Orthosiphon aristatus (Babin ’chat) : medicinal properties in alcoholic extraction

Orthosiphon aristatus (Babin ’chat, Cat’s whiskers, Java tea, Moustache-à-chat, Thé de java) — family Lamiacées.

Scientific synonyms : Clerodendranthus spicatus (Thunb.) C.Y. Wu, C spicatum Thunb, C stamineus (Benth.) Kud, Ocimum aristatum Blume, O grandiflorum Blume, Orthosiphon stamineus Benth., O spiralis (Lour.) Merr., O velteri Doan, O spicatus (Thunb.) Backer, O tagawae Murat..

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 72 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of colorectal, oral, liver, leukaemia, breast, ovarian and lung cancer, and melanoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Samidurai D (2020)

     Excerpt Orthosiphon aristatus is a traditional folk medicine extensively used in Southeast Asia because of its various pharmacological effects, including antioxidant, antitumor, & hypoglycemic activities. Orthosiphon extracts have been found to be cytotoxic to hepatocellular carcinoma (HCC) cells, which is attributed to their phytochemical content.

   • According to AL-Shehade SA (2023)

     Excerpt Orthosiphon aristatus (Blume) Miq, a traditional plant in South Asia, has previously been shown to attenuate obesity and hyperglycaemic conditions. Liver enzymes including alanine aminotransferase & aspartate transaminase were significantly reduced in treated mice by 74.2% ± 7.69 & 52.8% ± 7.83, respectively.

   • According to Binti Hashi-Mas S, ETHANOL EXTRACT OF ORTHOSIPHON STAMINEUS BENTH EXHIBITS ANTIOBESITY EFFECT BY INHIBITING ANGIOGENESIS AND PANCREATIC LIPASE, Thesis, Univ Sains, Malaysia, 2016.-ABSTRACT

     Excerpt In this study, the Antiobesity effect of Orthosiphon stamineus was investigated using ethanol extract, 50% ethanol-water extract (EW) & water extract (W) of this plant species. Ethanol extract with the most potent antiangiogenic activity showed a significant Antiobesity property in vivo.

   • According to Han CJ (2008)

     Excerpt Han CJ et al, Effect of methanol leaf extract of Orthosiphon stamineus Benth on hepatic drug metabolizing enzymes in Sprague Dawley (SD) rats, J of Biosci, 19(1) :21–3, 2008.

   • According to Alshawsh, M.A (2011)

     Excerpt Alshawsh, M.A et al, Hepatoprotective effects of Orthosiphon stamineus extract on thioacetamide-induced liver cirrhosis in rats.

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mohamed EA (2015)

     Excerpt In streptozotocin-induced diabetic rats, only the group treated with 1000 mg/kg of the extract showed significantly (P < 0.05) lower plasma glucose levels after starch loading. stamineus can be considered as a potential agent for the management of diabetes mellitus.

   • According to Sriplang K (2007)

     Excerpt Sriplang K et al, Effects of Orthosiphon stamineus aqueous extract on plasma glucose concentration & lipid profile in normal & streptozotocin-induced diabetic rats, J of Ethnopharm, 109(3) :510–4, 2007.

   • According to AL-Shehade SA (2023)

     Excerpt Orthosiphon aristatus (Blume) Miq, a traditional plant in South Asia, has previously been shown to attenuate obesity and hyperglycaemic conditions. Furthermore, the treated mice showed a reduction in serum levels of glucose (50% ± 5.71), insulin (70.2% ± 12.09), total cholesterol (27.5% ± 15.93), triglycerides (63.2% ± 16.5), low-density lipoprotein (62.5% ± 4.93) & atherogenic risk index relative to the negative control.

   • According to Shafaei A (2013)

     Excerpt The leaves of the plant have been used for treatment of a wide range of ailments including diabetes, hypertension, gout & cancer.

   • According to Pan Y (2011)

     Excerpt orthosiphon stamineus (OS) has been traditionally used to treat diabetes, kidney & urinary disorders, high blood pressure & bone or muscular pain.

3. 3

   Viremia: herpes simplex type 1 (HSV-1) & vesicular stomatitis virus (VSV)

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Manaf AA (1996)

     Excerpt Antiviral activity was tested against the herpès simplex type-1 (HSV-1) & Vesicular stomatitis (VSV) viruses & cytotoxicity was assayed using the HeLa cell line. Antiviral activity against both viruses was present in the extracts from Costus speciosus, Mentha arvensis-Orthosiphon aristatus.

   • According to Malahubban M (2013)

     Excerpt Leaves of Andrographis paniculata & Orthosiphon stamineus were extracted with water, ethanol, methanol & chloroform to assess their potential as antibacterial & antioxidant agents. These leaf extracts exhibited antimicrobial & antioxidant activities &, at the highest concentration tested (200 mg/mL), showed greater inhibitory effects against the Gram positive bacteria Bacillus cereus & Staphylococcus aureus than 10% acetic acid.

   • According to Ho CH (2010)

     Excerpt Ho CH et al, in vitro antibacterial & antioxidant activities of Orthosiphon stamineus Benth extracts against foodborne bacteria.

   • According to Author (2013)

     Excerpt The present study was undertaken to carry out phytochemical, antimicrobial & anticancer studies on O. The maximum antibacterial activity was found to be in ethyl acetate among 3 extracts.

   • According to Hossain MA (2008)

     Excerpt The hydrodistilled essential leaves & stems oils of Orthosiphon stamineus Benth were analysed by GC–MS/MS.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.