Mucuna pruriens (Pwa-graté) : vertus médicinales en extraction alcoolique

Mucuna pruriens (Pwa-graté, Pois-à-gratter, Scratch-and-win) — famille Fabacées.

Synonymes scientifiques : Dolichos pruriens-(L)-DC, var. pruriens, Mucuna Nivea-DC, M cochinchinensis-(L)-A. Chev..

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 17 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 134 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome myéloïde leucémique, hépatocellulaire, pulmonaire, mammaire & colorectal

   Partie usitée : Semence.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Kumar P (2016)

     Extrait The present study was undertaken to investigate the antiproliferative action of isolated M1 (6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) from Mucuna pruriens seeds using human hepatic carcinoma cell line (Huh-7 cells). M1 was active against Huh-7 cells that may be useful for future hepatic cancer treatment,.

   • Selon Obogwu MB (2014)

     Extrait This study investigated the hepatoprotective & in vivo antioxidant activities of the hydroethanolic extract of Mucuna pruriens leaves in antitubercular & alcohol-induced hepatotoxicity assays in rats. Conclusion: The hydroethanolic extract of MP leaves possesses hepatoprotective activity with enhancement of in vivo antioxidants as a possible mechanism of action.

   • Selon Ogunmoloye T (2021)

     Extrait The present study therefore investigates the hepatoprotective & nephroprotective potentials of its leaves extract with a view to providing a potent alternative in the management of liver & kidney diseases. pruriens leaves restored deranged biochemical & histopathological parameters in the liver & kidney with similar potency to silymarin.

   • Selon Concessao P (2020)

     Extrait Mucuna pruriens has been identified for its medicinal properties. Following the treatment, the blood was drawn retro-orbitally to assess the liver (serum alanine transaminase [ALT], serum aspartate transaminase, & serum alkaline phosphatase) & kidney (serum urea & serum creatinine) functions.

   • Selon Garcia VADS (2012)

     Extrait The main aim of this investigation was to extract oil from seeds of Mucuna in order to increase the concentration of l-Dopa in the defatted Mucuna meal. Three different varieties of Mucuna (aterrima, cinereum, deeringiana) & solvents (supercritical carbon dioxide, dichloromethane, hexane) were used.

2. 2

   Troubles hépatiques : cirrhose, hépatite, stéatose hépatique, anormalité des paramètres sériques : ALP, ASP, ALT, SOD, CAT, MDA, bilirubine

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Obogwu MB (2014)

     Extrait This study investigated the hepatoprotective & in vivo antioxidant activities of the hydroethanolic extract of Mucuna pruriens leaves in antitubercular & alcohol-induced hepatotoxicity assays in rats. On the 21(st) day of treatment, blood was collected for assessment of serum biochemical parameters & harvested liver samples were assessed for antioxidants.

   • Selon Ogunmoloye T (2021)

     Extrait pruriens leaves restored deranged biochemical & histopathological parameters in the liver & kidney with similar potency to silymarin. Results Exposure to CCl4 and rifampicin respectively resulted in marked distortion in lipid profile, inhibition of antioxidant enzymes & a surge in ALT, AST, ALP, urea, uric acid, bilirubin & creatine kinase.

   • Selon Concessao P (2020)

     Extrait Following the treatment, the blood was drawn retro-orbitally to assess the liver (serum alanine transaminase [ALT], serum aspartate transaminase, & serum alkaline phosphatase) & kidney (serum urea & serum creatinine) functions. The aim of the study was to investigate the protective effect of aqueous seed extract of MP on sodium arsenite-induced memory impairment, liver, & kidney functions in rats.

   • Selon Garcia VADS (2012)

     Extrait The main aim of this investigation was to extract oil from seeds of Mucuna in order to increase the concentration of l-Dopa in the defatted Mucuna meal. Three different varieties of Mucuna (aterrima, cinereum, deeringiana) & solvents (supercritical carbon dioxide, dichloromethane, hexane) were used.

   • Selon Kumar P (2016)

     Extrait The present study was undertaken to investigate the antiproliferative action of isolated M1 (6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) from Mucuna pruriens seeds using human hepatic carcinoma cell line (Huh-7 cells). M1 was active against Huh-7 cells that may be useful for future hepatic cancer treatment,.

3. 3

   Impotence sexuelle chez le patient diabétique

   Partie usitée : Semence. Profil pharmacologique documenté : Sildénafil-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Suresh S (2011)

     Extrait Male albino rats were divided as group I (sham) control, group II (STZ) diabetes-induced (streptozotocin 60 mg/kg of body weight [bw] in 0.1 M citrate buffer), group III (STZ + MP) diabetic rats administered with 200 mg/kg bw of ethanolic extract of MP seed, group IV (STZ + SIL) diabetic rats administered with 5 mg/kg bw of sildenafil citrate, group V (sham + MP) administered with 200 mg/kg bw of extract alone, & group VI (sham + SIL) administered with 5 mg/kg bw of sildenafil citrate. Mucuna pruriens a leguminous plant identified for its antidiabetic, aphrodisiac, & fertility enhancing properties, has been the choice of Indian traditional medicine.

   • Selon Suresh S (2011)

     Extrait Male albino rats were divided as group I (sham) control, group II (STZ) diabetes-induced (streptozotocin 60 mg/kg of body weight [bw] in 0.1 M citrate buffer), group III (STZ + MP) diabetic rats administered with 200 mg/kg bw of ethanolic extract of MP seed, group IV (STZ + SIL) diabetic rats administered with 5 mg/kg bw of sildenafil citrate, group V (sham + MP) administered with 200 mg/kg bw of extract alone, & group VI (sham + SIL) administered with 5 mg/kg bw of sildenafil citrate. These findings propound to serve mankind by the treatment of diabetes-induced erectile dysfunction.

   • Selon Suresh S (2012)

     Extrait Conclusion: The present work reveals the potential efficacy of ethanolic seed extract of MP to improve male sexual behavior with androgenic & antidiabetic effects in the STZ-induced diabetic male rats. Methods: Male albino rats were divided as group I control, group II diabetes induced (streptozotocin [STZ] 60 mg/kg of body weight (b.w.) in 0.1 M citrate buffer), group III diabetic rats administered with 200 mg/kg b.w.

   • Selon Suresh S (2013)

     Extrait Suresh S et al, Effect of Mucuna pruriens (Linn.) on mitochondrial dysfunction & DNA damage in epididymal sperm of streptozotocin induced diabetic rat, Jl Ethnopharmacol, 145(1):232-41, 2013-Abstarct: Mucuna pruriens Linn. Materials & methods: Male Wistar albino rats were divided as control (Sham), diabetes induced [streptozotocin 60 mg/kg of body weight (b.w.) in 0.1M citrate buffer] (STZ), diabetic rats administered with 200mg/kg b.w.

   • Selon SURESH S (2013)

     Extrait Materials & methods: Male Wistar albino rats were divided as control (Sham), diabetes induced [streptozotocin 60 mg/kg of body weight (b.w) in 0.1 M citrate buffer] (STZ), diabetic rats administered with 200 mg/kg b.w. Aim of the study: To study the effect of ethanolic seed extract of MP on mitochondrial dysfunction & the DNA damage in hyperglycemic rat epididymal spermatozoa.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.