Parkinsonia aculeata (Épine de Jérusalem) : vertus médicinales en extraction alcoolique

Parkinsonia aculeata (Épine de Jérusalem, Jerusalem thorn) — famille Caesalpiniacées.

Synonymes scientifiques : Parkinsonia inermis Spreng., P spinosa Kunth, P thornberi M.E.Jones.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 10 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 35 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Troubles hépatiques : hépatite, cirrhose, stéatose hépatique, normalisation des paramètres sériques :ALT, ASP, ALP, Bilirubin émie

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Leite ACR (2011)

     Extrait The diabetic rats treated with HEPA showed a significant reduction in serum & urinary glucose, urinary urea & triglyceride levels, as compared to the diabetic untreated group. However, in the normal treated groups, a significant reduction was found only in serum triglyceride levels.

   • Selon Hassan S (2008)

     Extrait Hepatoprotective activity of 50% ethanolic leaf extracts of Parkinsonia aculeata was evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Significantly (p<0.05) elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TB) & peroxide value in CCl4-intoxicated rats were restored to normal levels in the animals treated with the extract at doses of 100, 200 & 300 mg -1-kg & CCl4.

   • Selon Marzouk M (2012)

     Extrait Five novel macrocyclic monoterpene O-glycosides, parkinsenes A-E (1-5), & eleven known phenolic metabolites including three 3-O-glycosyl-flavonols (6-8), five C-glycosyl-flavones (9-13), p-hydroxybenzoic acid (14), esculetin (15), & diosmetin (16) were isolated from the leaves & small twigs of Parkinsonia aculeata L.

   • Selon Gomes-Araujo T (2016)

     Extrait Aims of the study : In this context, we aimed to use molecular & physiological methods to study the effect of a hydroethanolic extract partitioned with ethyl acetate from the aerial parts of Parkinsonia aculeata(HEPa/EtOAc) on insulin resistance in a mouse model of diet-induced obesity (DIO). Parkinsonia aculeata L.

   • Selon Hassan WHB (2018)

     Extrait Polyphenolic constituents & chromatographic fingerprint of the aqueous fraction obtained from the ethanolic extract of the aerial parts of Parkinsonea aculeata growing in Saudi Arabia were investigated for the first time using UPLC-ESI/MS/MS in negative mode. However, this fraction showed a very weak cytotoxic activity against HepG-2 (Hepatocellular carcinoma) & MCF-7 (Breast carcinoma) with IC50 222 ± 1.8 & 304 ± 9.2 µg/ml respectively compared to cisplatin IC50 3.67 ± 8.1 & 5.71 ± 3.8 µg/ml respectively.

2. 2

   Diabète mellitus de type II

   Partie usitée : Parties aériennes.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Franco ES (2022)

     Extrait Previous studies have described Parkinsonia Aculeata as a product with both hypoglycemic & hypotriglyceridemic effects. The observed evidence may contribute to the control of metabolic parameters as dyslipidemia corroborating the ethnopharmacological information concerning the antihyperlipidemic & hypoglycemic activities of PA.

   • Selon Leite ACR (2011)

     Extrait This paper reports the characterization of the antidiabetic role of a hydroethanolic extract from Parkinsonia aerial parts (HEPA), in normal & alloxan-induced diabetic rats, treated with HEPA (125 & 250 mg/kg; p.o.). aculeata presents an antidiabetic activity & other beneficial effects that ameliorate diabetes & associated complications.

   • Selon Gomes-Araujo T (2016)

     Extrait Aims of the study : In this context, we aimed to use molecular & physiological methods to study the effect of a hydroethanolic extract partitioned with ethyl acetate from the aerial parts of Parkinsonia aculeata(HEPa/EtOAc) on insulin resistance in a mouse model of diet-induced obesity (DIO). Parkinsonia aculeata L.

   • Selon Marzouk M (2012)

     Extrait Five novel macrocyclic monoterpene O-glycosides, parkinsenes A-E (1-5), & eleven known phenolic metabolites including three 3-O-glycosyl-flavonols (6-8), five C-glycosyl-flavones (9-13), p-hydroxybenzoic acid (14), esculetin (15), & diosmetin (16) were isolated from the leaves & small twigs of Parkinsonia aculeata L. The investigated 80 % aqueous methanol extract (AME) showed significant analgesic, antipyretic, anti-inflammatory, hepato-protective, hypoglycemic, hypocholesterolemic, & antioxidant activities in a dose-dependent manner using two different doses 250 & 500 mg/kg b.

   • Selon Leite ACR (2007)

     Extrait Leite ACR et al, Parkinsonia aculeata aqueous extract fraction: Biochemical studies in alloxan-induced diabetic rats.

3. 3

   Cancer : traitement adjuvant du carcinome hépatique & mammaire

   Partie usitée : Parties aériennes.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Hassan S (2008)

     Extrait Hepatoprotective activity of 50% ethanolic leaf extracts of Parkinsonia aculeata was evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Hepatoprotective activity was measured based on biochemical parameters.

   • Selon Leite ACR (2011)

     Extrait This paper reports the characterization of the antidiabetic role of a hydroethanolic extract from Parkinsonia aerial parts (HEPA), in normal & alloxan-induced diabetic rats, treated with HEPA (125 & 250 mg/kg; p.o.). In all treated diabetic groups, an improvement in hepatic glycogen was observed, as well as a decrease in liquid intake & urinary volume, & an enhancement in the weight of skeletal muscles ( soleus & extensor digitorum longus ), kidneys & epididymal adipose tissue.

   • Selon Marzouk M (2012)

     Extrait Five novel macrocyclic monoterpene O-glycosides, parkinsenes A-E (1-5), & eleven known phenolic metabolites including three 3-O-glycosyl-flavonols (6-8), five C-glycosyl-flavones (9-13), p-hydroxybenzoic acid (14), esculetin (15), & diosmetin (16) were isolated from the leaves & small twigs of Parkinsonia aculeata L. The investigated 80 % aqueous methanol extract (AME) showed significant analgesic, antipyretic, anti-inflammatory, hepato-protective, hypoglycemic, hypocholesterolemic, & antioxidant activities in a dose-dependent manner using two different doses 250 & 500 mg/kg b.

   • Selon Das P (2022)

     Extrait In our present study, Synthesized the AuNPs from Aerva javanica & Parkinsonia aculeata extract & studied the p53, caspase-3, Caspase-9 & NF-kB gene expression in HeLa & HepG2 cell lines by Real-time PCR. Based on the present results concluding the AJ AuNPs are effective anti-cancer activity on cervical cancer cells.

   • Selon Menezes TM (2021)

     Extrait The cytotoxicity of PfrHEPA was performed on the tumor lines NCI-H292 (human lung carcinoma), HL-60 (human promyelocytic leukemia) & HCT-116 (colorectal cancer). This study was aimed to evaluate toxicity in repeated doses for 28 days, reproductive toxicity & cytotoxicity of a polar fraction obtained from the hydroethanolic extract of Parkinsonia aculeata (PfrHEPA) in experimental models.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.