Momordica dioica (Qwo Pawoka) : medicinal properties in alcoholic extraction

Momordica dioica (Qwo Pawoka, Bitter gourd, Large bitter gourd, Small bitter gourd, Ti konkonb anmè, Gros paroka, Petit concombre amer) — family Cucurbitacées.

Scientific synonyms : Bryonia grandis Wall., Momordica hamiltoniana Wall., M hamiltoniana Wall. ex G.Don, M heyneana Wall., M heyneana Wall. ex G.Don, M hispida Dennst., M hispida Dennst. ex Miq., M missionis Wall., M roxburghii G.Don, M sicyoides Ser., M triloba Wight, M trilobata Wight, M trilobata Wight ex Steud., M tuberosa Dennst., M tuberosa Dennst. ex Miq., M wallichii M.Roem., M wallichii Roem. Trichosanthes russeliana Wall., T russeliana Wall. ex G.Don.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 51 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Liver disorders: cirrhosis, hepatitis, fatty liver, abnormal serum levels: ALP, ALT, AST, SGPT, SGOT, total bilirubin

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ilango K (2004)

     Excerpt The extracts, at a dose of 400 mg/kg (po) administered for 7 days exhibited a significant therapeutic effect by lowering Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), serum alkaline phosphatase (ALP) & serum bilirubin & increasing the serum levels. Abstract the Hexane Extract (HE) & Ethyl Acetate Soluble Fraction of the Methanolic Extract (EASFME) of the fruit pulp of Momordica dioica Roxb.

   • According to Kushwaha SK (2005)

     Excerpt The flavonoidal fraction collected from column chromatography from ethanolic extract of fruits of Momordica dioica Roxb was evaluated for hepatoprotective activity in Wistar strain of albino rats of either sex against carbon tetrachloride induced hepatic damage. The fraction caused decrease in serum level of enzymes serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphate & total bilirubin in treated rats as compared to control.

   • According to Shreedhara CS (2006)

     Excerpt The alcoholic extract of Momordica dioica roots significantly reduced $CCl_4$ induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxalo-acetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), & alkaline phosphatase (ALP)].

   • According to Hassan M (2022)

     Excerpt Water, Glibenclamide & MD extracts were fed to Streptozocin induced type-2 diabetic rat models at a dose of 1.25g/kg body weight (bw) for 28 days to see what kind of effects they had on serum glucose, insulin, liver glycogen & lipid contents. The treatment of diabetic model rats with extract resulted in a 7% (p < 0.0001) reduction in serum cholesterol levels.

   • According to Mynul Hassan (2022)

     Excerpt Water, Glibenclamide & MD extracts were fed to Streptozocin induced type-2 diabetic rat models at a dose of 1.25 g/kg body weight (bw) for 28 days to see what kind of effects they had on serum glucose, insulin, liver glycogen & lipid contents. Momordica dioica is a gourd like blooming plant that is readily available in Bangladesh, requiring biological research to discover its therapeutic values.

2. 2

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Singh R (2011)

     Excerpt the aim of the study was to evaluate the antidiabetic effect of Momordica dioica fruit extracts in alloxan induced diabetic Wistar rats. Since AEMD exhibited maximum hypoglycaemic activity as compared to other extracts, it was further studied for antidiabetic effect in diabetic rats.

   • According to Hassan M (2022)

     Excerpt Water, Glibenclamide & MD extracts were fed to Streptozocin induced type-2 diabetic rat models at a dose of 1.25g/kg body weight (bw) for 28 days to see what kind of effects they had on serum glucose, insulin, liver glycogen & lipid contents. Momordica dioica (M.

   • According to Savula J (2012)

     Excerpt Ethanolic & Aqueous extracts of both Momordica fruits were prepared by Maceration, Percolation & Soxhlation & subjected to phytochemical screening & tested for anti-diabetic activity in alloxan induced diabetic rats. Momordica charantia is commonly known as bitter melon & Momordica dioica commonly known as bitter melon both are very commonly available plants of Andra-Pradesh both fruits are proved to have antidiabetic activity.

   • According to Mynul Hassan (2022)

     Excerpt Water, Glibenclamide & MD extracts were fed to Streptozocin induced type-2 diabetic rat models at a dose of 1.25 g/kg body weight (bw) for 28 days to see what kind of effects they had on serum glucose, insulin, liver glycogen & lipid contents. Momordica dioica is a gourd like blooming plant that is readily available in Bangladesh, requiring biological research to discover its therapeutic values.

   • According to Nandini HS (2020)

     Excerpt The hypoglycaemic group three doses of 100,200 & 400 mg/kg of each extract & Vit-E (10mg/kg) was used as standard along with the glibenclamide (1.5mg/kg) as a standard antidiabetic drug & treated with the extracts for 15days. The present study has explored the cardioprotective effects of extracts of fruits of Momordica dioica Roxb in rats.

3. 3

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shreedhara CS (2006)

     Excerpt The alcoholic extract of Momordica dioica roots significantly reduced $CCl_4$ induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxalo-acetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), & alkaline phosphatase (ALP)]. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) & the activity was comparable with ibuprofen (200 mg/kg, p.o.).

   • According to Sundur S (2014)

     Excerpt Studies indicate that it possesses antioxidant, hepatoprotective, antibacterial, anti-inflammatory, anti-lipid peroxidative, hypoglycemic & analgesic properties. Momordica dioica is traditionally used as astringent, febrifuge, antiseptic, anthelmintic, spermicidal.

   • According to Ilango K (2003)

     Excerpt Ilango K et al, Analgesic & Anti‐ inflammatory activity of Momordica dioica fruits pulp.

   • According to Ilango K (2004)

     Excerpt Abstract the Hexane Extract (HE) & Ethyl Acetate Soluble Fraction of the Methanolic Extract (EASFME) of the fruit pulp of Momordica dioica Roxb. (Cucurbitaceae) was evaluated for its anti-hepatotoxic activity in rats.

   • According to Rakh MS (2012)

     Excerpt dioica) Methods: Petroleum ether, ethyl acetate, methanol & aqueous extracts of MD seed were screened for anti-allergic activity (200 mg/kg (i.p.) in mice body wt.) & analgesic (dose dependant 50 mg/kg & 100 mg/kg in mice body wt.). To evaluate the antiallergic & analgesic activities of seed of Momordica dioica Roxb.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.