Origanum majorana (Marjoram) : medicinal properties in alcoholic extraction

Origanum majorana (Marjoram, Marjolaine) — family Lamiacées.

Scientific synonyms : Majorana hortensis-Moench.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 28 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 87 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for colorectal and liver carcinoma and fibrosarcoma

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to FATTY SA (2016)

     Excerpt This study aimed to investigate the antiproliferative effect of aqueous and ethanol extracts of Origanum majorana leaf on human hepatocellular carcinoma (HepG2) cell line through incubation of various concentrations of Origanum majorana extracts with HepG2 and at different time intervals. Hepatocellular carcinoma (HCC) is one of the most common cancer types with a high prevalence and it is the leading cause of cancer deaths worldwide.

   • According to Abdel-Tawab H (2013)

     Excerpt This study was carried out to evaluate the adverse effects of exposure to Prallethrin on oxidant/antioxidant status & liver dysfunction biomarkers and the protective role of Origanum majorana essential oil (EO) in rat. It caused increase in thiobarbituric acid reactive substances and reduction in the activities of superoxide dismutase, catalase, & glutathione-S-transferase in liver.

   • According to Al Dhaheri Y (2013)

     Excerpt In the present study, we investigated the effect of Origanum majorana ethanolic extract on the survival of the highly proliferative & invasive triple-negative p53 mutant breast cancer cell line MDA-MB-231. majorana may be a promising chemopreventive & therapeutic candidate against cancer especially for highly invasive triple negative p53 mutant breast cancer; thus, validating its complementary & alternative medicinal use,.

   • According to Benhalilou N (2019)

     Excerpt In the present study, we investigated the potential anticancer effect & the molecular mechanism of Origanum majorana ethanolic extract (OME) against human colorectal cancer cells. We showed that OME exhibited strong anti-proliferative activity in a concentration- and time-dependent manner against two human colorectal cancer cell lines (HT-29 & Caco-2).

   • According to Athamneh K (2020)

     Excerpt Here we have investigated the anti-colon cancer potential of Origanum majorana essential oil (OMEO) & its underlying mechanisms of action. We showed that OMEO significantly inhibited the cellular viability & colony growth of human HT-29 colorectal cancer cells.

2. 2

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to TRIPATHY B (2018)

     Excerpt The prominent objective of this work was to find out the antidiabetic & anti-hyperlipidemic activities of Origanum majorana ethanol leaf extract (100, 200, 400 mg/kg body weight) in Streptozotocin (50 mg/kg b.w) induced diabetic rats. Diabetes mellitus or sugar diabetes is a condition that occurs when the body can’t use glucose (a type of sugar) normally.

   • According to Pimple BP (2012)

     Excerpt Streptozotocin, STZ (65 mg/Kg, i.p.) along with nicotinamide (120 mg/kg, i.p.) was used to induce non-insulin dependent diabetes mellitus (NIDDM) in rats. The present study deals with phytochemical, antioxidant, antihyperglycaemic & antihyperlipidemic potential of Origanum majorana (OM) leaves.

   • According to Author (2012)

     Excerpt Perez Gutierrez RM, Inhibition of Advanced Glycation End-Product Formation by Origanum majorana L. In Vitro & in Streptozotocin-Induced Diabetic Rats, Evidence-Based Comp & Alter Med, 2012.

   • According to Moghaddam M G (2013)

     Excerpt Moghaddam M G et al, The Effects of Origanum Majorana on Oxidative Stress & Histopathology of Renal Tissue among Streptozotocin-Induced Diabetic Rats, Thrita.

3. 3

   Hepatitis, fatty liver, cirrhosis

   Plant part used: aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to FATTY SA (2016)

     Excerpt This study aimed to investigate the antiproliferative effect of aqueous and ethanol extracts of Origanum majorana leaf on human hepatocellular carcinoma (HepG2) cell line through incubation of various concentrations of Origanum majorana extracts with HepG2 and at different time intervals. Hepatocellular carcinoma (HCC) is one of the most common cancer types with a high prevalence and it is the leading cause of cancer deaths worldwide.

   • According to Abdel-Tawab H (2013)

     Excerpt This study was carried out to evaluate the adverse effects of exposure to Prallethrin on oxidant/antioxidant status & liver dysfunction biomarkers and the protective role of Origanum majorana essential oil (EO) in rat. It caused increase in thiobarbituric acid reactive substances and reduction in the activities of superoxide dismutase, catalase, & glutathione-S-transferase in liver.

   • According to El-Ashmawy IM (2007)

     Excerpt Marjoram volatile oil (Origanum majorana L., Lamiaceae) & grape seed extract (Vitis vinifera L., Vitaceae) are potent antioxidants. Effects of administration of marjoram volatile oil or grape seed extract on oral administration of ethanol, simultaneously, daily for 10 weeks were studied through determining epididymal spermatozoal analysis, serum testosterone level, weight and histopathological examination of testis, liver and brain.

   • According to DESOUKY S (2015)

     Excerpt Therefore, the present study investigated the curative effect of Origanum majorana ethanolic extract (OMEE) on the lipid profile abnormalities induced by cisplatin. Origanum majorana is a natural herbal product used in the management of many diseases.

   • According to Makrane H (2018)

     Excerpt The toxicity of the aqueous extract of Origanum majorana was tested (5 & 10 g/kg) in albino mice. All extracts (aqueous, petroleum ether, dichloromethane, ethyl acetate, methanolic & depleted aqueous extracts) of O majorana tested against both types of cancer cells showed a more pronounced cytotoxic effect against breast cell line MDA-MB-231 than colon cells line HT-29 cells.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.