Momordica dioica (Qwo Pawoka) : vertus médicinales en extraction alcoolique

Momordica dioica (Qwo Pawoka, Ti konkonb anmè, Gros paroka, Petit concombre amer, Bitter gourd, Large bitter gourd, Small bitter gourd) — famille Cucurbitacées.

Synonymes scientifiques : Bryonia grandis Wall., Momordica hamiltoniana Wall., M hamiltoniana Wall. ex G.Don, M heyneana Wall., M heyneana Wall. ex G.Don, M hispida Dennst., M hispida Dennst. ex Miq., M missionis Wall., M roxburghii G.Don, M sicyoides Ser., M triloba Wight, M trilobata Wight, M trilobata Wight ex Steud., M tuberosa Dennst., M tuberosa Dennst. ex Miq., M wallichii M.Roem., M wallichii Roem. Trichosanthes russeliana Wall., T russeliana Wall. ex G.Don.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 13 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 51 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Troubles hépatiques : cirrhose, hépatite, stéatose hépatique, anormalité des paramètres sériques : ALP, ALT, AST, SGPT, SGOT, Bilirubine totale

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Ilango K (2004)

     Extrait The extracts, at a dose of 400 mg/kg (po) administered for 7 days exhibited a significant therapeutic effect by lowering Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), serum alkaline phosphatase (ALP) & serum bilirubin & increasing the serum levels. Abstract the Hexane Extract (HE) & Ethyl Acetate Soluble Fraction of the Methanolic Extract (EASFME) of the fruit pulp of Momordica dioica Roxb.

   • Selon Kushwaha SK (2005)

     Extrait The flavonoidal fraction collected from column chromatography from ethanolic extract of fruits of Momordica dioica Roxb was evaluated for hepatoprotective activity in Wistar strain of albino rats of either sex against carbon tetrachloride induced hepatic damage. The fraction caused decrease in serum level of enzymes serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphate & total bilirubin in treated rats as compared to control.

   • Selon Shreedhara CS (2006)

     Extrait The alcoholic extract of Momordica dioica roots significantly reduced $CCl_4$ induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxalo-acetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), & alkaline phosphatase (ALP)].

   • Selon Hassan M (2022)

     Extrait Water, Glibenclamide & MD extracts were fed to Streptozocin induced type-2 diabetic rat models at a dose of 1.25g/kg body weight (bw) for 28 days to see what kind of effects they had on serum glucose, insulin, liver glycogen & lipid contents. The treatment of diabetic model rats with extract resulted in a 7% (p < 0.0001) reduction in serum cholesterol levels.

   • Selon Mynul Hassan (2022)

     Extrait Water, Glibenclamide & MD extracts were fed to Streptozocin induced type-2 diabetic rat models at a dose of 1.25 g/kg body weight (bw) for 28 days to see what kind of effects they had on serum glucose, insulin, liver glycogen & lipid contents. Momordica dioica is a gourd like blooming plant that is readily available in Bangladesh, requiring biological research to discover its therapeutic values.

2. 2

   Diabète mellitus de type II

   Partie usitée : Fruit. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Singh R (2011)

     Extrait the aim of the study was to evaluate the antidiabetic effect of Momordica dioica fruit extracts in alloxan induced diabetic Wistar rats. Since AEMD exhibited maximum hypoglycaemic activity as compared to other extracts, it was further studied for antidiabetic effect in diabetic rats.

   • Selon Hassan M (2022)

     Extrait Water, Glibenclamide & MD extracts were fed to Streptozocin induced type-2 diabetic rat models at a dose of 1.25g/kg body weight (bw) for 28 days to see what kind of effects they had on serum glucose, insulin, liver glycogen & lipid contents. Momordica dioica (M.

   • Selon Savula J (2012)

     Extrait Ethanolic & Aqueous extracts of both Momordica fruits were prepared by Maceration, Percolation & Soxhlation & subjected to phytochemical screening & tested for anti-diabetic activity in alloxan induced diabetic rats. Momordica charantia is commonly known as bitter melon & Momordica dioica commonly known as bitter melon both are very commonly available plants of Andra-Pradesh both fruits are proved to have antidiabetic activity.

   • Selon Mynul Hassan (2022)

     Extrait Water, Glibenclamide & MD extracts were fed to Streptozocin induced type-2 diabetic rat models at a dose of 1.25 g/kg body weight (bw) for 28 days to see what kind of effects they had on serum glucose, insulin, liver glycogen & lipid contents. Momordica dioica is a gourd like blooming plant that is readily available in Bangladesh, requiring biological research to discover its therapeutic values.

   • Selon Nandini HS (2020)

     Extrait The hypoglycaemic group three doses of 100,200 & 400 mg/kg of each extract & Vit-E (10mg/kg) was used as standard along with the glibenclamide (1.5mg/kg) as a standard antidiabetic drug & treated with the extracts for 15days. The present study has explored the cardioprotective effects of extracts of fruits of Momordica dioica Roxb in rats.

3. 3

   Arthrose, arthrite, rhumatisme, oedème

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Shreedhara CS (2006)

     Extrait The alcoholic extract of Momordica dioica roots significantly reduced $CCl_4$ induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxalo-acetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), & alkaline phosphatase (ALP)]. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) & the activity was comparable with ibuprofen (200 mg/kg, p.o.).

   • Selon Sundur S (2014)

     Extrait Studies indicate that it possesses antioxidant, hepatoprotective, antibacterial, anti-inflammatory, anti-lipid peroxidative, hypoglycemic & analgesic properties. Momordica dioica is traditionally used as astringent, febrifuge, antiseptic, anthelmintic, spermicidal.

   • Selon Ilango K (2003)

     Extrait Ilango K et al, Analgesic & Anti‐ inflammatory activity of Momordica dioica fruits pulp.

   • Selon Ilango K (2004)

     Extrait Abstract the Hexane Extract (HE) & Ethyl Acetate Soluble Fraction of the Methanolic Extract (EASFME) of the fruit pulp of Momordica dioica Roxb. (Cucurbitaceae) was evaluated for its anti-hepatotoxic activity in rats.

   • Selon Rakh MS (2012)

     Extrait dioica) Methods: Petroleum ether, ethyl acetate, methanol & aqueous extracts of MD seed were screened for anti-allergic activity (200 mg/kg (i.p.) in mice body wt.) & analgesic (dose dependant 50 mg/kg & 100 mg/kg in mice body wt.). To evaluate the antiallergic & analgesic activities of seed of Momordica dioica Roxb.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.