Phaseolus vulgaris (Pwa-tann’) : medicinal properties in alcoholic extraction

Phaseolus vulgaris (Pwa-tann’, Pwa wouj, Tender peas, Red peas, Pois tendre, Pois rouge) — family Fabacées.

Scientific synonyms : Phaseolus esculentus-Salisb, P marus-L, P vulgaris-Bur.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 9 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 110 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of colorectal, liver, hormone-dependent breast and prostate cancer

   Plant part used: Fruit peel.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Guajardo-Flores D (2013)

     Excerpt This research evaluated the effect of germination of Phaseolus vulgaris on the antioxidant capacity & antiproliferative activity against cancer cell lines of saponins & flavonoids extracted from seed coats, cotyledons & sprouts. Genistein was related with the activity against mammary cancer cells but flavonols & group B saponins were more related with hepatic & colon cancers.

   • According to Henningson A (2001)

     Excerpt Henningson A et al, Content of short-Chain fatty acids in the hindgut of rats Fed processed Bean (Phaseolus vulgaris) flours varying in distribution & content of indigestible carbohydrates, British J of Nutr, 2001; 86: 379-89.

   • According to Finetti F (2020)

     Excerpt Fagiola di Venâncio water extract is rich in proteins, sugars & polyphenols & displays antioxidant, anti-inflammatory & antiproliferative activities in in vitro assays on colon cancer cellular models. Phaseolus vulgaris L.

   • According to Bernardi C (2023)

     Excerpt Phaseolus vulgaris L. Using HT29 & HCT116 colon cancer cell lines, we showed that the extract obtained after gastrointestinal digestion of cooked beans (the bioaccessible fraction, BF) induces cell death through the induction of the autophagic process.

   • According to Donoso-Quezada J (2020)

     Excerpt Here we loaded saponins & flavonoids obtained from a black bean extract (Phaseolus vulgaris L.) with antiproliferative activity into exosomes extracted from different cell lines to induce an enhanced response in vitro.

2. 2

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Anggraini DR (2018)

     Excerpt Alloxan (120 mg/kg, intraperitoneally)- induced diabetic rats were divided into 5 groups (n=5), i.e., NC: Normal control, P1: Diabetic-control, P2, P3, & P4 (200 mg/kg, 400 mg/kg, & 600 mg/kg of EEPV, orally) for 28 days. Malondialdehyde (MDA) is an important marker of oxidative stress that have correlation with Type 2 diabetes mellitus (DM) progression.

   • According to Sinaga APF (2017)

     Excerpt Alloxan tetrahydro mice causes free radicals & higher reactive oxidative species (ROS) production, being able to lead to reduce insulin secretion from SDQFUHDWLF Ã FHOOV DQG receptor sensitivity in insulin-receptor cells resulting in hyperglycemia conditions.

   • According to Kyznetsova YM (2015)

     Excerpt The social significance of diabetes mellitus lies in the fact that in addition to significant prevalence, this disease is associated with many complications. besides its pronounced hypoglycemic action also has a positive influence on the liver & kidney function markers in STZ-treated diabetic rats.

   • According to Venkateswaran S (2002)

     Excerpt The antioxidant effect of an aqueous extract of Phaseolus vulgaris pods, an indigenous plant used in Ayurvedic medicine in India, was studied in rats with streptozotocin-induced diabetes. The extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase & glutathione-S-transferase in the liver & kidneys of rats with streptozotocin-induced diabetes.

   • According to Almualgel MF (2017)

     Excerpt The present investigation was carried out to evaluate the reduction potential of aqueous extract of casing of pods of Phaseolus vulgaris in blood glucose & lipids levels among hyperglycemic streptozotocin (STZ)-induced rats. Oral administration of 150mg/kg of aqueous oral administration of aqueous pod extract of PV to diabetic rats for 40 days resulted in a significant decrease in blood glucose (p<001), cholesterol (P<0.01) & triglycerides (P<0.01).

3. 3

   High blood pressure, fluid retention, oedema

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Garcia-Mora P (2015)

     Excerpt Aimed at a better exploitation of the functional properties of pinto bean hydrolysates, the effectiveness of two subtilisins (Alcalase & Savinase) for the simultaneous release of bioactive peptides & phenolics with antioxidant, angiotensin I converting enzyme (ACE) inhibitory & anti-inflammatory activities was investigated. The most active hydrolysates combined potent free radical scavenging (326–348 mmol TE/g), ACE inhibitory (IC50 = 0.22–0.26 mg/mL) & anti-inflammatory (28–16% inhibition) activities.

   • According to Oomah BD (2010)

     Excerpt Hulls obtained by mechanical abrasive dehulling from four bean cultivars were extracted with two solvents, aqueous (70%) acetone & water, & the extracts evaluated for antioxidant & anti-inflammatory activities in relation to their phenolic contents. Anti-inflammatory activity of bean hulls was dependent on their phenolic content & antioxidant activity that were significantly affected by cultivar & extracting solvent,.

   • According to Finetti F (2020)

     Excerpt Phaseolus vulgaris L. Fagiola di Venâncio water extract is rich in proteins, sugars & polyphenols & displays antioxidant, anti-inflammatory & antiproliferative activities in in vitro assays on colon cancer cellular models.

   • According to López Barrios L (2016)

     Excerpt The effect of germinating black bean seeds on the production of cotyledon protein hydrolysates (CPH) with antioxidant & antiinflammatory activities was analyzed in this research. Peptides derived from cell wall proteins produced during germination could be responsible of antiinflammatory activity.

   • According to Ganesan K (2017)

     Excerpt Common beans (Phaseolus vulgaris L.) are a greater source of polyphenolic compounds with numerous health promoting properties. Polyphenol-rich dry common beans have potential effects on human health, & possess anti-oxidant, anti-diabetic, anti-obesity, anti-inflammatory & anti-mutagenic & anti-carcinogenic properties.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.