Nigella sativa (Tjimen nwè) : medicinal properties in alcoholic extraction

Nigella sativa (Tjimen nwè, Black cumin, Cumin noir) — family Renonculacées.

Scientific synonyms : Nigella sativa-L, var sativa.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 337 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Aortic vasoconstriction in people with diabetes

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Abbasnezhad A (2016)

     Excerpt The present study investigated the effects of hydroalcoholic extract of Nigella sativa on contractile dilatation response of isolated aorta in streptozotocin (STZ)-induced diabetic rat. Conclusion: Chronic administration of NS seed extract has a significant hypoglycemic effect & improves aortic reactivity to vasoconstrictor & vasodilator agents in STZ-induced diabetic rats.

   • According to Khan A (2011)

     Excerpt The crude oil & thymoquinone (TQ) extracted from its seeds and oil are effective against many diseases like cancer, cardiovascular complications, diabetes, asthma, kidney disease etc. Nigella sativa has been used as traditional medicine for centuries.

   • According to Hadj V (2021)

     Excerpt Nigella sativa in controlling Type 2 diabetes, cardiovascular, & rheumatoid arthritis diseases: Molecular aspects, Jl Res Med Sci, 31:26:20.2021-Abtract: Oxidative stress is an important factor in the etiology of several chronic diseases that include cardiovascular disease (CVD), Type 2 diabetes (T2D), & rheumatoid arthritis (RA). One of the treatment options for chronic diseases is the use of traditional medicine & herbs, such as Nigella sativa.

   • According to Shafiq H (2014)

     Excerpt Nigella sativa is the miraculous plant having a lot of nutritional & medicinal benefits, & attracts large number of nutrition & pharmacological researchers. NS is rich source of different biologically active compounds & is found effective in controlling number of cardiovascular diseases & various cancers both in vivo & in vitro studies,.

   • According to Dara-khan S (2015)

     Excerpt In addition, positive effects of TQ in cardiovascular disorders, diabetes, reproductive disorders & respiratory ailments, as well as in the treatment of bone complications as well as fibrosis have been shown. Thymoquinone (TQ) is the most abundant constituent of the volatile oil of Nigella sativa seeds & most properties of NS are mainly attributed to TQ.

2. 2

   Diabetic foot, skin ulcer

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mirazi N (2019)

     Excerpt The aim of this study was to investigate the effect of hydroethanolic Nigella sativa L. extract on skin wound healing in diabetic male rats.

   • According to Salahuddin N (2020)

     Excerpt Nigella sativa (NS) has been reported to have a therapeutic effect towards skin wound healing via its anti-inflammatory, tissue growth stimulation, and antioxidative properties. This review examines all the available studies on the association of Nigella sativa (NS) and skin wound healing.

   • According to Abbasnezhad A (2016)

     Excerpt The present study investigated the effects of hydroalcoholic extract of Nigella sativa on contractile dilatation response of isolated aorta in streptozotocin (STZ)-induced diabetic rat. Conclusion: Chronic administration of NS seed extract has a significant hypoglycemic effect & improves aortic reactivity to vasoconstrictor & vasodilator agents in STZ-induced diabetic rats.

   • According to Khan A (2011)

     Excerpt Nigella sativa has been used as traditional medicine for centuries. The crude oil & thymoquinone (TQ) extracted from its seeds and oil are effective against many diseases like cancer, cardiovascular complications, diabetes, asthma, kidney disease etc.

   • According to Tiwari O (2024)

     Excerpt TQ is the main phytoconstituent present in NS that is used as an herbal compound, & it is widely used as an antihypertensive, liver tonic, diuretic, digestive, anti-diarrheal, appetite stimulant, analgesic, & antibacterial agent, & in skin disorders. Methods: Antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, hepato-protective, renal protective, & antioxidant properties of TQ have been studied by various scientists.

3. 3

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Khan A (2011)

     Excerpt Nigella sativa has been used as traditional medicine for centuries. The crude oil & thymoquinone (TQ) extracted from its seeds and oil are effective against many diseases like cancer, cardiovascular complications, diabetes, asthma, kidney disease etc.

   • According to Ali-Mohammadi S (2013)

     Excerpt The present study investigated the effects of Nigella sativa hydroalcoholic extract on glucose concentrations in streptozotocin (STZ) diabetic rats. These results showed that hydroalcoholic extract of NS at low doses has hypoglycemic effect & ameliorative effect on regeneration of pancreatic islets & may be used as a therapeutic agent in the management of diabetes mellitus.

   • According to Mirazi N (2019)

     Excerpt The aim of this study was to investigate the effect of hydroethanolic Nigella sativa L. Methods This experimental study was conducted on 49 male Wistar rats weighing 220–250 g divided into 7 groups of 7 each: control (nondiabetic untreated), sham (nondiabetic Eucerin-treated), nondiabetic phenytoin (1%)-treated, diabetic untreated, & three diabetic groups treated independently with phenytoin 1%, hydroethanolic NS extracts 20% or 40%.

   • According to Abbasnezhad A (2015)

     Excerpt The aim of this study was to investigate the effects of hydroalcoholic extract of Nigella sativa seed on oxidative stress in STZ-induced diabetic rats' hippocampus. Materials & methods: Diabetes induced by 60 mg/kg STZ, i.p, & the rats were divided into five experimental groups (n=8-10 in each group) including control (received 0.5 ml normal saline), untreated STZ-diabetic (received 0.5 ml normal saline), & treated rats received NS extract (200 & 400 mg/kg) or metformin (300 mg/kg) by gavage for 42 days.

   • According to Abbasnezhad A (2016)

     Excerpt The present study investigated the effects of hydroalcoholic extract of Nigella sativa on contractile dilatation response of isolated aorta in streptozotocin (STZ)-induced diabetic rat. Conclusion: Chronic administration of NS seed extract has a significant hypoglycemic effect & improves aortic reactivity to vasoconstrictor & vasodilator agents in STZ-induced diabetic rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.