Origanum vulgare (Oregano) : medicinal properties in alcoholic extraction

Origanum vulgare (Oregano, Origan) — family Lamiacées.

Scientific synonyms : Majorana neglecta-(V)-W, Origanum hirtum L, O Illyricum-S, O megastachyum-L, O neglectum-V, O smymaeum-Sm, O vulgare var megastachyum-(L)-WDJ Koch.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 55 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: Acinetobacter baumannii, Bacillus subtilis, Bordetella bronchiseptica, Pseudomonas aeruginosa, Staphylococcus aureus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Liçina BZ (2013)

     Excerpt The strongest antibacterial activity, determined by microdilution method, was detected on G+ bacteria such as Bacillus species & Staphylococcus aureus, obtaining minimal inhibitory concentration (MIC) 0.16 mg/ml while antifungal activity was moderate with MICs between 2.5 & 20 mg/mL. The present work was undertaken to determine the total phenol, flavonoid & tannin content in five extracts of Origanum vulgare growing wild in southwest Serbia as well as to evaluate antioxidant & antimicrobial activity towards 29 strains of human pathogenic & food spoilage bacteria & fungi.

   • According to Puskarova A (2017)

     Excerpt The in vitro antibacterial activity of six EOs against bacterial strains from both clinical and environmental origins (both Gram-positive & Gram-negative bacteria) was assayed using the disc diffusion method by measuring inhibition zone diameters (Fig. The differences in the measured inhibition halos of OR (p = 0.000457), TY (p = 0.000457) & Lavandula angustifolia (LA; p = 0.0117) on Staphylococcus aureus were statistically different from the control.

   • According to Coccimiglio J (2016)

     Excerpt This study was conducted to identify the major constituents of the ethanolic Origanum vulgare extract & examine the cytotoxic, antioxidant, & antibacterial properties of the extract but more importantly the contribution of its specific major constituent(s) or their combination to the overall extract biological activity. The extract also exhibited antimicrobial properties against Gram-positive & Gram-negative bacterial strains including clinical isolates.

   • According to Khan M (2018)

     Excerpt The essential oil & aqueous distillate composition of Origanum vulgare L. The data suggest that carvacrol, a major component of both oils, possesses the highest antibacterial activity of all the constituents and is the main component responsible for the antibacterial activity of Saudi O.

   • According to Orhan I.E (2012)

     Excerpt The essential oils obtained from Anethum graveolens, Foeniculum vulgare collected at fully-mature & flowering stages, Mentha piperita, Mentha spicata, Lavandula officinalis, Ocimum basilicum (green- & purpleleaf varieties), Origanum onites, O. Most of the tested oils & compounds exhibited good antibacterial & antifungal effects.

2. 2

   Cancer: adjuvant treatment of colorectal and epithelial lung adenocarcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Yıldırım Q (2015)

     Excerpt Other a study the cytotoxicity effect of petroleum ether, ethyl acetate, ethanol, & water of aerials parts of Origanum compactum were investigated on breast carcinoma cell (MCF-7). Sivas & Tomsuk determined cytotoxic & apoptotic effects of essential oil Origanum onites & its phenolic constituent carvacrol on human hepatocellular carcinoma cells (HepG2).

   • According to Mashhadi F (2021)

     Excerpt Results: We found that ethanolic extracts at a concentration of 1 mg/mL significantly increased lymphocyte proliferation (47% by Origanum vulgare & 95% by Origanum majorana compared to the control group). Mashhadi F et al, Immunomodulatory Effects of Origanum vulgare L.

   • According to Grbović F (2013)

     Excerpt In the present investigation, we examined the cytotoxic effect of methanolic extract from Origanum vulgare on HCT-116 & MDA-MB-231 cell line in vitro. Based on the results it is determined that OV is a significant source of biologically active substances that have cytotoxic & antiproliferative activity in vitro.

   • According to Chuang LT (2018)

     Excerpt In this study, we examined the suppressive effect of ethanolic Origanum vulgare extract on live P. acnes & human THP-1 monocytes, EOE reduced the production of interleukin (IL)-8, IL-1_ & tumor necrosis factor (TNF)-_ up to 40%, 37%, & 18%, respectively, as well as the expression of these three proinflammatory mediators at the transcriptional level.

   • According to Koldas S (2015)

     Excerpt vulgare & Origanum acutidens: rosmarinic acid (in highest abundance), chicoric acid, caffeic acid, p-coumaric acid, gallic acid, quercetin, apigenin-7-glucoside, kaempferol, naringenin & 4-hydroxybenzaldehyde. A detailed phytochemical analysis of Origanum vulgare L.

3. 3

   Inflammatory conditions: osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to De Santis F (2019)

     Excerpt Altogether, these results show that HyE-Ov promotes anti-mycobacterial innate immunity & limits inflammatory response in vitro & suggest that this plant extract may be exploitable as phytocomplex or nutraceutical for novel host-directed therapeutic approaches. Results showed that the capability to activate anti-microbial & anti-inflammatory response is shared by different fractions, suggesting that diverse bioactive molecules are present within the hydroalcoholic extract.

   • According to Mazzarello V (2020)

     Excerpt & Origanum vulgare) & tretinoin (MOTC) to evaluate its anti-acne effectiveness and action on the microclimate of the skin. Conclusion: MOTC has shown, compared to Acnatac, to have anti-acne efficacy & to possess an anti-inflammatory activity, due to essential oils, able to reduce in vivo erythematous lesions & those induced by retinoids,.

   • According to Chuang LT (2018)

     Excerpt In this study, we examined the suppressive effect of ethanolic Origanum vulgare extract on live P. acnes-induced inflammatory responses could be due, in part, to the anti-inflammatory.

   • According to Lombrea A (2020)

     Excerpt The antibacterial, antifungal, antiparasitic, antioxidant, anti-inflammatory, antitumor, skin disorders beneficial effects, next to antihyperglycemic & anti-Alzheimer activities were reported & confirmed in multiple studies. The ethnopharmacological uses of Origanum vulgare L.

   • According to Yıldırım Q (2015)

     Excerpt In a work; the anti-proliferative properties of Origanum acutidens (OA) was investigated on breast cancer cell lines MCF-7, MDAMB- 468 & MDA-MB-231. Dhaheri & colleagues studied the anti-metastatic & anti-tumor effect of Origanum majorana.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.