Passiflora edulis (Marakoudja) : medicinal properties in alcoholic extraction

Passiflora edulis (Marakoudja, Maracuzza, Passion flower, Fleur de la passion) — family Passifloracées.

Scientific synonyms : Passiflora diadem-Vell., P idocarina-Barb, P pallidiflora-Bert., P rigida-Jacq, P Verrucifera-Lindl.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 59 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Fruit Peel.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Silva DC (2011)

     Excerpt Flour made from Passiflora edulis fruit peel has been used in Brazil to treat diabetes. edulis on rats with alloxan-induced diabetes, on myeloperoxidase release from human neutrophils, & on carrageenan-induced paw edema.

   • According to Martins C (2015)

     Excerpt This study was conducted to evaluate the effects of the ethanolic extract of Passiflora edulis leaves on blood glucose, protein glycation, NADPH oxidase activity & macrophage phagocytic capacity after Candida albicans exposure in diabetic rats. Our results suggest that ethanolic PE leaf extraction may have beneficial effects on diabetes & may improve glycaemic control in diabetic rats,,.

   • According to Guan Y (2021)

     Excerpt One polysaccharide, designated as WPEP-A, was isolated from Passiflora edulis-Sims ‘s peel & its hypoglycemic effects on diabetic db/db mice were evaluated. In summary, our results showed that WPEP-A had hypoglycemic activity &improved intestinal function in diabetic mice, which may contribute to the attenuation of the hypoglycemia effects.

   • According to Soares RDF (2019)

     Excerpt This study aimed to develop a chitosan‐based hydrogel containing a mixture of flavonoids isolated from the leaves of Passiflora edulis & to evaluate its stability, antioxidant properties, & wound healing effects on cutaneous lesions in diabetic rats. In addition, treatment of the wound with the formulation stimulated the antioxidant defense system, suggesting a beneficial effect during the treatment of skin lesions in diabetic rats, especially in the first few days after wounding.

2. 2

   Viremia: herpes simplex virus 1 and 2 (HSV-1, HSV-2), varicella-zoster virus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Jabareen A (2013)

     Excerpt In the present study we examined, in vitro, the antiviral potential of aqueous & ethanolic leaf extracts on herpes simplex viruses 1 & 2 (HSV-1, HSV-2) & on Varicella-Zoster virus (VZV). Most prominent antiviral activity was obtained when the 80%-MeOH fraction was added during the infection, or when it was incubated with the virus particles prior to infection.

   • According to Ripa F (2009)

     Excerpt The petroleum ether & chloroform fractions of ethanol extract of leaf & stem from the plant Passiflora edulis (Fam: Passifloraceae) was subjected to antioxidant, antibacterial & cytotoxic activity. The crude chloroform & petroleum ether extracts of stem showed notable antibacterial activity at a concentration 500 μg/disc ranged from 8-17 & 7-12 respectively against twelve microorganisms However, in the brine shrimp lethality bioassay, all the crude extracts of leaf & stem possessed considerable cytotoxic activity.

   • According to Zhang J (2013)

     Excerpt A new flavonoid glycoside, chrysin 6-C-β-rutinoside (chrysin α-L-rhamnopyranosyl-(1→6)-C-β-glucopyranoside; 2), & two new triterpene glycosides, (31R)-31-O-methylpassiflorine (7) & (31S)-31-O-methylpassiflorine (8), along with 14 known glycosides, including three flavonoid glycosides, 1, 3, & 4, six triterpene glycosides, 5, 6, & 9-12, three cyano glycosides, 13-15, & two other glycosides, 16 & 17, were isolated from a MeOH extract of the leaves of Passiflora edulis (passion flower; Passifloraceae). In addition, compounds 1-17 were evaluated for their inhibitory effects against the EpsteinBarr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells.

3. 3

   Cancer: adjuvant treatment of hormone-dependent and hormone-independent breast cancer

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Aguillón-Osma (2013)

     Excerpt To investigate the antioxidant & antiproliferative activity of ethanolic & aqueous extracts from leaves & fruits of Passiflora edulis. Materials & methods: A preliminary phytochemical screening was performed; antioxidant activity was evaluated through DPPH assay, the scavenging activity for hydroxyl radical, antihaemolytic activity & total phenolic content; cytotoxic & antiproliferative activities were evaluated by MTT & Sulforhodamine B assays respectively in colon adenocarcinoma SW480 cells & their metastatic-derived SW620 cells.

   • According to Silva DC (2011)

     Excerpt Flour made from Passiflora edulis fruit peel has been used in Brazil to treat diabetes. In the experiments on carrageenan-induced paw edema, paws were dissected for hematoxylin-eosin staining and immunohistochemistry determinations of tumor necrosis factor-α and inducible nitric oxide synthase.

   • According to Fotsing S (2023)

     Excerpt Fotsing S et al, Breast cancer cell growth arrest & chemopreventive effects of Passiflora edulis Sims (Passifloraceae) ethanolic leaves extract on a rat model of mammary carcinoma, Pharmacol, 311:116408.2023-Abstrtact: Despite various prevention & treatment measures, the incidence & mortality due to breast cancer has been increasing globally. Conclusion: PE has chemo-preventive effects against DMBA-induced breast cancer in rats probably through its antioxidative, anti-inflammatory & apoptosis-inducing potentials.

   • According to Montanher AB (2007)

     Excerpt The popular medicine Passiflora edulis has been used as a sedative, tranquilizer, against cutaneous inflammatory diseases & intermittent fever. flavicarpa Degener (Passifloraceae) in the mouse model of pleurisy induced by carrageenan (Cg), bradykinin, histamine or substance P, observing the effects upon leucocytes migration, myeloperoxidase (MPO), nitric oxide (NO) concentrations & tumor necrosis factor-alpha (TNFalpha) & interleukin-1 beta (IL-1beta) levels.

   • According to Author (2003)

     Excerpt These results, arrest of the cell cycle, induction of apoptosis & a reduction of cell viability, showed that phytochemicals present in passion fruit may have beneficial anticancer effects.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.