Olea europaea (Zolivié) : medicinal properties in alcoholic extraction

Olea europaea (Zolivié, Olivier) — family Oleacacées.

Scientific synonyms : Olea europaea subsp. Africana-(Mill)-P.S. Green, O europaea var. buxifolia-Sol, europaea subsp. Cerasiforme-G.K. & S, var picholine marocaine, var Corregiola & Frantoio.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 19 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 102 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Omer Musa Izzy Eldin (2015)

     Excerpt The effect of 200,400 & 800 mg/kg of ethanolic extract of Olea europaea leaves was evaluated in both glucose-loaded Wistar albino rats & in glucose uptake by using isolated rats hemidiaphragms. Their effects were compared to control rats administered with the vehicle & to a standard group administered with the standard drug Glibenclamide.

   • According to FARAH SH (2015)

     Excerpt The effect of ethanolic extraction of olive leaves on alloxan – induced diabetic rabbits and lipid profile has been investigated. The maximum hypoglycemic activity (about 20% reduction in blood glucose level) was obtained from the treatment of diabetic rabbits with 600mg/ kg.

   • According to Eidi A (2009)

     Excerpt The antidiabetic effect of an alcohol extract of olive (Olea europaea L.) leaves was investigated in normal & streptozotocin-induced diabetic rats. The oral administration of the olive leaves extract (0.1, 0.25 & 0.5 g/kg body wt) for 14 days significantly decreased the serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate amino transferase (AST) & alanine amino transferase (ALT) while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05).

   • According to Sato H (2007)

     Excerpt Olive tree (Olea europaea) leaves are well known for their effect on metabolism in particular as a traditional anti-diabetic & anti-hypertensive herbal drug. Our data suggest that both oleuropein & oleanolic acid are involved in the anti-diabetic effect of olive leaves & further emphasize the potential role of TGR5 agonists to improve metabolic disorders.

   • According to Zeytünlüoğlu A (2015)

     Excerpt Dipeptidyl peptidase IV (DPP IV) is a serine amino (exo) peptidase which regulates various processes most notably plasma glucose homeostasis by cleaving incretin peptide hormones as glucagon-like peptide-1 (GLP-1) & glucose-dependent insulin releasing polypeptide (GIP). The present study was designed to investigate the DPP IV inhibitory effects of sixteen plants having antidiabetic property in aqueous extracts in correlation with their protein content.

2. 2

   Bacterial infection: E. coli, Pasteurella multocida, Bacillus cereus, Salmonella Enteritidis and Mycoplasma gallisepticum

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to HEMEG HA (2020)

     Excerpt This study evaluates the antimicrobial effects of ethanolic extract of five herbal plants; Guava (Psidium guajava), Sage (Salvia officinalis), Rhamnus (Ziziphus-spina Christi), Mulberry (Morus alba L.), & Olive (Olea europaea L) leaves against several microbial population representing Gram positive, Gram negative & Mollicutes; S. cereus, Salmonella Enteritidis & Mycoplasma.

   • According to Hassan A (2020)

     Excerpt coli, Pasteurella multocida, Bacillus cereus, Salmonella Enteritidis & Mycoplasma gallisepticum using standard agar disc diffusion technique & minimal inhibitory concentration (MIC). This study evaluates the antimicrobial effects of ethanolic extract of five herbal plants; Guava (Psidium guajava), Sage (Salvia officinalis), Rhamnus (Ziziphus spina Christi), Mulberry (Morus alba L.), & Olive (Olea europaea L) leaves against several microbial population representing Gram positive, Gram negative & Mollicutes; S.

   • According to Pereira A.P (2007)

     Excerpt We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, & the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal & respiratory tract infections, namely gram positive (Bacillus cereus, B. At low concentrations olive leaves extracts showed an unusual combined antibacterial & antifungal action, which suggest their great potential as nutraceuticals, particularly as a source of phenolic compounds.

   • According to ZAFAR A (2010)

     Excerpt The synergy of these antibiotics with the ethanolic extracts of stem & leaf of Olea Europaea was also investigated. The combination of stem & leaf extract with Penicillin (23.O mm & 22.5 mm respectively), could not produce the same inhibitory effect as that of Chloramphenicol & O europaea stem & leaf extracts.

   • According to BAYCIN D (2007)

     Excerpt Silk fibroin also gained antimicrobial activity against Staphylococcus aureus & Klebsiella pneumoniae after adsorption of olive leaf antioxidants.

3. 3

   Cancer: adjuvant treatment for pancreatic carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Goldsmith CD (2015)

     Excerpt Therefore, water, 50% ethanol & 50% methanol extracts of Corregiola & Frantoio variety O-europaea leaves were investigated for their total phenolic compounds, total flavonoids & Oleuropein content, antioxidant capacity & anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, & at 100 & 200 μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls.

   • According to Giner E (2016)

     Excerpt The main phenolic secoiridoid oleuropein and active constituent from olive tree (Olea europaea, Oleaceae), has demonstrated anti-inflammatory properties in intestinal inflammation & anti-tumoral effects in different cancer cells. In this study, we evaluated the chemoprevention of oleuropein in a model of azoxymethane (AOM)/Dextran sulfate sodium (DSS)-induced colorectal cancer (CRC) in C57BL/6 mice & the modulatory effect on the Th17 response in DSS acute colitis.

   • According to Abaza L (2007)

     Excerpt The protective effects of olive (Olea europaea L.) leaves were investigated by incubating human promyelocytic leukemia HL-60 cells with olive leaf extracts (OLEs) from seven principal Tunisian olive varieties, namely, Chemchali, Chemlali, Chétoui, Gerboui, Sayali, Zalmati & Zarrazi. Cancer protection associated with the consumption of olive products is well established, but not for leukemia.

   • According to Fares (2011)

     Excerpt In this study, the anti-proliferative activity of plant extracts from olive (Olea europaea L.) leaves was tested on human leukemic cell line (Jurkat). It is becoming increasingly evident that certain phytochemicals possess cancer chemopreventive properties.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.