Pedilanthus l (Bw-lèt) : vertus médicinales en extraction alcoolique

Pedilanthus l (Bw-lèt, Pantouf, Zandoli, Gwo Zowèy, Bois-à-lait, pantoufle, Grosse oreille, Anolis, Milkwood, slipper, Big Ear) — famille Euphorbiacées.

Synonymes scientifiques : Pedilanthus tithymaloïdes-(L)-Poit, Tithymalus tithymaloides-Croz.

Sources externes reconnues associées à cette monographie : TRAMIL.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 7 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 67 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Feuille. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Mehnoor Farheen (2016)

     Extrait Group III consists of alloxan induced diabetic rats that were given daily sterile solution, ethanolic leaf extract of Pedilanthus tithymaloides (500 mg/kg), Group IV consists of alloxan induced diabetic rats that were given daily sterile solution, ethanolic leaf extract of PT (1000 mg/kg), Group V consists of alloxan induced diabetic rats that were given daily sterile solution & Glibenclamide(5mg/kg) respectively for 21 days by an intragastric tube with free access of food and water. This study assessed the hypoglycaemic & antihyperlipidemic activities of whole ethanolic leaf extract of Pedilanthus tithymaloides in alloxan-induced diabetic albino Wistar rats.

   • Selon Farheen M (2016)

     Extrait Group III consists of alloxan induced diabetic rats that were given daily sterile solution, ethanolic leaf extract of Pedilanthus tithymaloides (500 mg/kg), Group IV consists of alloxan induced diabetic rats that were given daily sterile solution, ethanolic leaf extract of Pedilanthus tithymaloides (1000 mg/kg), Group V consists of alloxan induced diabetic rats that were given daily sterile solution & Glibenclamide(5mg/kg) respectively for 21 days by an instragastric tube with free access of food & water. This study assessed the hypoglycaemic & antihyperlipidemic activities of whole ethanolic leaf extract of Pedilanthus tithymaloides in alloxan-induced diabetic albino Wistar rats.

   • Selon Nagda KK (1998)

     Extrait Further significant reduction in the titre in insulin dependent diabetes mellitus group was shown to occur along with the increased duration of the diabetic condition, reflecting measurable erythrocyte surface alterations. Significantly low titre was observed in the cases with insulin dependent diabetes mellitus, while non-insulin dependent diabetes mellitus cases did not show any significant change.

   • Selon SRIVASTAVA R (2019)

     Extrait steroids, tannins, triterpenes, coumarins & saponins which have been shown to possess anti-diabetic, antioxidant, analgesic, stomachic, hemostatic, anti-microbial, antifungal, anti- helminthic, antimutagenic, anti-tubercular, antimalarial, anti-inflammatory, abortifacient, antivenom, antibiotic, antiseptic, antihemorrhagic, antiviral & antitumor effect & useful for venereal diseases. The significant bioactive principles reported in PT were diterpenoids, triterpene, flavonoids, carotenoids, pedilanthus coumarin A, pedilanthins coumarin B, 5,7-dihydroxy-8-(2-methylbutyryl)-4-phenylcournarin, theraphin C, isodispar B, isodisparinol B & isomesuol.

2. 2

   Infection bacterienne : Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon GOMATHI S (2021)

     Extrait The antimicrobial susceptibility studies were conducted against gram (-) bacteria such as Escherichia coli, Pseudomonas aeruginosa & gram (+) bacteria such as Staphylococcus aureus. Medicinal plants are used to produce new antimicrobial drugs due to increased bacterial resistance of antibiotics.

   • Selon Mohammed S (1996)

     Extrait Thirty-four other plants (Kucing gala, Limau batik, Bertholletia excelsa, Bixa orellana, Caesalpinia pulcherrima, Cerbera odollam (fruits & leaves), Colocasia gigantea, Curcuma domestica, Curcuma manga, Derris eliptica, Elephantopus scaber, Eleusine indica, Eugenia polyantha, Euphorbia hirta, Euphorbia tirucalli, Gardenia florida, Hedyotis auricularia, Hibiscus rosa-sinensis, Juniperus chinensis (three varieties), Lawsonia inermis, Lecythis ollaria, Mentha arvensis, Mimusops elengi, Ocimum sanctum, Phyllanthus niruri, Piper nigrum, Piperomia pellucida, Pedilanthus tithymaloides, Polygonum minus, Spondias dulcis, Solanum nigrum, Tinospora tuberculata) showed selective antifungal activity, while 21 species were inactive,. Mohammed S et al, Antimycotic Screening of 58 Malaysian Plants against Plant Pathogens, Pest Sci, 1996-Abstract; Ethanolic extracts of 58 Malaysian plants belonging to 24 different families were screened for antifungal activity against seven plant pathogens using the filter paper disc diffusion technique.

   • Selon Bapat UC (2014)

     Extrait against Escherichia coli, Proteus vulgaris, Staphylococcus aureus & Bacillus cereus & Trichophyton mentagrophytes & T. Present investigation deals with the evaluation of the antimicrobial activity of extracts of Jatropha gossypifolia Linn., Sapium sebiferum (L.) Roxb., Kirganelia reticulata (Poir) Baill., Phyllanthus fraternus Webster & Pedilanthus tithymaloides (Linn.) Poit.

   • Selon Patil SV (2012)

     Extrait Dose-dependent growth inhibition of bacterial pathogens Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermis, & Micrococcus luteus was observed for J. Among evaluated eight latex-producing plants, four (Jatropha curcas, Jatropha gossypifolia, Pedilanthus tithymaloides, & Euphorbia milii) showed high potential to produce physicochemically distinct, small-sized & bactericidal AgNPs.

   • Selon Ojha D (2015)

     Extrait To extend its utility & to fully exploit its medicinal potential, we have evaluated the in vitro antiviral activity of a methanolic extract of PT leaves & its isolated compounds against Herpes Simplex Virus type 2 (HSV-2). Bioactivity-guided studies revealed that the extract & one of its constituents, luteolin, had potent antiviral activity against wild-type & clinical isolates of HSV-2 (EC50 48.5–52.6 & 22.4–27.5 μg/ml, respectively), with nearly complete inhibition at 86.5–101.8 & 40.2–49.6 μg/ml, respectively.

3. 3

   Arthrose, arthrite, rhumatisme, oedème

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Abreu P (2006)

     Extrait Pertaining to the anti-inflammatory activity, the intraperitoneal administration of the tincture inhibited carrageenan-induced rat paw oedema, whereas in the scavenging assays the tincture showed to be effective against all the assayed ROS & RNS, specially for HO* (IC50 = 345+/-77 microg/mL), O2*- (IC50 = 143+/-7 microg/mL), HOCl (IC50 = 113+/-20 microg/mL), ONOO- (IC50 = 44+/-3 microg/mL), & *NO (IC50 = 54+/-4 microg/mL), but displayed weak activity in the DPPH* assay. In the present study, a tincture from PT collected in Cuba was evaluated for its in vivo anti-inflammatory activity, using the rat paw oedema assay, & for its in vitro scavenging effects on reactive oxygen species (ROS) (HO*, O2*-, HOCl, ROO* & H2O2), reactive nitrogen species (RNS) (ONOO- & *NO), and DPPH* radical.

   • Selon ADHIKARY S (2013)

     Extrait The anti-inflammatory activity of different extracts such as hexane extract (HEPT), methylene chloride extract (MCEPT), chloroform extract (CEPT), ethyl acetate extract (EAEPT) & methanol extract (MEPT) of PT leaves were studied in male albino rats using the carrageenin induced paw edema model with the help of Plethysmometer. Among the different extracts, MTOH extract (MEPT) at the dose of 200 mg/kg body weight showed significantly more anti-inflammatory activity (percentage inhibition 81.44%) in comparison with other extracts using the carrageenin induced paw edema model as compared to the standard drug, Phenylbutazone with percentage inhibition of 82.72%.

   • Selon Ghosh S (2019)

     Extrait The results revealed significant antiinflammatory activity of CE & ME in carrageenan-induced paw edema (acute), vas-cular permeability & cotton pellet granuloma (chronic) models. Pedilanthus tithymaloides (PT) leaves are widely used in Indian medicine to treat inflammation & pain, but until recently no systematic study of these activities was reported.

   • Selon Ghosh S (2013)

     Extrait The results revealed significant antiinflammatory activity of CE & ME in carrageenan-induced paw edema (acute), vas- cular permeability & cotton pellet granuloma (chronic) models. Pedilanthus tithymaloides (PT) leaves are widely used in Indian medicine to treat inflammation & pain, but until recently no systematic study of these activities were reported.

   • Selon Dhar SN (1988)

     Extrait Dhar SN et al, Oral anti-inflammatory activity of pedilanthain: a new proteolytic enzyme from pedilanthus tithymaloides Poit.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.