Phyllanthus acidus (Sirèt-Kochon) : medicinal properties in alcoholic extraction

Phyllanthus acidus (Sirèt-Kochon, Pig trap, Surette-à-cochon) — family Euphorbiacées.

Scientific synonyms : AverAverhoa acida Linn, Cicca acida (L.) Merr., C acidissima Blanco, C disticha Linn, C nodiflora Lam., C racemosa Lour., Diasperus acidissimus (Blanco) Kuntze, Phyllanthus acidissimus (Blanco) Muell.-Arg., P cicca Müell.Arg., P cochinchinensis Müell.Arg., P longifolius Jacq., Tricariumm cochinchinense Lour..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 103 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to SHOWMIK A (2010)

     Excerpt A study was carried out to assess the hepatoprotective & hypoglycemic activity of the leaf extracts of Phyllanthus acidus in Wister albino rats against the widely used drugs i.e., Silymarin for hepatoprotective activity & Glibenclamide for hypoglycaemic activity. It also revealed that the alcohol extract of PA leaf possesses hypoglycemic activity at a dose of 200mg/Kg which is as effective as Glibenclamide, a commonly used drug for hypoglycaemic activity.

   • According to YANI S (2025)

     Excerpt The Phyllanthus acidus (L.) Skeels has been used as traditional medicine. It has been proved to have hepatoprotective, anti-inflammatory, antidiabetic, & antioxidant properties.

   • According to Chaimumaom N (2017)

     Excerpt The hypoglycemic effects of PAE on normal rats & orally glucose-induced hyperglycemic rats were compared with distilled water & Glibenclamide. the present study aimed to investigate toxicity & oral glucose tolerance test (OGTT) of Phyllanthus acidus leaf extract (PAE) on Wistar rat.

   • According to RANTI I (2023)

     Excerpt The present work investigated the preventive & attenuating effects of ethanolic extracts of Phyllanthus acidus (PA) & Zingiber aromaticum (ZA) against metabolic disturbances in a high-fat high-fructose (HFHF) diet-induced obesity model. The HFHF diet significantly increased BMI, adiposity index, triglycerides, cholesterol, fasting glucse, insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), leptin, malondialdehyde (MDA) compared with the standard diet.

   • According to CHIGURUPATI S (2020)

     Excerpt PSE’s hypoglycaemic effect was demonstrated in normo- glycemic & streptozotocin-induced (STZ, 55 mg/kg, ip) diabetic rats. The present work examined the antioxidant & antidiabetic potentials of seed extract of Phyllanthus acidus (L.) Skeels.

2. 2

   Liver disorders: cirrhosis, fatty liver

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Jain NK (2010)

     Excerpt To investigate & compare the hepatoprotective effects of crude ethanolic & aqueous extracts of Phyllanthus acidus (L.) Skeels (P. Conclusions: The results of present study suggests that the aqueous extract of PA leaves has significant hepatoprotective activity on APAP & TAA induced hepatotoxicity, which might be associate with its high phenolic & flavonoid content & antioxidant properties.

   • According to SHOWMIK A (2010)

     Excerpt A study was carried out to assess the hepatoprotective & hypoglycemic activity of the leaf extracts of Phyllanthus acidus in Wister albino rats against the widely used drugs i.e., Silymarin for hepatoprotective activity & Glibenclamide for hypoglycaemic activity. Phyllanthus acidus leaves were collected from different localities of Agartala, Tripura, India.

   • According to YANI S (2025)

     Excerpt The Phyllanthus acidus (L.) Skeels has been used as traditional medicine. It has been proved to have hepatoprotective, anti-inflammatory, antidiabetic, & antioxidant properties.

   • According to Hossen MJ (2015)

     Excerpt Hossen MJ et al, AP-1-Targeted Inhibition of Macrophage Function & Lipopolysaccharide/D-Galactosamine-Induced Hepatitis by Phyllanthus acidus Methanolic Extract Am. Moreover, pre-treatment with Pa-ME exhibited strong hepatoprotective and curative effects in an LPS/D-Gal-induced mouse hepatitis model as evidenced by a decrease in elevated serum AST and ALT levels and the amelioration of histological damage.

   • According to Tan SP (2020)

     Excerpt Phyllanthus acidus (L.) Skeels is not only used for its edible fruits but also used to treat a wide spectrum of diseases such as inflammatory, rheumatism, bronchitis, asthma, respiratory disorder, hepatic diseases & diabetes in India, Asia, the Caribbean region, & Central & South America. acidus was collected from various electronic database (ACS, PubMed, Scopus, Web of Science, SciFinder, Science Direct, Google Scholar, Springer, Wiley, Taylor & Mendeley) & also from those published materials (Ph.D.

3. 3

   Diarrhoea

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hossain S (2016)

     Excerpt The study was to evaluate the CNS depressant, antidiarrheal & antipyretic activities of ethanolic leaf extract of Phyllanthus acidus L. In castor oil induced diarrheal model the plant extract reduced thetime of onset & severity of diarrhea with significant (P = 0.05) inhibition of 42.86% & 64.29% for 250 & 500 mg/kg b.w extracts respectively whereas the standard drug loperamide (5 mg/kg) showed 71.43% diarrheal inhibitory activity.

   • According to Nisar MJ (2018)

     Excerpt Phyllanthus species are being in constant used in traditional medications to cure an array of human diseases (constipation, inhalation related, arthritis, loss of appetite, injuries, conjunctivitis, diarrhoea, running nose, common cold, malaria, blennorrhagia, colic, diabetes mellitus, dysentery, indigestion, fever, gout, gonorrheal diseases of males & females, skin itching, jaundice, hepatic disorders, leucorrhea, vaginitis, menstrual irregularities, obesity, stomach pains, & tumors), confectionaries, food industry, & in some pesticides. Phyllanthus is one of the largest genera in the family Phyllanthaceae, comprising over 700 well known species cosmopolitan in distribution mainly in the tropics & subtropics.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.