Parkinsonia aculeata (Jerusalem thorn) : medicinal properties in alcoholic extraction

Parkinsonia aculeata (Jerusalem thorn, Épine de Jérusalem) — family Caesalpiniacées.

Scientific synonyms : Parkinsonia inermis Spreng., P spinosa Kunth, P thornberi M.E.Jones.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 35 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Liver disorders: hepatitis, cirrhosis, fatty liver; normalisation of serum parameters: ALT, AST, ALP, serum bilirubin

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Leite ACR (2011)

     Excerpt The diabetic rats treated with HEPA showed a significant reduction in serum & urinary glucose, urinary urea & triglyceride levels, as compared to the diabetic untreated group. However, in the normal treated groups, a significant reduction was found only in serum triglyceride levels.

   • According to Hassan S (2008)

     Excerpt Hepatoprotective activity of 50% ethanolic leaf extracts of Parkinsonia aculeata was evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Significantly (p<0.05) elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TB) & peroxide value in CCl4-intoxicated rats were restored to normal levels in the animals treated with the extract at doses of 100, 200 & 300 mg -1-kg & CCl4.

   • According to Marzouk M (2012)

     Excerpt Five novel macrocyclic monoterpene O-glycosides, parkinsenes A-E (1-5), & eleven known phenolic metabolites including three 3-O-glycosyl-flavonols (6-8), five C-glycosyl-flavones (9-13), p-hydroxybenzoic acid (14), esculetin (15), & diosmetin (16) were isolated from the leaves & small twigs of Parkinsonia aculeata L.

   • According to Gomes-Araujo T (2016)

     Excerpt Aims of the study : In this context, we aimed to use molecular & physiological methods to study the effect of a hydroethanolic extract partitioned with ethyl acetate from the aerial parts of Parkinsonia aculeata(HEPa/EtOAc) on insulin resistance in a mouse model of diet-induced obesity (DIO). Parkinsonia aculeata L.

   • According to Hassan WHB (2018)

     Excerpt Polyphenolic constituents & chromatographic fingerprint of the aqueous fraction obtained from the ethanolic extract of the aerial parts of Parkinsonea aculeata growing in Saudi Arabia were investigated for the first time using UPLC-ESI/MS/MS in negative mode. However, this fraction showed a very weak cytotoxic activity against HepG-2 (Hepatocellular carcinoma) & MCF-7 (Breast carcinoma) with IC50 222 ± 1.8 & 304 ± 9.2 µg/ml respectively compared to cisplatin IC50 3.67 ± 8.1 & 5.71 ± 3.8 µg/ml respectively.

2. 2

   Type II diabetes mellitus

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Franco ES (2022)

     Excerpt Previous studies have described Parkinsonia Aculeata as a product with both hypoglycemic & hypotriglyceridemic effects. The observed evidence may contribute to the control of metabolic parameters as dyslipidemia corroborating the ethnopharmacological information concerning the antihyperlipidemic & hypoglycemic activities of PA.

   • According to Leite ACR (2011)

     Excerpt This paper reports the characterization of the antidiabetic role of a hydroethanolic extract from Parkinsonia aerial parts (HEPA), in normal & alloxan-induced diabetic rats, treated with HEPA (125 & 250 mg/kg; p.o.). aculeata presents an antidiabetic activity & other beneficial effects that ameliorate diabetes & associated complications.

   • According to Gomes-Araujo T (2016)

     Excerpt Aims of the study : In this context, we aimed to use molecular & physiological methods to study the effect of a hydroethanolic extract partitioned with ethyl acetate from the aerial parts of Parkinsonia aculeata(HEPa/EtOAc) on insulin resistance in a mouse model of diet-induced obesity (DIO). Parkinsonia aculeata L.

   • According to Marzouk M (2012)

     Excerpt Five novel macrocyclic monoterpene O-glycosides, parkinsenes A-E (1-5), & eleven known phenolic metabolites including three 3-O-glycosyl-flavonols (6-8), five C-glycosyl-flavones (9-13), p-hydroxybenzoic acid (14), esculetin (15), & diosmetin (16) were isolated from the leaves & small twigs of Parkinsonia aculeata L. The investigated 80 % aqueous methanol extract (AME) showed significant analgesic, antipyretic, anti-inflammatory, hepato-protective, hypoglycemic, hypocholesterolemic, & antioxidant activities in a dose-dependent manner using two different doses 250 & 500 mg/kg b.

   • According to Leite ACR (2007)

     Excerpt Leite ACR et al, Parkinsonia aculeata aqueous extract fraction: Biochemical studies in alloxan-induced diabetic rats.

3. 3

   Cancer: adjuvant treatment for liver and breast cancer

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hassan S (2008)

     Excerpt Hepatoprotective activity of 50% ethanolic leaf extracts of Parkinsonia aculeata was evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Hepatoprotective activity was measured based on biochemical parameters.

   • According to Leite ACR (2011)

     Excerpt This paper reports the characterization of the antidiabetic role of a hydroethanolic extract from Parkinsonia aerial parts (HEPA), in normal & alloxan-induced diabetic rats, treated with HEPA (125 & 250 mg/kg; p.o.). In all treated diabetic groups, an improvement in hepatic glycogen was observed, as well as a decrease in liquid intake & urinary volume, & an enhancement in the weight of skeletal muscles ( soleus & extensor digitorum longus ), kidneys & epididymal adipose tissue.

   • According to Marzouk M (2012)

     Excerpt Five novel macrocyclic monoterpene O-glycosides, parkinsenes A-E (1-5), & eleven known phenolic metabolites including three 3-O-glycosyl-flavonols (6-8), five C-glycosyl-flavones (9-13), p-hydroxybenzoic acid (14), esculetin (15), & diosmetin (16) were isolated from the leaves & small twigs of Parkinsonia aculeata L. The investigated 80 % aqueous methanol extract (AME) showed significant analgesic, antipyretic, anti-inflammatory, hepato-protective, hypoglycemic, hypocholesterolemic, & antioxidant activities in a dose-dependent manner using two different doses 250 & 500 mg/kg b.

   • According to Das P (2022)

     Excerpt In our present study, Synthesized the AuNPs from Aerva javanica & Parkinsonia aculeata extract & studied the p53, caspase-3, Caspase-9 & NF-kB gene expression in HeLa & HepG2 cell lines by Real-time PCR. Based on the present results concluding the AJ AuNPs are effective anti-cancer activity on cervical cancer cells.

   • According to Menezes TM (2021)

     Excerpt The cytotoxicity of PfrHEPA was performed on the tumor lines NCI-H292 (human lung carcinoma), HL-60 (human promyelocytic leukemia) & HCT-116 (colorectal cancer). This study was aimed to evaluate toxicity in repeated doses for 28 days, reproductive toxicity & cytotoxicity of a polar fraction obtained from the hydroethanolic extract of Parkinsonia aculeata (PfrHEPA) in experimental models.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.