Mucuna pruriens (Scratch-and-win) : medicinal properties in alcoholic extraction

Mucuna pruriens (Scratch-and-win, Pwa-graté, Pois-à-gratter) — family Fabacées.

Scientific synonyms : Dolichos pruriens-(L)-DC, var. pruriens, Mucuna Nivea-DC, M cochinchinensis-(L)-A. Chev..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 134 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of myeloid leukaemia, hepatocellular carcinoma, lung cancer, breast cancer and colorectal cancer

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kumar P (2016)

     Excerpt The present study was undertaken to investigate the antiproliferative action of isolated M1 (6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) from Mucuna pruriens seeds using human hepatic carcinoma cell line (Huh-7 cells). M1 was active against Huh-7 cells that may be useful for future hepatic cancer treatment,.

   • According to Obogwu MB (2014)

     Excerpt This study investigated the hepatoprotective & in vivo antioxidant activities of the hydroethanolic extract of Mucuna pruriens leaves in antitubercular & alcohol-induced hepatotoxicity assays in rats. Conclusion: The hydroethanolic extract of MP leaves possesses hepatoprotective activity with enhancement of in vivo antioxidants as a possible mechanism of action.

   • According to Ogunmoloye T (2021)

     Excerpt The present study therefore investigates the hepatoprotective & nephroprotective potentials of its leaves extract with a view to providing a potent alternative in the management of liver & kidney diseases. pruriens leaves restored deranged biochemical & histopathological parameters in the liver & kidney with similar potency to silymarin.

   • According to Concessao P (2020)

     Excerpt Mucuna pruriens has been identified for its medicinal properties. Following the treatment, the blood was drawn retro-orbitally to assess the liver (serum alanine transaminase [ALT], serum aspartate transaminase, & serum alkaline phosphatase) & kidney (serum urea & serum creatinine) functions.

   • According to Garcia VADS (2012)

     Excerpt The main aim of this investigation was to extract oil from seeds of Mucuna in order to increase the concentration of l-Dopa in the defatted Mucuna meal. Three different varieties of Mucuna (aterrima, cinereum, deeringiana) & solvents (supercritical carbon dioxide, dichloromethane, hexane) were used.

2. 2

   Liver disorders: cirrhosis, hepatitis, fatty liver, abnormal serum levels: ALP, ASP, ALT, SOD, CAT, MDA, bilirubin

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Obogwu MB (2014)

     Excerpt This study investigated the hepatoprotective & in vivo antioxidant activities of the hydroethanolic extract of Mucuna pruriens leaves in antitubercular & alcohol-induced hepatotoxicity assays in rats. On the 21(st) day of treatment, blood was collected for assessment of serum biochemical parameters & harvested liver samples were assessed for antioxidants.

   • According to Ogunmoloye T (2021)

     Excerpt pruriens leaves restored deranged biochemical & histopathological parameters in the liver & kidney with similar potency to silymarin. Results Exposure to CCl4 and rifampicin respectively resulted in marked distortion in lipid profile, inhibition of antioxidant enzymes & a surge in ALT, AST, ALP, urea, uric acid, bilirubin & creatine kinase.

   • According to Concessao P (2020)

     Excerpt Following the treatment, the blood was drawn retro-orbitally to assess the liver (serum alanine transaminase [ALT], serum aspartate transaminase, & serum alkaline phosphatase) & kidney (serum urea & serum creatinine) functions. The aim of the study was to investigate the protective effect of aqueous seed extract of MP on sodium arsenite-induced memory impairment, liver, & kidney functions in rats.

   • According to Garcia VADS (2012)

     Excerpt The main aim of this investigation was to extract oil from seeds of Mucuna in order to increase the concentration of l-Dopa in the defatted Mucuna meal. Three different varieties of Mucuna (aterrima, cinereum, deeringiana) & solvents (supercritical carbon dioxide, dichloromethane, hexane) were used.

   • According to Kumar P (2016)

     Excerpt The present study was undertaken to investigate the antiproliferative action of isolated M1 (6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) from Mucuna pruriens seeds using human hepatic carcinoma cell line (Huh-7 cells). M1 was active against Huh-7 cells that may be useful for future hepatic cancer treatment,.

3. 3

   Sexual dysfunction in diabetic patients

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Suresh S (2011)

     Excerpt Male albino rats were divided as group I (sham) control, group II (STZ) diabetes-induced (streptozotocin 60 mg/kg of body weight [bw] in 0.1 M citrate buffer), group III (STZ + MP) diabetic rats administered with 200 mg/kg bw of ethanolic extract of MP seed, group IV (STZ + SIL) diabetic rats administered with 5 mg/kg bw of sildenafil citrate, group V (sham + MP) administered with 200 mg/kg bw of extract alone, & group VI (sham + SIL) administered with 5 mg/kg bw of sildenafil citrate. Mucuna pruriens a leguminous plant identified for its antidiabetic, aphrodisiac, & fertility enhancing properties, has been the choice of Indian traditional medicine.

   • According to Suresh S (2011)

     Excerpt Male albino rats were divided as group I (sham) control, group II (STZ) diabetes-induced (streptozotocin 60 mg/kg of body weight [bw] in 0.1 M citrate buffer), group III (STZ + MP) diabetic rats administered with 200 mg/kg bw of ethanolic extract of MP seed, group IV (STZ + SIL) diabetic rats administered with 5 mg/kg bw of sildenafil citrate, group V (sham + MP) administered with 200 mg/kg bw of extract alone, & group VI (sham + SIL) administered with 5 mg/kg bw of sildenafil citrate. These findings propound to serve mankind by the treatment of diabetes-induced erectile dysfunction.

   • According to Suresh S (2012)

     Excerpt Conclusion: The present work reveals the potential efficacy of ethanolic seed extract of MP to improve male sexual behavior with androgenic & antidiabetic effects in the STZ-induced diabetic male rats. Methods: Male albino rats were divided as group I control, group II diabetes induced (streptozotocin [STZ] 60 mg/kg of body weight (b.w.) in 0.1 M citrate buffer), group III diabetic rats administered with 200 mg/kg b.w.

   • According to Suresh S (2013)

     Excerpt Suresh S et al, Effect of Mucuna pruriens (Linn.) on mitochondrial dysfunction & DNA damage in epididymal sperm of streptozotocin induced diabetic rat, Jl Ethnopharmacol, 145(1):232-41, 2013-Abstarct: Mucuna pruriens Linn. Materials & methods: Male Wistar albino rats were divided as control (Sham), diabetes induced [streptozotocin 60 mg/kg of body weight (b.w.) in 0.1M citrate buffer] (STZ), diabetic rats administered with 200mg/kg b.w.

   • According to SURESH S (2013)

     Excerpt Materials & methods: Male Wistar albino rats were divided as control (Sham), diabetes induced [streptozotocin 60 mg/kg of body weight (b.w) in 0.1 M citrate buffer] (STZ), diabetic rats administered with 200 mg/kg b.w. Aim of the study: To study the effect of ethanolic seed extract of MP on mitochondrial dysfunction & the DNA damage in hyperglycemic rat epididymal spermatozoa.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.