Petiveria alliacea (Arada) : medicinal properties in alcoholic extraction

Petiveria alliacea (Arada, Douvan-nèg, Zèb-simitjè, Devant-de-nègre, Herbe-à-cimetière) — family Phytolaccacées.

Scientific synonyms : Petiveria foetida-Salisb., P hexandra-S. & M., P octandra-L, P paraguayaensis-Parodi.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 139 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mustika A (2017)

     Excerpt Mustika A et al, Effect of Petiveria alliacea Leaves Extract in Decreasing Serum Level of Blood Glucose Level Through Activation of AMPK-α1 in Diabetes Mellitus Rat Models, J KK Indonesia, 6(3) ! The conclusion of this study was the extract ethanol of Singawalang leaves reduce blood glucose level in diabetes mellitus rat models through increase in the expression of AMPK-α1Singawalang (Petiveria alliaceae) is a medicinal herb that is used traditionally as folk medicine for various diseases.

   • According to Susilawati (2017)

     Excerpt One of the plants that has antidiabetic effect is the leaves of singawalang (Petiveria alliacea. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia.

   • According to Domínguez D (2002)

     Excerpt The effect of a hypoglycemic extract of Petiveria alliacea L on glucose consumption was studied by using the erythrocytes of voluntary healthy donors. That's why its hypoglycemic action seems to be connected with insulin action.

   • According to Rojo D (2000)

     Excerpt Effect of a hypoglycaemic extract of Petiveria alliacea L.

   • According to Lores R (1990)

     Excerpt Petiveria alliacea L.

2. 2

   Cancer: adjuvant treatment for oral carcinoma, breast cancer and leukaemia

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to HERNANDEZ JF (2017)

     Excerpt In American traditional medicine Petiveria alliacea Phytolaccaceae, leaf extracts have been used for leukemia & breast cancer treatments. alliacea extract in tumor/non-tumorigenic cell lines and murine breast cancer model.

   • According to Ruffa MJ (2002)

     Excerpt Methanolic extracts from Achyrocline satureioides, Aristolochia macroura Gómez, Lithraea molleoide, Schinus molle, unlike those from Celtis spinosa Spreng, Chenopodium ambrosioides, Petiveria alliacea & Plantago major. showed cytotoxic activity against a human hepatocellular carcinoma cell line, Hep G2.

   • According to Urueña C (2008)

     Excerpt There is ethnopharmacological evidence that Petiveria alliacea can have antitumor activity; however, the mechanism of its cytotoxic activity is not well understood. Further studies in animal models are needed but P alliacea appears to be a good candidate to be used as an antitumor agent.

   • According to Gomez SF (n.d.)

     Excerpt Additionally, is part of the invention the use of said fraction in drug product manufacture for treating cancer & a treatment kit comprising a pharmaceutical composition containing the bioactive fraction of P alliacea & at least one or more pharmaceutically acceptable excipients, a composition containing one or more immunostimulant agents that can produce the phenotypic &/or functional maturation of the dendritic cells & at least one or more pharmaceutically acceptable excipients and optionally instructions for use, Finally, the invention describes a method for treating cancer comprising sequential administration of an effective therapeutically amount of the bioactive fraction of P alliacea or the composition containing same & in a time between 24 hours & 2 weeks, administration of an effective therapeutically amount of at least one immunostimulant agent that can produce the phenotypic &/or functional maturation of the dendritic cells. In a third objective, the invention describes a pharmaceutical combination for treating cancer, comprising the bioactive fraction of P alliacea or a pharmaceutical composition containing same and at least one immunostimulant agent that can produce the phenotypic and/or functional maturation of the dendritic cells.

   • According to Silva JP (2018)

     Excerpt alliacea also showed cytotoxicity and antiproliferative activity against cancer cell lines through sophisticated machinery of cellular damage in vitro. Petiveria alliacea is a perennial Amazonian shrub used in traditional medicine for many purposes worldwide, including as antirheumatic, antispasmodic, antifungal & analgesic for pain relief.

3. 3

   Infections caused by resistant bacteria: MRSA (Methicillin-resistant Staphylococcus aureus), MRCNS (Methicillin-resistant coagulase-negative staphylococci), VRE (Vancomycin-resistant Enterococcus)

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mulyani Y (2011)

     Excerpt Ethanol extract of dried leaves showed activity against bacteria i.e., MRSA (Methicillin-Resistant Staphylococcus aureus), MRCNS (Methicillin-Resistant Coagulase-Negative Staphylococci). Further studies conducted by reviewing the type of work by looking at the growth curve and the observed changes in cell walls by scanning electron microscopy (SEM) at MRCNS (Methicillin-Resistant Staphylococcus Coagulase-Negative).

   • According to Illnait-Zaragozí1 M (2014)

     Excerpt The aim of the present work it was to evaluate the in vitro antifungal activity of crude hydro-alcoholic extract of Petiveria alliacea L (HAEPAL) versus fluconazole against Candida isolates. Conclusion: These results show the antifungal potentiality of HAEPAL, which could become a potential alternative for Candida treatment.

   • According to Benevides PJ (2001)

     Excerpt Benevides PJ et al, Antifungal polysulphides from Petiveria alliacea L.

   • According to Pacheco A (2013)

     Excerpt In vitro antimicrobial activity of total extracts of the leaves of Petiveria alliacea L.

   • According to Kim S (2006)

     Excerpt Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria alliacea L.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.