Pedilanthus l (Bw-lèt) : medicinal properties in alcoholic extraction

Pedilanthus l (Bw-lèt, Pantouf, Zandoli, Gwo Zowèy, Milkwood, slipper, Big Ear, Anolis, Bois-à-lait, pantoufle, Grosse oreille) — family Euphorbiacées.

Scientific synonyms : Pedilanthus tithymaloïdes-(L)-Poit, Tithymalus tithymaloides-Croz.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 67 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mehnoor Farheen (2016)

     Excerpt Group III consists of alloxan induced diabetic rats that were given daily sterile solution, ethanolic leaf extract of Pedilanthus tithymaloides (500 mg/kg), Group IV consists of alloxan induced diabetic rats that were given daily sterile solution, ethanolic leaf extract of PT (1000 mg/kg), Group V consists of alloxan induced diabetic rats that were given daily sterile solution & Glibenclamide(5mg/kg) respectively for 21 days by an intragastric tube with free access of food and water. This study assessed the hypoglycaemic & antihyperlipidemic activities of whole ethanolic leaf extract of Pedilanthus tithymaloides in alloxan-induced diabetic albino Wistar rats.

   • According to Farheen M (2016)

     Excerpt Group III consists of alloxan induced diabetic rats that were given daily sterile solution, ethanolic leaf extract of Pedilanthus tithymaloides (500 mg/kg), Group IV consists of alloxan induced diabetic rats that were given daily sterile solution, ethanolic leaf extract of Pedilanthus tithymaloides (1000 mg/kg), Group V consists of alloxan induced diabetic rats that were given daily sterile solution & Glibenclamide(5mg/kg) respectively for 21 days by an instragastric tube with free access of food & water. This study assessed the hypoglycaemic & antihyperlipidemic activities of whole ethanolic leaf extract of Pedilanthus tithymaloides in alloxan-induced diabetic albino Wistar rats.

   • According to Nagda KK (1998)

     Excerpt Further significant reduction in the titre in insulin dependent diabetes mellitus group was shown to occur along with the increased duration of the diabetic condition, reflecting measurable erythrocyte surface alterations. Significantly low titre was observed in the cases with insulin dependent diabetes mellitus, while non-insulin dependent diabetes mellitus cases did not show any significant change.

   • According to SRIVASTAVA R (2019)

     Excerpt steroids, tannins, triterpenes, coumarins & saponins which have been shown to possess anti-diabetic, antioxidant, analgesic, stomachic, hemostatic, anti-microbial, antifungal, anti- helminthic, antimutagenic, anti-tubercular, antimalarial, anti-inflammatory, abortifacient, antivenom, antibiotic, antiseptic, antihemorrhagic, antiviral & antitumor effect & useful for venereal diseases. The significant bioactive principles reported in PT were diterpenoids, triterpene, flavonoids, carotenoids, pedilanthus coumarin A, pedilanthins coumarin B, 5,7-dihydroxy-8-(2-methylbutyryl)-4-phenylcournarin, theraphin C, isodispar B, isodisparinol B & isomesuol.

2. 2

   Bacterial infection: Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to GOMATHI S (2021)

     Excerpt The antimicrobial susceptibility studies were conducted against gram (-) bacteria such as Escherichia coli, Pseudomonas aeruginosa & gram (+) bacteria such as Staphylococcus aureus. Medicinal plants are used to produce new antimicrobial drugs due to increased bacterial resistance of antibiotics.

   • According to Mohammed S (1996)

     Excerpt Thirty-four other plants (Kucing gala, Limau batik, Bertholletia excelsa, Bixa orellana, Caesalpinia pulcherrima, Cerbera odollam (fruits & leaves), Colocasia gigantea, Curcuma domestica, Curcuma manga, Derris eliptica, Elephantopus scaber, Eleusine indica, Eugenia polyantha, Euphorbia hirta, Euphorbia tirucalli, Gardenia florida, Hedyotis auricularia, Hibiscus rosa-sinensis, Juniperus chinensis (three varieties), Lawsonia inermis, Lecythis ollaria, Mentha arvensis, Mimusops elengi, Ocimum sanctum, Phyllanthus niruri, Piper nigrum, Piperomia pellucida, Pedilanthus tithymaloides, Polygonum minus, Spondias dulcis, Solanum nigrum, Tinospora tuberculata) showed selective antifungal activity, while 21 species were inactive,. Mohammed S et al, Antimycotic Screening of 58 Malaysian Plants against Plant Pathogens, Pest Sci, 1996-Abstract; Ethanolic extracts of 58 Malaysian plants belonging to 24 different families were screened for antifungal activity against seven plant pathogens using the filter paper disc diffusion technique.

   • According to Bapat UC (2014)

     Excerpt against Escherichia coli, Proteus vulgaris, Staphylococcus aureus & Bacillus cereus & Trichophyton mentagrophytes & T. Present investigation deals with the evaluation of the antimicrobial activity of extracts of Jatropha gossypifolia Linn., Sapium sebiferum (L.) Roxb., Kirganelia reticulata (Poir) Baill., Phyllanthus fraternus Webster & Pedilanthus tithymaloides (Linn.) Poit.

   • According to Patil SV (2012)

     Excerpt Dose-dependent growth inhibition of bacterial pathogens Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermis, & Micrococcus luteus was observed for J. Among evaluated eight latex-producing plants, four (Jatropha curcas, Jatropha gossypifolia, Pedilanthus tithymaloides, & Euphorbia milii) showed high potential to produce physicochemically distinct, small-sized & bactericidal AgNPs.

   • According to Ojha D (2015)

     Excerpt To extend its utility & to fully exploit its medicinal potential, we have evaluated the in vitro antiviral activity of a methanolic extract of PT leaves & its isolated compounds against Herpes Simplex Virus type 2 (HSV-2). Bioactivity-guided studies revealed that the extract & one of its constituents, luteolin, had potent antiviral activity against wild-type & clinical isolates of HSV-2 (EC50 48.5–52.6 & 22.4–27.5 μg/ml, respectively), with nearly complete inhibition at 86.5–101.8 & 40.2–49.6 μg/ml, respectively.

3. 3

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Abreu P (2006)

     Excerpt Pertaining to the anti-inflammatory activity, the intraperitoneal administration of the tincture inhibited carrageenan-induced rat paw oedema, whereas in the scavenging assays the tincture showed to be effective against all the assayed ROS & RNS, specially for HO* (IC50 = 345+/-77 microg/mL), O2*- (IC50 = 143+/-7 microg/mL), HOCl (IC50 = 113+/-20 microg/mL), ONOO- (IC50 = 44+/-3 microg/mL), & *NO (IC50 = 54+/-4 microg/mL), but displayed weak activity in the DPPH* assay. In the present study, a tincture from PT collected in Cuba was evaluated for its in vivo anti-inflammatory activity, using the rat paw oedema assay, & for its in vitro scavenging effects on reactive oxygen species (ROS) (HO*, O2*-, HOCl, ROO* & H2O2), reactive nitrogen species (RNS) (ONOO- & *NO), and DPPH* radical.

   • According to ADHIKARY S (2013)

     Excerpt The anti-inflammatory activity of different extracts such as hexane extract (HEPT), methylene chloride extract (MCEPT), chloroform extract (CEPT), ethyl acetate extract (EAEPT) & methanol extract (MEPT) of PT leaves were studied in male albino rats using the carrageenin induced paw edema model with the help of Plethysmometer. Among the different extracts, MTOH extract (MEPT) at the dose of 200 mg/kg body weight showed significantly more anti-inflammatory activity (percentage inhibition 81.44%) in comparison with other extracts using the carrageenin induced paw edema model as compared to the standard drug, Phenylbutazone with percentage inhibition of 82.72%.

   • According to Ghosh S (2019)

     Excerpt The results revealed significant antiinflammatory activity of CE & ME in carrageenan-induced paw edema (acute), vas-cular permeability & cotton pellet granuloma (chronic) models. Pedilanthus tithymaloides (PT) leaves are widely used in Indian medicine to treat inflammation & pain, but until recently no systematic study of these activities was reported.

   • According to Ghosh S (2013)

     Excerpt The results revealed significant antiinflammatory activity of CE & ME in carrageenan-induced paw edema (acute), vas- cular permeability & cotton pellet granuloma (chronic) models. Pedilanthus tithymaloides (PT) leaves are widely used in Indian medicine to treat inflammation & pain, but until recently no systematic study of these activities were reported.

   • According to Dhar SN (1988)

     Excerpt Dhar SN et al, Oral anti-inflammatory activity of pedilanthain: a new proteolytic enzyme from pedilanthus tithymaloides Poit.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.