Ocimum tenuiflorum (Tulsi) : medicinal properties in alcoholic extraction

Ocimum tenuiflorum (Tulsi, Holy Basil from India, Toulsi, Basilic Sacré de l’Inde) — family Lamiacées.

Scientific synonyms : Ocimum sanctum –L.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 34 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 113 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Indication

   Plant part used: Sheet. Mentioned synergistic association: Eugenia jambolana-semence, Momordica charantia-fruit,.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kumar C (2020)

     Excerpt The effect of hydroalcoholic extract of poly herbal preparation containing seeds of Eugenia jambolana, fruits of Momordica charantia, & leaves of Ocimum sanctum was investigated in normal, glucose load conditions & alloxan induced diabetic rats. The objective of this study is to induce experimental diabetes mellitus using Alloxan in normal Albino Wistar rats & study the anti-diabetic activity of polyherbal formulation by comparison of changes in body weight & levels of glucose between normal & diabetic rats.

   • According to Rao A (2013)

     Excerpt The aim of the study was to evaluate the anti-diabetic activity of ethanolic extract of leaves of plant Ocimum sanctum in alloxan induced diabetes in rats. Diabetes mellitus refers to a group of common metabolic disorders that Share the phenotype of hyperglycaemia resulting from defects of reduced insulin secretion, decreased glucose utilization and increase in glucose production.

   • According to Parasuraman S (2015)

     Excerpt The oral anti-diabetic activity of the hydroalcoholic extract of OT (125, 250 & 500 mg/kg) was studied against streptozotocin (STZ) (50 mg/kg; i.p.) + nicotinamide (120 mg/kg; i.p.) induced diabetes mellitus. Conclusion: The hydroalcoholic extract of OT showed significant anti-diabetic & anti-hyperlipidemic activity against STZ + nicotinamide induced diabetes mellitus in rats.

   • According to Vats V (2004)

     Excerpt Ocimum sanctum (OS) has been mentioned in Indian system of traditional medicine to be of value in the treatment of diabetes mellitus. The present study was undertaken to assess the effect of OS on three important enzymes of carbohydrate metabolism [glucokinase (GK) (EC 2.7.1.2), hexokinase (HK) (EC 2.7.1.1) & phospho-fructokinase (PFK) (EC 2.7.1.11)] along with glycogen content of insulin-dependent (Skeletal muscle and liver) and insulin-independent tissues (kidneys and Brain) in STZ (65 mg/kg) induced model of diabetes for 30 days.

   • According to Kamyab AA (2013)

     Excerpt In modern era, it has been shown to be effective against diabetes mellitus, hypertension, cancers, bronchitis, & found to have anti-microbial properties.

2. 2

   Hepatitis, fatty liver disease

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lahon K (2011)

     Excerpt Reduction in sinusoidal congestion, cloudy swelling & fatty changes & regenerative areas of the liver were observed on histopathological examination in groups C, D & E, whereas group B showed only hepatic necrosis. The hepatoprotective effect was evaluated by performing an assay of the serum proteins, albumin globulin ratio, alkaline phosphatase, transaminases & liver histopathology.

   • According to Kamyab AA (2013)

     Excerpt In liver, essential oils & extracts of OS could prevent oxidative stress by increasing glutathione peroxidae & catalase & were also effective in prevention of hepatic steatosis. Recently its efficacy against inflammatory response, hepatic injury & gastric ulcer has been elucidated in animal studies.

   • According to Author (1995)

     Excerpt Both oleanolic acid & ursolic acid are effective in protecting against chemically induced liver injury in Laboratory animals. Oleanolic acid has been marketed in China as an oral drug for human liver disorders.

   • According to VENU PRASAD (2012)

     Excerpt The OS treatment was found to lower Malondialdehyde (MDA) & lactic acid levels in liver and muscle tissues compared with control exercise group (p<0.05).

   • According to Sharma L (2018)

     Excerpt On the last day of the protocol, rats were sacrificed by cervical dislocation liver, kidney & brain were isolated & preserved in formalin for further histopathological examination.

3. 3

   Indication

   Plant part used: Sheet. Mentioned synergistic association: Azadirachta Indica-feuille.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Boonyanugomol W (2021)

     Excerpt The effects of Ocimum tenuiflorum essential oil (OTEO) against gastric cancer remain unknown and merit investigation. Conclusions: This in vitro study demonstrates for the first time that OTEO has potential anti-gastric cancer activity & may induce apoptosis in AGS cells through extrinsic & intrinsic pathway.

   • According to Jha AK (2012)

     Excerpt It was observed that the treatment of a squamous cervical cancer cell line, SiHa with the ethanolic extracts of leaves of Ocimum sanctum & Azadirachta indica & roots of Withania somnifera at IC50 values for 48 h resulted in formation of internucleosomal fragments of DNA. These results clearly show that these plant extracts, which have previously been shown to have anticarcinogenic activity, can induce apoptosis in SiHa, a cervical cancer cell line.

   • According to Manikandan P (2008)

     Excerpt We investigated the combinatorial chemopreventive efficacy of Azadirachta indica (AI) & Ocimum sanctum (OS) against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis, based on changes in oxidant-antioxidant status, cell proliferation, apoptosis & angiogenesis. Coadministration of AI & OS extract suppressed MNNG-induced gastric carcinomas accompanied by modulation of the oxidant-antioxidant status, inhibition of cell proliferation & angiogenesis, & induction of apoptosis.

   • According to Magesh V (2009)

     Excerpt Therefore, the antitumor mechanism of ethanol extracts of Ocimum sanctum (EEOS) was elucidated in A549 cells in vitro & the Lewis lung Carcinoma (LLC) animal model. Although Ocimum sanctum has been used extensively for its medicinal values in India & China, its antitumor activity against human non-small cell lung Carcinoma (NSCLC) A549 cells has not been investigated until now.

   • According to KARTIKEYAN K (1999)

     Excerpt Administration of aqueous & ethanolic extracts of O sanctum to mice bearing Sarcoma-180 solid tumors mediated a significant reduction in tumor volume & an increase in lifespan. These observations clearly indicate O sanctum extracts possess anticancer activity.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.