Persea americana (Zaboka) : medicinal properties in alcoholic extraction

Persea americana (Zaboka, Lawyer, Avocat) — family Lauracées.

Scientific synonyms : Laurus persea-L, Persea gratissima var. oblonga-Meisn, P paucitriplinervia-Lindell, P steyermarkii-C.K.A.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 22 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 72 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ochoa-Zarzosa A (2021)

     Excerpt Avocado (Persea americana Mill.) is a tree native from central & eastern México that belongs to the Lauraceae family. Besides, this fruit possesses a high content of carotenoids & phenolic compounds with possible antifungal, anti-cancer & antioxidant activities.

   • According to Mvondo MA (2021)

     Excerpt The ethanol extract of Persea americana seeds was found exhibiting antiproliferative properties in vitro. In conclusion, the ethanol extract of PA seeds could be a complementary treatment to prevent tamoxifen-induced endometrial hyperplasia during the treatment of ER+ breast cancer,.

   • According to D’Ambrosio SM (2011)

     Excerpt Persea americana fruits are consumed as part of the human diet & extracts have shown growth inhibitory effects in various types of human cancer cells, although the effectiveness of individual components & their underlying mechanism are poorly understood. The present data suggest that the potential anticancer activity of avocado fruits is due to a combination of specific aliphatic acetogenins that target two key components of the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway.

   • According to Hamouda AF (2016)

     Excerpt The effect of AVOE (avocado), GE (Ginger) & CE (Cabbage) extracts separately on liver NO (nitric oxide), MDA (malondialdehyde), as well as serum AST (aspartate aminotransferase), ALT (alanine aminotransferase), total bilirubin, TC (total cholesterol), T.G (triglyceride), HDL cholesterol (high-density lipoprotein), LDL cholesterol (low-density lipoprotein), TSH (thyroid-stimulating hormone), T3 (Triiodothyronine), T4 (Thyroxine) in rats treated & untreated with CCl4 (carbon tetrachloride) was studied. Avocado, Cabbage, & Ginger are a part of a regular human diet & have antioxidant, & antitumor effects.

   • According to Padmanabhan M (2013)

     Excerpt The aim of the present study was to evaluate the hypolipidemic & antiatherogenic effect of Persea americana (Avocado) fruit extract on the level of tissue and blood lipids & adiponectin in the adipocytes of rats subjected to experimental hyperlipidemia and atherogenesis. americana was found to reduce the risk of hyperlipidemia probably by elevating the level of adiponectin & also by reducing the level of LDL-C.

2. 2

   Type 2 diabetes mellitus

   Plant part used: Seed. Mentioned synergistic association: Zea mays-stigmate.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Okon AJ (2018)

     Excerpt The effect of ethanolic extracts of Persea americana seed & Zea mays silk on blood glucose levels, body & organ weights of alloxan- induced hyperglycemic Wistar rats was investigated using standard analytical techniques. At the end of the experiment, the groups administered 400 mg/kg body weight Zea mays silk single extract & 400 mg/kg body weight combined extract of P americana seed Z mays silk showed significant (P< 0.05) decrease in fasting blood glucose when compared with the diabetic control.

   • According to OJO AO (2019)

     Excerpt An aqueous extract of Persea americana seeds (AEPAS) was explored in this study as a possible therapeutic agent in rats with diabetes mellitus. The diabetic control group exhibited pancreatic dysfunction as evidenced by a reduction in serum insulin, HOMA-β, expressions of PI3K/AKT, Bcl-2, & PCNA combined with an elevation in HOMA-IR.

   • According to Ozegbe-Evita J (2021)

     Excerpt Ozegbe-Evita J et al, Comparative effects of Carica Papaya, Avocado Pear & Ginger Extracts on the Histological Structure of the Pancreas of Streptozotocin-induced Diabetic Rats, Research-Gate, 2021-Abstractt: he increasing global prevalence of diabetes mellitus requires a holistic approach for its management. This study was carried out to compare the effects of Carica papaya leaves, Persea americana & Zingiber officinale on the histological structure of the pancreas of Streptozotocin (STZ)-induced diabetic Wistar rats.

   • According to Agunloye MO (2025)

     Excerpt Methods: A comprehensive review of relevant published literature was conducted using keywords such as ("avocado plant" or "Persea americana") & ("diabetes"). This review explores the therapeutic potential of Persea americana Mill plant (avocado) in diabetes management & its potential targets.

   • According to Elya B (2015)

     Excerpt These extracts are Camélia sinensis (white, green, fermented), Pometia pinnata, Syzygium polyanthum, Artocarpus heterophyllus, Lagerstroemia speciosa & Persea Americana.

3. 3

   Joint pain, arthritis, osteoarthritis, rheumatism

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Adeyemi OO (2002)

     Excerpt The aqueous extract of Persea americana leaves produced a dose-dependent inhibition of both phases of formalin pain test in mice, a reduction in mouse writhing induced by acetic acid & an elevation of pain threshold in the hot plate test in mice. The results obtained indicate that the extract possesses analgesic & anti-inflammatory effects.

   • According to Ovalle-Marin A (2020)

     Excerpt Furthermore, we report that hydroalcoholic leaves extract presented greater in vitro anti-inflammatory effect, especially the leave hydroalcoholic regarding NO release (p<0.001, against LPS treatment), aqueous & hydroalcoholics regarding TNF- release (p<0.05), & only the hydroalcoholic in the TNF- gene expression (p<0.01). In conclusion, the PA hydroalcoholic extracts, & especially from leaves, present in vitro anti-inflammatory features that might be considered for human health improvement applications.

   • According to De Oliveira A.P (2013)

     Excerpt Anti-inflammatory activity, increase in density of collagen, & tensile strength were observed in SSFAO 50% or PA oil groups, when compared to control groups. When used in natura or in pharmaceutical formulations for topical use, PA oil can promote increased collagen synthesis & decreased numbers of inflammatory cells during the wound-healing process & may thus be considered a new option for treating skin wounds,.

   • According to HONG JY (2019)

     Excerpt Taken together, our data indicate that ethanol extract of PA may be used as a promising therapeutic against inflammatory bowel diseases by suppressing the NF-κB & STAT3 signaling pathway,. In this study, we investigated anti-colitic effects of ethanol extract of PA (EEP) in dextran sulfate sodium (DSS)-induced colitic mice & the involved molecular mechanisms.

   • According to Agunloye MO (2025)

     Excerpt Methods: A comprehensive review of relevant published literature was conducted using keywords such as ("avocado plant" or "Persea americana") & ("diabetes"). This review explores the therapeutic potential of Persea americana Mill plant (avocado) in diabetes management & its potential targets.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.