Passiflora edulis (Marakoudja) : vertus médicinales en extraction alcoolique

Passiflora edulis (Marakoudja, Maracuzza, Fleur de la passion, Passion flower) — famille Passifloracées.

Synonymes scientifiques : Passiflora diadem-Vell., P idocarina-Barb, P pallidiflora-Bert., P rigida-Jacq, P Verrucifera-Lindl.

Sources externes reconnues associées à cette monographie : TRAMIL.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 12 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 59 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Pelure de Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Silva DC (2011)

     Extrait edulis on rats with alloxan-induced diabetes, on myeloperoxidase release from human neutrophils, & on carrageenan-induced paw edema. Flour made from Passiflora edulis fruit peel has been used in Brazil to treat diabetes.

   • Selon Martins C (2015)

     Extrait This study was conducted to evaluate the effects of the ethanolic extract of Passiflora edulis leaves on blood glucose, protein glycation, NADPH oxidase activity & macrophage phagocytic capacity after Candida albicans exposure in diabetic rats. Our results suggest that ethanolic PE leaf extraction may have beneficial effects on diabetes & may improve glycaemic control in diabetic rats,,.

   • Selon Guan Y (2021)

     Extrait One polysaccharide, designated as WPEP-A, was isolated from Passiflora edulis-Sims ‘s peel & its hypoglycemic effects on diabetic db/db mice were evaluated. In summary, our results showed that WPEP-A had hypoglycemic activity &improved intestinal function in diabetic mice, which may contribute to the attenuation of the hypoglycemia effects.

   • Selon Soares RDF (2019)

     Extrait This study aimed to develop a chitosan‐based hydrogel containing a mixture of flavonoids isolated from the leaves of Passiflora edulis & to evaluate its stability, antioxidant properties, & wound healing effects on cutaneous lesions in diabetic rats. In addition, treatment of the wound with the formulation stimulated the antioxidant defense system, suggesting a beneficial effect during the treatment of skin lesions in diabetic rats, especially in the first few days after wounding.

2. 2

   Virémie : herpès simplex virus 1 & 2 (HSV-1, HSV-2), Varicella-Zoster virus

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Jabareen A (2013)

     Extrait In the present study we examined, in vitro, the antiviral potential of aqueous & ethanolic leaf extracts on herpes simplex viruses 1 & 2 (HSV-1, HSV-2) & on Varicella-Zoster virus (VZV). Most prominent antiviral activity was obtained when the 80%-MeOH fraction was added during the infection, or when it was incubated with the virus particles prior to infection.

   • Selon Ripa F (2009)

     Extrait The petroleum ether & chloroform fractions of ethanol extract of leaf & stem from the plant Passiflora edulis (Fam: Passifloraceae) was subjected to antioxidant, antibacterial & cytotoxic activity. The crude chloroform & petroleum ether extracts of stem showed notable antibacterial activity at a concentration 500 μg/disc ranged from 8-17 & 7-12 respectively against twelve microorganisms However, in the brine shrimp lethality bioassay, all the crude extracts of leaf & stem possessed considerable cytotoxic activity.

   • Selon Zhang J (2013)

     Extrait A new flavonoid glycoside, chrysin 6-C-β-rutinoside (chrysin α-L-rhamnopyranosyl-(1→6)-C-β-glucopyranoside; 2), & two new triterpene glycosides, (31R)-31-O-methylpassiflorine (7) & (31S)-31-O-methylpassiflorine (8), along with 14 known glycosides, including three flavonoid glycosides, 1, 3, & 4, six triterpene glycosides, 5, 6, & 9-12, three cyano glycosides, 13-15, & two other glycosides, 16 & 17, were isolated from a MeOH extract of the leaves of Passiflora edulis (passion flower; Passifloraceae). In addition, compounds 1-17 were evaluated for their inhibitory effects against the EpsteinBarr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells.

3. 3

   Cancer : traitement adjuvant du carcinome mammaire hormono-dépendant ou non

   Partie usitée : Feuille. Profil pharmacologique documenté : Tamoxifène-like, Letrozole-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Aguillón-Osma (2013)

     Extrait To investigate the antioxidant & antiproliferative activity of ethanolic & aqueous extracts from leaves & fruits of Passiflora edulis. Materials & methods: A preliminary phytochemical screening was performed; antioxidant activity was evaluated through DPPH assay, the scavenging activity for hydroxyl radical, antihaemolytic activity & total phenolic content; cytotoxic & antiproliferative activities were evaluated by MTT & Sulforhodamine B assays respectively in colon adenocarcinoma SW480 cells & their metastatic-derived SW620 cells.

   • Selon Silva DC (2011)

     Extrait Flour made from Passiflora edulis fruit peel has been used in Brazil to treat diabetes. In the experiments on carrageenan-induced paw edema, paws were dissected for hematoxylin-eosin staining and immunohistochemistry determinations of tumor necrosis factor-α and inducible nitric oxide synthase.

   • Selon Fotsing S (2023)

     Extrait Fotsing S et al, Breast cancer cell growth arrest & chemopreventive effects of Passiflora edulis Sims (Passifloraceae) ethanolic leaves extract on a rat model of mammary carcinoma, Pharmacol, 311:116408.2023-Abstrtact: Despite various prevention & treatment measures, the incidence & mortality due to breast cancer has been increasing globally. Conclusion: PE has chemo-preventive effects against DMBA-induced breast cancer in rats probably through its antioxidative, anti-inflammatory & apoptosis-inducing potentials.

   • Selon Montanher AB (2007)

     Extrait The popular medicine Passiflora edulis has been used as a sedative, tranquilizer, against cutaneous inflammatory diseases & intermittent fever. flavicarpa Degener (Passifloraceae) in the mouse model of pleurisy induced by carrageenan (Cg), bradykinin, histamine or substance P, observing the effects upon leucocytes migration, myeloperoxidase (MPO), nitric oxide (NO) concentrations & tumor necrosis factor-alpha (TNFalpha) & interleukin-1 beta (IL-1beta) levels.

   • Selon Auteur (2003)

     Extrait These results, arrest of the cell cycle, induction of apoptosis & a reduction of cell viability, showed that phytochemicals present in passion fruit may have beneficial anticancer effects.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.