Mirabilis jalapa (Bêl-di-nui) : medicinal properties in alcoholic extraction

Mirabilis jalapa (Bêl-di-nui, Night-beauty, Belle-de-nuit) — family Nyctaginacées.

Scientific synonyms : Mirabilis ambigua-T, M J, var Lindl-(S)-Cory, M Linderheimiri-(S)-Shin, Nyctago jalapae-(L)-DC.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 103 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sarkar P (2011)

     Excerpt This study was designed to investigate the Anti-diabetic activity of an ethanolic extract of the root of Mirabilis Jalapa which is widely being used in Himalayan region as a traditional treatment for diabetic mellitus. Ethanolic extract of Mirabilis Jalapa (EEMJ) (10mg/kg & 20mg/kg) were administered as a single dose per day to the streptozotocin-induced diabetic rats for 12 days.

   • According to Jiang Ming-Jin (n.d.)

     Excerpt Rats were divided into following groups: normal group,model group, ethanolic extract of MJ roots group(1,2,4 g · kg-1) & rosiglitazone group(4 mg · kg-1).After 8-weeks treatment,fasting blood glucose( FBG), hemoglobin(HbAlC), total cholesterol(TC), triglyceride(TG), serum insulin(FINS) levels & glycogen contents in liver & skeletal muscle were assayed. To investigate the effects of ethanolic extract of Mirabilis jalapa roots on glucolipid metabolization in diabetic rats.

   • According to Zhou JY (2012)

     Excerpt The present study investigated the insulin sensitivity, hypoglycemic, & hypolipidemic activities of ethanolic extract of Mirabilis jalapa L. Both after & before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level & improved insulin sensitivity index, & lowered serum total cholesterol, triglyceride levels & triglyceride content in liver & skeletal muscle, & increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice.

   • According to Luo LS (n.d.)

     Excerpt To study the effect of the extract of Mirabilis jalapa root on the blood glucose of normal mice & diabetes mice induced by adrenaline & glucose. Methods:High blood glucose model mice were made by 160μg/kg adrenaline solution & 10% glucose solution.The hypoglycemic effect of the extract of MJ root on the blood glucose of the model mice was observed.Results:The low,middle & high dose of the extract of MJ root had no effect on the normal mice (P0.05), but the high dose of the extract could lower the blood glucose levels of the adrenalin & high blood glucose mice( P0.05).

   • According to Rout S (2012)

     Excerpt Results: The fasting blood glucose level in normoglycemic, hyperglycemic and in oral glucose tolerance test, showed a significant (p<0.05) decrease at defined time points, while the observed biochemical & physical parameters showed a good agreement with antihyperglycemic property of the extract. Antidiabetic potential was assessed by the measurement of fasting blood glucose, Serum Lipid Profile (total cholesterol, triglycerides), physical parameters (body weight, food & water intake) & Oral Glucose tolerance test.

2. 2

   Liver disorders: hepatitis, cirrhosis, fatty liver, normalisation of serum parameters, liver disorders associated with the use of anti-tuberculosis medication

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Basini J (2013)

     Excerpt The present study was undertaken for investigating the protective effect of ethanolic extract of Mirabilis Jalapa leaves on anti-tubercular drugs induced hepatotoxicity. Conclusion: The result of the present study was indicated that MJ showed hepatoprotective effect on hepatotoxicity induced by anti-tubercular drugs.

   • According to Ahmad MS (1984)

     Excerpt A fatty acid, found as a minor component in the seed oil of Mirabilis jalapa, is shown to be the hitherto unknown 8-hydroxyoctadeca-cis-11,14-dienoic acid.

   • According to Zhou JY (2012)

     Excerpt The present study investigated the insulin sensitivity, hypoglycemic, & hypolipidemic activities of ethanolic extract of Mirabilis jalapa L. Both after & before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level & improved insulin sensitivity index, & lowered serum total cholesterol, triglyceride levels & triglyceride content in liver & skeletal muscle, & increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice.

   • According to Jiang Ming-Jin (n.d.)

     Excerpt Rats were divided into following groups: normal group,model group, ethanolic extract of MJ roots group(1,2,4 g · kg-1) & rosiglitazone group(4 mg · kg-1).After 8-weeks treatment,fasting blood glucose( FBG), hemoglobin(HbAlC), total cholesterol(TC), triglyceride(TG), serum insulin(FINS) levels & glycogen contents in liver & skeletal muscle were assayed. To investigate the effects of ethanolic extract of Mirabilis jalapa roots on glucolipid metabolization in diabetic rats.

   • According to Rout S (2012)

     Excerpt Antidiabetic potential was assessed by the measurement of fasting blood glucose, Serum Lipid Profile (total cholesterol, triglycerides), physical parameters (body weight, food & water intake) & Oral Glucose tolerance test. To evaluate the antihyperglycemic activity of hydro-alcoholic extract of aerial parts of Mirabilis jalapa for its purported use in diabetes.

3. 3

   Bacterial infection: Vibrio cholerae, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi and Serratia marcescens

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sankar NS (2015)

     Excerpt against seven pathogenic bacteria such as Vibrio cholerae, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi & Serratia maecescence, Among the water, methanol & ethanol extract, the ethanolic extract showed maximum activity. Antibacterial activity & phytochemical analysis were carried out in Mirabilis jalapa L.

   • According to MUHSINA CP (2017)

     Excerpt Antimicrobial activity of Mirabilis Jalapa leaf extracts were determined against the pathogens such as Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Candida albicans. Among all the solvents of Mirabilis Jalapa, the ethanolic leaf extract showed excellent activity against Staphylococcus aureus (36mm) and moderately against Candida albicans (29mm).

   • According to Salman SM (2015)

     Excerpt The antimicrobial activities of ethanolic extract of MJ were investigated against four strains of bacteria, Salmonella typhi, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa. The plants extract show high sensitivity against Pseudomonas aeruginosa & least sensitivity against Staphylococcus aureus.

   • According to Ali Saukat (2015)

     Excerpt The antimicrobial activities of ethanolic extract of MJ were investigated against four strains of bacteria, Salmonella typhi, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa. The main aims of this study was to identify all the bio active compounds present in the Mirabilis jalapa plant (leaves & stem) qualitatively by using four different solvent system (water, hexane, ethanol, & ethyl acetate).

   • According to Oladunmoye KM (2007)

     Excerpt The ethanolic extract of the leaf of Mirabilis jalapa was tested for antimicrobial activity against five pathogenic bacterial strains: Escherichia coli, Staphylococcus aureus, Salmonella typhi, Bacillus cereus & Klebsiella pneumoniae. The isolates producing the toxins were identified as Pseudomonas sp., Acinetobacter sp., Corynebacterium sp.,Actinomyces sp., Clostridium sp., Bacillus sp., Shigella sp., Proteus sp.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.