Momordica charantia (Pawoka) : medicinal properties in alcoholic extraction

Momordica charantia (Pawoka) — family Cucurbitacées.

Scientific synonyms : Cucumis argyi-H. Lèv, Momordica chinensis-Spreng, M sinensis-Spreng, Sycos fauriel-H. Lèv.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 34 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 262 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cataract associated with type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Srivastava S (1988)

     Excerpt was studied in Charles Foster rats of both sexes in respect of its dose-response hypoglycemia and at maximal effective dose, its influence on the development of diabetic cataract. Alloxan (120 mg/kg s.c./rat, single dose) diabetic rats with 7150 mg% of blood sugar were classified into four groups (n=10) wherein two were control and the rest were test groups).

   • According to Wardani BPN (2021)

     Excerpt Hyperglycemia is a condition of excessive blood glucose in blood plasma caused by damage to the pancreatic beta-cell structure that causes impaired insulin secretion. The conclusion of this study was MC & AB ethanol extract with a treatment of 40 mg.kg-1 BW can suppress IL-1b pro-inflammatory cytokines in hyperglycemic mice models, but has not been able to reduce the expression of IL-6 pro-inflammatory cytokines.

   • According to Yakaiah V (2013)

     Excerpt to investigate the anti-diabetic effect of the bitter melon on Alloxan induced diabetes in experimental animals (rabbits. Materials & Methods: the alcohol extract of whole fruit was tested for its efficacy in Alloxan (150mg/kg induced diabetic rabbit.

   • According to BISWAS AR (1991)

     Excerpt In the Ayurvedic system of medicine, the fruits of this plant have been traditionally used for the treatment of diabetes mellitus and hepatic disorders & for pain relief in gout & rheumatism (Satapathy et al., 19871.In the present study, an attempt has been made to evaluate the analgesic activity of this plant in animals. charantia (authenticated by the Department of Botany of our Institute), collected during the month of December, were shade dried at room temperature for four weeks before the seeds were separated out.

   • According to Hussain TS (2014)

     Excerpt To investigate hypoglycaemic, hypolipidaemic & pancreatic beta cell regeneration activities of Momordica charantia fruits. Alloxan-induced diabetic rabbits were treated with methanolic & ethanolic MC extract.

2. 2

   Adjuvant treatment for diabetic foot

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rosyid FN (2018)

     Excerpt Diabetic foot ulcer (DFU) is among the many complications of diabetes & it takes a very long period of time to heal. The aim & objective of this study is to assess the effect of bitter melon leaves extracts on serum TNF-α levels & improvement of diabetic foot ulcers.

   • According to KIM SK (2020)

     Excerpt charantia as an adjuvant treatment in patients with type 2 diabetes. Momordica charantia (bitter melon) is widely used for its glucose-lowering effects.

   • According to Offor U (2018)

     Excerpt In conclusion MC extract administration improved blood glucose levels, restored renal histology, reinstate renal function, reduce body weight loss & restores hyperglycemia. charantia in rats following treatment with highly active antiretroviral therapy (HAART) regimen triplavar.

   • According to Srivastava S (1988)

     Excerpt Alloxan (120 mg/kg s.c./rat, single dose) diabetic rats with 7150 mg% of blood sugar were classified into four groups (n=10) wherein two were control and the rest were test groups). was studied in Charles Foster rats of both sexes in respect of its dose-response hypoglycemia and at maximal effective dose, its influence on the development of diabetic cataract.

   • According to Malik ZA (2013)

     Excerpt Malik ZA et al, Attenuation of experimentally induced diabetic neuropathy in association with reduced oxidative-nitrosative stress by chronic administration of < i> Momordica charantia & lt;/i&gt, Adv in Bioscience & Biotechnol, 04: 356-63, 2013,.

3. 3

   Type II diabetes mellitus (Acarbose/Glibenclamide-like only in synergistic combination)

   Plant part used: Fruit. Mentioned synergistic association: Momordica dioica-fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Wardani BPN (2021)

     Excerpt This study aimed to investigate the combination of Bitter Melon & Star Fruit ethanol extract (SBME) on pro-inflammatory cytokines production in hyperglycemic albino mice models. Hyperglycemia is a condition of excessive blood glucose in blood plasma caused by damage to the pancreatic beta-cell structure that causes impaired insulin secretion.

   • According to Savula J (2012)

     Excerpt Momordica charantia is commonly known as bitter melon & Momordica dioica commonly known as bitter melon both are very commonly available plants of Andra-Pradesh both fruits are proved to have antidiabetic activity. Ethanolic & Aqueous extracts of both Momordica fruits were prepared by Maceration, Percolation & Soxhlation & subjected to phytochemical screening & tested for anti-diabetic activity in alloxan induced diabetic rats.

   • According to Yadav U (2005)

     Excerpt The present study was undertaken to investigate the effects of treatment of Momordica charantia fruit extract & sodium orthovanadate, separately and in combination, on serum and tissue lipid profile & on the activities of lipogenic enzymes in alloxan induced diabetic rats. Momordica charantia commonly called bitter gourd, is a medicinal plant used in the Ayurvedic system of medicine for treating various diseases including diabetes mellitus.

   • According to Yakaiah V (2013)

     Excerpt to investigate the anti-diabetic effect of the bitter melon on Alloxan induced diabetes in experimental animals (rabbits. Materials & Methods: the alcohol extract of whole fruit was tested for its efficacy in Alloxan (150mg/kg induced diabetic rabbit.

   • According to BISWAS AR (1991)

     Excerpt In the Ayurvedic system of medicine, the fruits of this plant have been traditionally used for the treatment of diabetes mellitus and hepatic disorders & for pain relief in gout & rheumatism (Satapathy et al., 19871.In the present study, an attempt has been made to evaluate the analgesic activity of this plant in animals. Pilot studies with the various extracts revealed that only the methanol extract (yield 9.4 g/100 g of dry seeds) exhibited a significant analgesic response.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.