Morus nigra (Mulberry tree) : medicinal properties in alcoholic extraction

Morus nigra (Mulberry tree, Murier) — family Moracées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 37 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hago Salma A. (2013)

     Excerpt The results suggest that BMFE can be used as a safe nutraceutical agent to ameliorate hyperglycemia associated with type II diabetes & it might also be useful in preventing secondary diabetic complications.

   • According to Vukmirovic S (2023)

     Excerpt The framework of this study was a comprehensive investigation of Morus nigra extracts, with the aim to establish the correlation between chemical composition & antioxidant/ hepatoprotective activity of a series of MN extracts obtained from aerial parts of the plant MN leaf (MLEE), bark (MBEE), juice (MJ) & fresh fruit (MFEE) extracts were obtained using the conventional Soxhlet extraction, while the supercritical CO2 extraction procedure was employed for preparation of the seed oil (MSO). In Haan strain NMRI mice with streptozotocin-induced oxidative stress, in vivo antioxidant activity and liver tissue integrity were examined.

   • According to Da Silva A JRG (2012)

     Excerpt Da Silva A JRG et al, Medicinal plants & natural compounds from the genus Morus (Moraceae) with Hypoglycemic activity: A review, Intechopen 2012.

   • According to ENRUYGUR N (2019)

     Excerpt Morus alba & Morus nigra leaves which have been widely used as herbal teas in Anatolian region of Turkey, were extracted twice by 50 mM HCI solution, derivatized with 9-fluorenylmethyl chloroformate & analyzed by reversed phase HPLC equipped with a fluorescence detector. Hypothesis/ purpose: This study was performed to determine the main antidiabetic active compounds 1-deoxyno-jirimycin by HPLC method & evaluate the in-vitro antioxidant & antidiabetic activity of ethanol extracts prepared from MA & MN leaves.

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hago Salma A. (2013)

     Excerpt The results suggest that BMFE can be used as a safe nutraceutical agent to ameliorate hyperglycemia associated with type II diabetes & it might also be useful in preventing secondary diabetic complications.

   • According to Vukmirovic S (2023)

     Excerpt The framework of this study was a comprehensive investigation of Morus nigra extracts, with the aim to establish the correlation between chemical composition & antioxidant/ hepatoprotective activity of a series of MN extracts obtained from aerial parts of the plant MN leaf (MLEE), bark (MBEE), juice (MJ) & fresh fruit (MFEE) extracts were obtained using the conventional Soxhlet extraction, while the supercritical CO2 extraction procedure was employed for preparation of the seed oil (MSO). In Haan strain NMRI mice with streptozotocin-induced oxidative stress, in vivo antioxidant activity and liver tissue integrity were examined.

   • According to Da Silva A JRG (2012)

     Excerpt Da Silva A JRG et al, Medicinal plants & natural compounds from the genus Morus (Moraceae) with Hypoglycemic activity: A review, Intechopen 2012.

   • According to ENRUYGUR N (2019)

     Excerpt Morus alba & Morus nigra leaves which have been widely used as herbal teas in Anatolian region of Turkey, were extracted twice by 50 mM HCI solution, derivatized with 9-fluorenylmethyl chloroformate & analyzed by reversed phase HPLC equipped with a fluorescence detector. Hypothesis/ purpose: This study was performed to determine the main antidiabetic active compounds 1-deoxyno-jirimycin by HPLC method & evaluate the in-vitro antioxidant & antidiabetic activity of ethanol extracts prepared from MA & MN leaves.

3. 3

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hago Salma A. (2013)

     Excerpt Furthermore, administration of BMFE at two different doses significantly improved liver and kidney function in diabetic rats.

   • According to Author (2015)

     Excerpt The possible hepatoprotective effect of the administration of Mulberry ethanolic extract (MUL) leaves against Hepatotoxic effect of the antirheumatic drug, methotrexate (MTX) was evaluated in this study both vivo (using animal models) and in vitro (human hepatoma HepG2 cells).METHODS: In the in-vivo study, 20 male albino rats were equally assigned into four groups; control group received distilled water orally; MUL treated-group received 500 mg/kg/day of MUL extract; MTX treated-group was injected with a single dose of 20 mg/kg MTX intraperitoneally on the 4th day; MUL-MTX treated-group received the previously mentioned doses of MUL & MTX (both control & MUL treated groups were administered a single dose of a physiological saline i.p.). At the end of the experimental period (14 days) activities of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) & lactate dehydrogenase (LDH) as well as total serum protein (TP) & albumin (ALB) levels were evaluated to assess liver function.

   • According to Gonzalez-Condori EG (2021)

     Excerpt Objective: Evaluate the hepatoprotective effect of Morus nigra hydroalcoholic extract on acetaminophen-induced liver damage in rats. Methods: Twenty rats (Rattus novergicus albinus) were distributed into four groups: control, acetaminophen (250 mg/kg) as hepatotoxicity control group, acetaminophen + silymarin (100 mg/kg) and acetaminophen + Morus nigra L.

   • According to Vukmirovic S (2023)

     Excerpt The framework of this study was a comprehensive investigation of Morus nigra extracts, with the aim to establish the correlation between chemical composition & antioxidant/ hepatoprotective activity of a series of MN extracts obtained from aerial parts of the plant MN leaf (MLEE), bark (MBEE), juice (MJ) & fresh fruit (MFEE) extracts were obtained using the conventional Soxhlet extraction, while the supercritical CO2 extraction procedure was employed for preparation of the seed oil (MSO). In Haan strain NMRI mice with streptozotocin-induced oxidative stress, in vivo antioxidant activity and liver tissue integrity were examined.

   • According to Mallhi TH (2014)

     Excerpt Mallhi TH et al, Hepatoprotective activity of aqueous methanolic extract of Morus nigra against paracetamol-induced hepatotoxicity in mice.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.