

Scientific synonyms : Melia sempervirens-Sw.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 21 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 41 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Normalisation of blood test results: SGPT, SGOT, ALP, bilirubin

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ahmed MS (2013)

     Excerpt The present study deals with comparative evaluation of hepatoprotective activities of Melia azedarach Linn, Catharanthus Rosea & Brassica oleracea L.var.capitata ethanolic leaves extracts against simvastatin induced hepatotoxicity in rats. increases in Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alanine Phosphatase (ALP), Serum Bilirubin & decrease in Total proteins content, which were restored towards normalization in extracts treated rats.

   • According to Srinivasan Rao A (2012)

     Excerpt There was a significant change in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP), serum Bilirubin & decrease the total proteins content.) in simvastatin treated rats, which were restored towards normalization in M azedarach (300 mg/kg & 500 mg/kg) treated animals. The aim of the study is to investigate the hepatoprotective activity of Melia azedarach leaves extracts against simvastatin induced hepatotoxicity.

   • According to Samudram P (2008)

     Excerpt The substantially elevated serum marker enzymes such as Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Lactate dehydrogenase (LDH), Gamma glutamyl Transferase (γGT) & 5 Nucleotidase (5NT), due to CCl4 treatment were restored towards normalization in rats pretreated with BHEE. The determination of liver weight & biochemical parameters such as serum Bilirubin and blood urea showed a remarkable decrease in rats pre- treated with the BHEE when compared with those administered CCl4 alone.

   • According to Irshan Y (2017)

     Excerpt The objective of this research is to evaluate the potency of Melia azedarach leaves ethanolic extract as anticancer by inhibition of cancer cell proliferation. Cytotoxic effect was analyzed by Brine Shrimp Lethality Test (BSLT) and cell viability (MTT) methods using Chang human normal liver cells and A549 human lung cancer cells.

   • According to Kavitha M (2011)

     Excerpt Ethanolic extract from the leaves of Melia Azadirachta, seeds of Piper longum & whole plant of Eclipta alba at a dose level of 50 mg/kg body weight was administered orally daily once for 14 days. The Poly herbal ethanolic extract (PHEE) was evaluated for its anti-hepatotoxic potential against carbon tetrachloride (CCL 4) induced hepatic damage in male albino rats.

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Babu PS (2004)

     Excerpt Rats were rendered diabetic by streptozotocin (STZ) (45 mg kg (-1) body weight). Hyponidd is a herbomineral formulation composed of the extracts of ten medicinal plants (Momordica charantia, Melia Azadirachta, Pterocarpus marsupium, Tinospora cordifolia, Gymnema sylvestre, Eniscostema littorale, Emblica officinalis, Eugenia jambolana, Cassia auriculata & Curcuma longa).

   • According to Chinna-Samy G (2019)

     Excerpt Methods: Aqueous leaf extract from Melia azedarach (MA) was utilized for bio-synthesis of silver nanoparticles (MA-AgNPs). The MA-AgNPs (400 µg/mL) demonstrated high antidiabetic efficacy as measured by α-amylase (85.75%) & α-glucosidase (80.33%) inhibition assays & antioxidant activity as analyzed by DPPH (63.83%) & ABTS (63.61%) radical scavenging assays.

   • According to Roop JK (2005)

     Excerpt indica seed extract at 3 & 6 mg kg body weight-1 day-1 & Melia azedarach Linn. Juss (neem) is used in traditional medicine for its antidiabetic, spermicidal, antifertility, antibacterial, & wound healing properties.

3. 3

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Sheet. Mentioned synergistic association: Piper longum-semence, ECLIPTA ALBA-(L)-Hassk.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Samudram P (2008)

     Excerpt Ethanolic extract from the leaves of Melia azedarach & seeds of Piper longum at a dose level of 50 mg kg-1 body weight was administered orally daily once for 14 days, prior to the administration of 0.2 mL of CCl4 kg-1 body weight for 7 days. The combined hepatoprotective effect of Biherbal Ethanolic Extract (BHEE) pretreatment against carbon tétra chloride (CCl4) induced hepatic damage in rats was investigated.

   • According to Kavitha M (2011)

     Excerpt Ethanolic extract from the leaves of Melia Azadirachta, seeds of Piper longum & whole plant of Eclipta alba at a dose level of 50 mg/kg body weight was administered orally daily once for 14 days. The Poly herbal ethanolic extract (PHEE) was evaluated for its anti-hepatotoxic potential against carbon tetrachloride (CCL 4) induced hepatic damage in male albino rats.

   • According to Ahmed MS (2013)

     Excerpt The present study deals with comparative evaluation of hepatoprotective activities of Melia azedarach Linn, Catharanthus Rosea & Brassica oleracea L.var.capitata ethanolic leaves extracts against simvastatin induced hepatotoxicity in rats. The hepatoprotective effect of extracts was further confirmed by histopathological studies of liver, which shows normal architecture of liver cell than compared with hepatotoxicant group.

   • According to Irshan Y (2017)

     Excerpt The objective of this research is to evaluate the potency of Melia azedarach leaves ethanolic extract as anticancer by inhibition of cancer cell proliferation. Cytotoxic effect was analyzed by Brine Shrimp Lethality Test (BSLT) and cell viability (MTT) methods using Chang human normal liver cells and A549 human lung cancer cells.

   • According to Srinivasan Rao A (2012)

     Excerpt The aim of the study is to investigate the hepatoprotective activity of Melia azedarach leaves extracts against simvastatin induced hepatotoxicity. Leaves of M azedarach was successively extracted with ethanol against simvastatin (20mg/kg.p.o) induced hepatotoxicity using Standard drug Silymarin (25 mg/kg).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.