Passiflora foetida (Maribouya) : medicinal properties in alcoholic extraction

Passiflora foetida (Maribouya, Pôk-môl, Ponm-dilyenn-Kolan, Poc mou, Vine apple, sticky, Pomme-de-liane, collante) — family Passifloracées.

Scientific synonyms : Dysosmia foetida-(L.)-M. Roemer, Granadilla foetida-(L.)-Gaertner, Passiflora hispida-Cand ex Triana & Planch, Tripsilina foetida-(L.)-Rafinesque..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 18 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 74 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Joseph P (2014)

     Excerpt Investigation of the total phenol content, total flavanoid content, in vitro lipid peroxidation & radical scavenging activities from Passiflora foetida, Extraction from various solvents were used for the estimations. That the highest free radical scavenging activity was found in ethanolic extract of leaf of PF, Consumption of PF will reduce the free radical formation & afford protection against reactive oxygen species produced during diabetes which may be due to the presence of phenol & flavanoid.

   • According to Asir PJ (2014)

     Excerpt Aqueous & ethanolic extracts of Passiflora foetida 200 mg/kg (leaf, unripe (UR) peel, full ripens (FR) peel, seed & root) was administered orally for 14 days. All the animals were sacrificed after 14 days treatment & its effect on blood glucose, Glucose tolerance test (GTT), hepatic marker enzymes such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum marker like urea, creatinine & protein in alloxan induced diabetic rats were examined.

   • According to Birudu RB (2017)

     Excerpt The objective of this study was to evaluate the antidiabetic activity of Passiflora foetida in a model of dextrose -induced experimental diabetes in rats. The effect of ethanol extract of P foetida leaf extract on blood glucose, plasma insulin, creatinine, glycosylated haemoglobin, serum protein, serum enzymes (serum glutamate pyruvate transaminases) serum glutamate oxaloacetate transaminases & alkaline phosphatase) were measured in the diabetic rats.

   • According to Birudu RB (2015)

     Excerpt In our study we used Passiflora foetida aerial parts against antidiabetic activity in rats. The carbohydrate metabolic enzymes were studied & there were elevation levels of carbohydrate metabolizing enzymes when treated with extract when compared with doxorubicin induced diabetic rats.

   • According to Birudu RB (2014)

     Excerpt In present study ethanol extracts of Passiflora foetida leaves were evaluated for antidyslipidemia activity in dextrose induced diabetic rats. foetida were administered at the doses of 100 mg/kg body weight, 250 mg/kg body weight and 500 mg/kg body weight to the dextrose induced diabetic rats.

2. 2

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ramaswamy A (2009)

     Excerpt Hepatoprotective activity of ethanolic extract of fruits of Passiflora foetida was studied against CCl4 induced hepatic injury in albino rats. Pretreatment of ethanolic extract (EPF 200 mg/kg/day, p.o.) significantly (p<0.001) reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin & gamma glutamate transpeptidase (GGTP).

   • According to Song Y. (2018)

     Excerpt The aim of this work was to evaluate the main nutrients and their antioxidant properties of a Chinese wild edible fruit, Passiflora foetida, collected from the ecoregion of Hainan province, China.

   • According to Michel BG (2022)

     Excerpt In this study, we investigate the possible hepatoprotective effect of the aqueous extract of Passiflora foetida (AEPF) using paracetamol-induced liver damage albino rats as animal model. Results showed that in group II, PCM increased significantly the activity of liver enzymes (ALT, AST, & PAL), the serum level of total & direct bilirubin and decreased significantly the serum level of total cholesterol, triglyceride & total protein in rats.

   • According to Bala-Subramaniam A (2010)

     Excerpt Bala-Subramaniam A et al, Anticarcinogenic effect of Passiflora foetida Linn root on the development of liver cancer induced by DEN in rats.

   • According to HAN X (2023)

     Excerpt This study aimed to explore the anti-inflammatory & d gut microbiota modulation potentials of flavonoid-rich fraction (PFF) extracted from Passiflora foetida fruits.

3. 3

   Cancer: adjuvant treatment for breast cancer

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Moongkarndi P (2004)

     Excerpt niruri] whole plant, Passiflora foetida aerial part, Ardisia elliptica fruit, Morinda citrifolia fruit, Aegle marmelos fruit, Heliotropium indicum whole plant, Stephania venosa [Stephania rotunda] bulb a& Thunbergia laurifolia leaf) were tested for antiproliferative activity against SKBR3 human breast adenocarcinoma cell line using MTT assay. However, all the plant extracts showed activity in potential range for further investigation on cancer cells, showed activity in potential range for further investigation on cancer cells.

   • According to Bala-Subramaniam A (2010)

     Excerpt Bala-Subramaniam A et al, Anticarcinogenic effect of Passiflora foetida Linn root on the development of liver cancer induced by DEN in rats.

   • According to SISIN NNT (2017)

     Excerpt This study was conducted to determine the antiproliferative & antioxidant activities of Passiflora foetida leaves methanolic extract (PFME) against MCF-7, MDA- MB-231, HeLa & Hep G2 cancer cell lines, as well as to determine the antiproliferative activity of the major fractions against HeLa cells, & evaluate the compounds present in the PFME & fractions. Antiproliferative activity towards MCF-7 (HTB22TM) & MDA-MB-231 (HTB-26TM) breast cancer cell lines, Hep G2 (HB8065TM) liver cancer cell line, HeLa (CCL-2TM) cervical cancer cell line & L929 (CCL-1TM) normal cell line were observed & compared to Tamoxifen as a positive control.

   • According to HAN X (2023)

     Excerpt This study aimed to explore the anti-inflammatory & d gut microbiota modulation potentials of flavonoid-rich fraction (PFF) extracted from Passiflora foetida fruits. The results showed that PFF markedly reduced the production of nitric oxide (NO), tumor necrosis factor α (TNF-α), & interleukin 6 (IL-6) in LPS-stimulated RAW 264.7 cells.

   • According to Sripathi KS (2023)

     Excerpt Passiflora foetida, commonly known as stinking passion flower has been used as traditional medicine in treating diseases such as throat infection, giddiness, liver disorder, diarrhea, tumor, nervous disorder, anxiety; sleep disorders, skin infections, hysteria & asthma. In addition, PF has been reported to have potential antioxidant, anti-inflammatory, antiepileptic, anti hyperglycemic, cardio protective, anti-diarrheal, & anti- cancer properties.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.