Melia azedarach (Lila-péyi) : vertus médicinales en extraction alcoolique

Melia azedarach (Lila-péyi, Lilas du pays, Local lilacs) — famille Méliacées.

Synonymes scientifiques : Melia sempervirens-Sw.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 21 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 41 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Normalisation des paramètres biologiques sanguins : SGPT, SGOT, ALP, Bilirubine

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Ahmed MS (2013)

     Extrait The present study deals with comparative evaluation of hepatoprotective activities of Melia azedarach Linn, Catharanthus Rosea & Brassica oleracea L.var.capitata ethanolic leaves extracts against simvastatin induced hepatotoxicity in rats. increases in Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alanine Phosphatase (ALP), Serum Bilirubin & decrease in Total proteins content, which were restored towards normalization in extracts treated rats.

   • Selon Srinivasan Rao A (2012)

     Extrait There was a significant change in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP), serum Bilirubin & decrease the total proteins content.) in simvastatin treated rats, which were restored towards normalization in M azedarach (300 mg/kg & 500 mg/kg) treated animals. The aim of the study is to investigate the hepatoprotective activity of Melia azedarach leaves extracts against simvastatin induced hepatotoxicity.

   • Selon Samudram P (2008)

     Extrait The substantially elevated serum marker enzymes such as Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Lactate dehydrogenase (LDH), Gamma glutamyl Transferase (γGT) & 5 Nucleotidase (5NT), due to CCl4 treatment were restored towards normalization in rats pretreated with BHEE. The determination of liver weight & biochemical parameters such as serum Bilirubin and blood urea showed a remarkable decrease in rats pre- treated with the BHEE when compared with those administered CCl4 alone.

   • Selon Irshan Y (2017)

     Extrait The objective of this research is to evaluate the potency of Melia azedarach leaves ethanolic extract as anticancer by inhibition of cancer cell proliferation. Cytotoxic effect was analyzed by Brine Shrimp Lethality Test (BSLT) and cell viability (MTT) methods using Chang human normal liver cells and A549 human lung cancer cells.

   • Selon Kavitha M (2011)

     Extrait Ethanolic extract from the leaves of Melia Azadirachta, seeds of Piper longum & whole plant of Eclipta alba at a dose level of 50 mg/kg body weight was administered orally daily once for 14 days. The Poly herbal ethanolic extract (PHEE) was evaluated for its anti-hepatotoxic potential against carbon tetrachloride (CCL 4) induced hepatic damage in male albino rats.

2. 2

   Diabète mellitus de type II

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Babu PS (2004)

     Extrait Rats were rendered diabetic by streptozotocin (STZ) (45 mg kg (-1) body weight). Hyponidd is a herbomineral formulation composed of the extracts of ten medicinal plants (Momordica charantia, Melia Azadirachta, Pterocarpus marsupium, Tinospora cordifolia, Gymnema sylvestre, Eniscostema littorale, Emblica officinalis, Eugenia jambolana, Cassia auriculata & Curcuma longa).

   • Selon Chinna-Samy G (2019)

     Extrait Methods: Aqueous leaf extract from Melia azedarach (MA) was utilized for bio-synthesis of silver nanoparticles (MA-AgNPs). The MA-AgNPs (400 µg/mL) demonstrated high antidiabetic efficacy as measured by α-amylase (85.75%) & α-glucosidase (80.33%) inhibition assays & antioxidant activity as analyzed by DPPH (63.83%) & ABTS (63.61%) radical scavenging assays.

   • Selon Roop JK (2005)

     Extrait indica seed extract at 3 & 6 mg kg body weight-1 day-1 & Melia azedarach Linn. Juss (neem) is used in traditional medicine for its antidiabetic, spermicidal, antifertility, antibacterial, & wound healing properties.

3. 3

   Hépatite, cirrhose, stéatose hépatique

   Partie usitée : Feuille. Association synergique mentionnée : Piper longum-semence, ECLIPTA ALBA-(L)-Hassk.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Samudram P (2008)

     Extrait Ethanolic extract from the leaves of Melia azedarach & seeds of Piper longum at a dose level of 50 mg kg-1 body weight was administered orally daily once for 14 days, prior to the administration of 0.2 mL of CCl4 kg-1 body weight for 7 days. The combined hepatoprotective effect of Biherbal Ethanolic Extract (BHEE) pretreatment against carbon tétra chloride (CCl4) induced hepatic damage in rats was investigated.

   • Selon Kavitha M (2011)

     Extrait Ethanolic extract from the leaves of Melia Azadirachta, seeds of Piper longum & whole plant of Eclipta alba at a dose level of 50 mg/kg body weight was administered orally daily once for 14 days. The Poly herbal ethanolic extract (PHEE) was evaluated for its anti-hepatotoxic potential against carbon tetrachloride (CCL 4) induced hepatic damage in male albino rats.

   • Selon Ahmed MS (2013)

     Extrait The present study deals with comparative evaluation of hepatoprotective activities of Melia azedarach Linn, Catharanthus Rosea & Brassica oleracea L.var.capitata ethanolic leaves extracts against simvastatin induced hepatotoxicity in rats. The hepatoprotective effect of extracts was further confirmed by histopathological studies of liver, which shows normal architecture of liver cell than compared with hepatotoxicant group.

   • Selon Irshan Y (2017)

     Extrait The objective of this research is to evaluate the potency of Melia azedarach leaves ethanolic extract as anticancer by inhibition of cancer cell proliferation. Cytotoxic effect was analyzed by Brine Shrimp Lethality Test (BSLT) and cell viability (MTT) methods using Chang human normal liver cells and A549 human lung cancer cells.

   • Selon Srinivasan Rao A (2012)

     Extrait The aim of the study is to investigate the hepatoprotective activity of Melia azedarach leaves extracts against simvastatin induced hepatotoxicity. Leaves of M azedarach was successively extracted with ethanol against simvastatin (20mg/kg.p.o) induced hepatotoxicity using Standard drug Silymarin (25 mg/kg).

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.