Nerium oleander (Lôyé-wôz) : medicinal properties in alcoholic extraction

Nerium oleander (Lôyé-wôz, oleander, laurier rose) — family Apocynacées.

Scientific synonyms : Nerium flavescens-Spin, N indicum-Mill, N japonicum-Gentil, Oleander indica (Mill.) Medik, Oleander Indica-(Mill)-Medik, O. vulgaris Medik..

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 121 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sikarwar MS (2009)

     Excerpt This research aims to investigate the antidiabetic activity of Nerium indicum leaf extract in alloxan induced diabetic albino rats. In alloxan induced model, blood glucose level of these extracts on the seventh day of study were NICE (113.33±6.662) & NIEE (169.33±9.735) in comparison of diabetic control (413.50 ±4.752) & petroleum ether extract (337.83±25.515).

   • According to Ayaz M (2015)

     Excerpt Protective and restorative effects of distillated Nerium oleander (NO) on the diabetes-induced electrophysiological & structural alterations were investigated. Distillated N oleander (NO) can be a highly potential therapeutic or preventive agent on the diabetes induced excitation-contraction coupling alterations Patent No: WO/2010/082906.

   • According to Levent Bas A (2012)

     Excerpt Type 2 diabetic Nerium-oleander- (NO-) administered groups received the NO distillate at a dose of 3.75, 37.5, & 375 μg/0.5 mL of distilled water (NO-0.1, NO-1, NO-10, resp.); positive control group had 0.6 mg glibenclamide/kg bw/d by gavage daily for 12 weeks. Diabetes was induced by intraperitoneal injection of streptozotocin (35 mg/kg bw) in all rats of 5 groups after being fed for 2 weeks high-fat diet.

   • According to Ayaz M (2012)

     Excerpt The current study aims to investigate the possible role of Nerium oleander (NeOL) distillate in the treatment of diabetic neuropathy. Induction of diabetes was done by the combination of single dose streptozotocin injection together with a high fat diet for four weeks.

   • According to Basak Yanardag S (2015)

     Excerpt The current study aims to investigate the possible role of Nerium oleander (NeOL) distillate in the treatment of diabetic neuropathy. Induction of diabetes was done by the combination of single dose streptozotocin injection together with a high fat diet for four weeks.

2. 2

   Bacterial infection: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Erwich, E (2010)

     Excerpt Escherichia coli, Pseudomonas aeruginosa & Staphylococcus aureus were used as test bacterial strains. The objective of this work is to investigate the main chemical composition and antibacterial activity of Nerium oleander flowers growing in Morocco.

   • According to Fartyal M (2014)

     Excerpt The present study was designed to evaluate the antibacterial activity of crude extracts of Nerium oleander Crude extracts from different parts (root, stem & leaf) of the plant were extracted using polar (Water & Methanol) & Non-polar (Petroleum ether) solvents & were screened for antibacterial activity by „Disc Diffusion Assay‟ against three Gram negative bacteria (Escherichia coli, Klebsiella pneumoniae & Agrobacterium tumifaciens) & two Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis). Pet ether extract of root (IZ=24 mm, MIC=0.078 mg/ml, MBC=0.039 mg/ml, TA=141.02 ml/g) & stem (IZ=20 mm, MIC=0.156 mg/ml, MBC= 0.078 mg/ml, TA= 16.02 ml/g) showed the best antibacterial activity against B.

   • According to Fartyal M (2014)

     Excerpt Results of the present study reveal that extracts of NO have great antimicrobial potential against tested microorganisms, & may be exploited for future antimicrobial drugs. subtilis (IZ=14 mm, MIC=0.312mg/ml, MBC= 0.156mg/ml, TA=62.5ml/g), similarly Free flavonoid extract of root were best against B.

   • According to Ma YM (2017)

     Excerpt Among them, compound 2 revealed potent antibacterial activity against Staphylococcus aureus with MIC value of 15.6 μg/mL. Meanwhile, the antibacterial & antifungal activities of all compounds were tested, & the results showed that three compounds had strong antifungal activity.

   • According to Saranya S (2017)

     Excerpt In the present study, the antimicrobial & antioxidant properties of the flower extract of Nerium oleander were evaluated as a remedy for pathogenic diseases. The findings indicated that N oleander flowers have various phytopharmacological activities & thus it would be useful for the treatment of various diseases in future.

3. 3

   Tomato blight: Sclerotium rolfsii, Fusarium oxysporum

   Plant part used: Pest control and veterinary products.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Siddiqui L (2016)

     Excerpt Nerium oleander was screened for antifungal activity against three economically important fungi Macrophomina phaseolina, Sclerotium rolfsii & Fusarium oxysporum, leaves stem & root extracts in aqueous, methanol, ethanol, choloroform & acetone were prepared & were evaluated for their in vitro antifungal ability. oxysporum trend has entirely changed, shoot induced the maximum effect as the diameter of the fungal colony was 0.37 in acetone; this trend was followed by chloroform & ethanol shoot extracts respectively.

   • According to Fartyal M (2014)

     Excerpt The present study was designed to evaluate the antibacterial activity of crude extracts of Nerium oleander Crude extracts from different parts (root, stem & leaf) of the plant were extracted using polar (Water & Methanol) & Non-polar (Petroleum ether) solvents & were screened for antibacterial activity by „Disc Diffusion Assay‟ against three Gram negative bacteria (Escherichia coli, Klebsiella pneumoniae & Agrobacterium tumifaciens) & two Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis). Pet ether extract of root (IZ=24 mm, MIC=0.078 mg/ml, MBC=0.039 mg/ml, TA=141.02 ml/g) & stem (IZ=20 mm, MIC=0.156 mg/ml, MBC= 0.078 mg/ml, TA= 16.02 ml/g) showed the best antibacterial activity against B.

   • According to Saranya S (2017)

     Excerpt In the present study, the antimicrobial & antioxidant properties of the flower extract of Nerium oleander were evaluated as a remedy for pathogenic diseases. The findings indicated that N oleander flowers have various phytopharmacological activities & thus it would be useful for the treatment of various diseases in future.

   • According to Erwich, E (2010)

     Excerpt The objective of this work is to investigate the main chemical composition and antibacterial activity of Nerium oleander flowers growing in Morocco. To evaluate the antibacterial activities of these aromatic extracts; there in vitro antibacterial activities were determined by disk diffusion testing and minimum inhibitory concentration (MIC).

   • According to Ma YM (2017)

     Excerpt Meanwhile, the antibacterial & antifungal activities of all compounds were tested, & the results showed that three compounds had strong antifungal activity. Among them, compound 2 revealed potent antibacterial activity against Staphylococcus aureus with MIC value of 15.6 μg/mL.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.