Petiveria alliacea (Arada) : vertus médicinales en extraction alcoolique

Petiveria alliacea (Arada, Douvan-nèg, Zèb-simitjè, Devant-de-nègre, Herbe-à-cimetière) — famille Phytolaccacées.

Synonymes scientifiques : Petiveria foetida-Salisb., P hexandra-S. & M., P octandra-L, P paraguayaensis-Parodi.

Sources externes reconnues associées à cette monographie : TRAMIL et Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 12 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 139 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Feuille. Profil pharmacologique documenté : Acarbose-like, Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Mustika A (2017)

     Extrait Mustika A et al, Effect of Petiveria alliacea Leaves Extract in Decreasing Serum Level of Blood Glucose Level Through Activation of AMPK-α1 in Diabetes Mellitus Rat Models, J KK Indonesia, 6(3) ! The conclusion of this study was the extract ethanol of Singawalang leaves reduce blood glucose level in diabetes mellitus rat models through increase in the expression of AMPK-α1Singawalang (Petiveria alliaceae) is a medicinal herb that is used traditionally as folk medicine for various diseases.

   • Selon Susilawati (2017)

     Extrait One of the plants that has antidiabetic effect is the leaves of singawalang (Petiveria alliacea. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia.

   • Selon Domínguez D (2002)

     Extrait The effect of a hypoglycemic extract of Petiveria alliacea L on glucose consumption was studied by using the erythrocytes of voluntary healthy donors. That's why its hypoglycemic action seems to be connected with insulin action.

   • Selon Rojo D (2000)

     Extrait Effect of a hypoglycaemic extract of Petiveria alliacea L.

   • Selon Lores R (1990)

     Extrait Petiveria alliacea L.

2. 2

   Cancer : traitement adjuvant du carcinome buccal, mammaire, de la leucémie

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon HERNANDEZ JF (2017)

     Extrait In American traditional medicine Petiveria alliacea Phytolaccaceae, leaf extracts have been used for leukemia & breast cancer treatments. alliacea extract in tumor/non-tumorigenic cell lines and murine breast cancer model.

   • Selon Ruffa MJ (2002)

     Extrait Methanolic extracts from Achyrocline satureioides, Aristolochia macroura Gómez, Lithraea molleoide, Schinus molle, unlike those from Celtis spinosa Spreng, Chenopodium ambrosioides, Petiveria alliacea & Plantago major. showed cytotoxic activity against a human hepatocellular carcinoma cell line, Hep G2.

   • Selon Urueña C (2008)

     Extrait There is ethnopharmacological evidence that Petiveria alliacea can have antitumor activity; however, the mechanism of its cytotoxic activity is not well understood. Further studies in animal models are needed but P alliacea appears to be a good candidate to be used as an antitumor agent.

   • Selon Gomez SF (s.d.)

     Extrait Additionally, is part of the invention the use of said fraction in drug product manufacture for treating cancer & a treatment kit comprising a pharmaceutical composition containing the bioactive fraction of P alliacea & at least one or more pharmaceutically acceptable excipients, a composition containing one or more immunostimulant agents that can produce the phenotypic &/or functional maturation of the dendritic cells & at least one or more pharmaceutically acceptable excipients and optionally instructions for use, Finally, the invention describes a method for treating cancer comprising sequential administration of an effective therapeutically amount of the bioactive fraction of P alliacea or the composition containing same & in a time between 24 hours & 2 weeks, administration of an effective therapeutically amount of at least one immunostimulant agent that can produce the phenotypic &/or functional maturation of the dendritic cells. In a third objective, the invention describes a pharmaceutical combination for treating cancer, comprising the bioactive fraction of P alliacea or a pharmaceutical composition containing same and at least one immunostimulant agent that can produce the phenotypic and/or functional maturation of the dendritic cells.

   • Selon Silva JP (2018)

     Extrait alliacea also showed cytotoxicity and antiproliferative activity against cancer cell lines through sophisticated machinery of cellular damage in vitro. Petiveria alliacea is a perennial Amazonian shrub used in traditional medicine for many purposes worldwide, including as antirheumatic, antispasmodic, antifungal & analgesic for pain relief.

3. 3

   Infection bactéries résistantes: MRSA (Methicillin-Resistant Staphylococcus aureus), MRCNS (Methicillin-Resistant Coagulase-Negative Staphylococci), VRE (Vancomycin Résistante Enterococcus)

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Mulyani Y (2011)

     Extrait Ethanol extract of dried leaves showed activity against bacteria i.e., MRSA (Methicillin-Resistant Staphylococcus aureus), MRCNS (Methicillin-Resistant Coagulase-Negative Staphylococci). Further studies conducted by reviewing the type of work by looking at the growth curve and the observed changes in cell walls by scanning electron microscopy (SEM) at MRCNS (Methicillin-Resistant Staphylococcus Coagulase-Negative).

   • Selon Illnait-Zaragozí1 M (2014)

     Extrait The aim of the present work it was to evaluate the in vitro antifungal activity of crude hydro-alcoholic extract of Petiveria alliacea L (HAEPAL) versus fluconazole against Candida isolates. Conclusion: These results show the antifungal potentiality of HAEPAL, which could become a potential alternative for Candida treatment.

   • Selon Benevides PJ (2001)

     Extrait Benevides PJ et al, Antifungal polysulphides from Petiveria alliacea L.

   • Selon Pacheco A (2013)

     Extrait In vitro antimicrobial activity of total extracts of the leaves of Petiveria alliacea L.

   • Selon Kim S (2006)

     Extrait Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria alliacea L.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.