Origanum majorana (Marjolaine) : vertus médicinales en extraction alcoolique

Origanum majorana (Marjolaine) — famille Lamiacées.

Synonymes scientifiques : Majorana hortensis-Moench.

Sources externes reconnues associées à cette monographie : TRAMIL et Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 28 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 87 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome colorectal, hépatique & fibrosarcome

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon FATTY SA (2016)

     Extrait This study aimed to investigate the antiproliferative effect of aqueous and ethanol extracts of Origanum majorana leaf on human hepatocellular carcinoma (HepG2) cell line through incubation of various concentrations of Origanum majorana extracts with HepG2 and at different time intervals. Hepatocellular carcinoma (HCC) is one of the most common cancer types with a high prevalence and it is the leading cause of cancer deaths worldwide.

   • Selon Abdel-Tawab H (2013)

     Extrait This study was carried out to evaluate the adverse effects of exposure to Prallethrin on oxidant/antioxidant status & liver dysfunction biomarkers and the protective role of Origanum majorana essential oil (EO) in rat. It caused increase in thiobarbituric acid reactive substances and reduction in the activities of superoxide dismutase, catalase, & glutathione-S-transferase in liver.

   • Selon Al Dhaheri Y (2013)

     Extrait In the present study, we investigated the effect of Origanum majorana ethanolic extract on the survival of the highly proliferative & invasive triple-negative p53 mutant breast cancer cell line MDA-MB-231. majorana may be a promising chemopreventive & therapeutic candidate against cancer especially for highly invasive triple negative p53 mutant breast cancer; thus, validating its complementary & alternative medicinal use,.

   • Selon Benhalilou N (2019)

     Extrait In the present study, we investigated the potential anticancer effect & the molecular mechanism of Origanum majorana ethanolic extract (OME) against human colorectal cancer cells. We showed that OME exhibited strong anti-proliferative activity in a concentration- and time-dependent manner against two human colorectal cancer cell lines (HT-29 & Caco-2).

   • Selon Athamneh K (2020)

     Extrait Here we have investigated the anti-colon cancer potential of Origanum majorana essential oil (OMEO) & its underlying mechanisms of action. We showed that OMEO significantly inhibited the cellular viability & colony growth of human HT-29 colorectal cancer cells.

2. 2

   Diabète mellitus de type II

   Partie usitée : Feuille. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon TRIPATHY B (2018)

     Extrait The prominent objective of this work was to find out the antidiabetic & anti-hyperlipidemic activities of Origanum majorana ethanol leaf extract (100, 200, 400 mg/kg body weight) in Streptozotocin (50 mg/kg b.w) induced diabetic rats. Diabetes mellitus or sugar diabetes is a condition that occurs when the body can’t use glucose (a type of sugar) normally.

   • Selon Pimple BP (2012)

     Extrait Streptozotocin, STZ (65 mg/Kg, i.p.) along with nicotinamide (120 mg/kg, i.p.) was used to induce non-insulin dependent diabetes mellitus (NIDDM) in rats. The present study deals with phytochemical, antioxidant, antihyperglycaemic & antihyperlipidemic potential of Origanum majorana (OM) leaves.

   • Selon Auteur (2012)

     Extrait Perez Gutierrez RM, Inhibition of Advanced Glycation End-Product Formation by Origanum majorana L. In Vitro & in Streptozotocin-Induced Diabetic Rats, Evidence-Based Comp & Alter Med, 2012.

   • Selon Moghaddam M G (2013)

     Extrait Moghaddam M G et al, The Effects of Origanum Majorana on Oxidative Stress & Histopathology of Renal Tissue among Streptozotocin-Induced Diabetic Rats, Thrita.

3. 3

   Hépatite, stéatose hépatique, cirrhose

   Partie usitée : Parties aériennes.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon FATTY SA (2016)

     Extrait This study aimed to investigate the antiproliferative effect of aqueous and ethanol extracts of Origanum majorana leaf on human hepatocellular carcinoma (HepG2) cell line through incubation of various concentrations of Origanum majorana extracts with HepG2 and at different time intervals. Hepatocellular carcinoma (HCC) is one of the most common cancer types with a high prevalence and it is the leading cause of cancer deaths worldwide.

   • Selon Abdel-Tawab H (2013)

     Extrait This study was carried out to evaluate the adverse effects of exposure to Prallethrin on oxidant/antioxidant status & liver dysfunction biomarkers and the protective role of Origanum majorana essential oil (EO) in rat. It caused increase in thiobarbituric acid reactive substances and reduction in the activities of superoxide dismutase, catalase, & glutathione-S-transferase in liver.

   • Selon El-Ashmawy IM (2007)

     Extrait Marjoram volatile oil (Origanum majorana L., Lamiaceae) & grape seed extract (Vitis vinifera L., Vitaceae) are potent antioxidants. Effects of administration of marjoram volatile oil or grape seed extract on oral administration of ethanol, simultaneously, daily for 10 weeks were studied through determining epididymal spermatozoal analysis, serum testosterone level, weight and histopathological examination of testis, liver and brain.

   • Selon DESOUKY S (2015)

     Extrait Therefore, the present study investigated the curative effect of Origanum majorana ethanolic extract (OMEE) on the lipid profile abnormalities induced by cisplatin. Origanum majorana is a natural herbal product used in the management of many diseases.

   • Selon Makrane H (2018)

     Extrait The toxicity of the aqueous extract of Origanum majorana was tested (5 & 10 g/kg) in albino mice. All extracts (aqueous, petroleum ether, dichloromethane, ethyl acetate, methanolic & depleted aqueous extracts) of O majorana tested against both types of cancer cells showed a more pronounced cytotoxic effect against breast cell line MDA-MB-231 than colon cells line HT-29 cells.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.