Phyllanthus amarus (Grenn-anba-fèy) : medicinal properties in alcoholic extraction

Phyllanthus amarus (Grenn-anba-fèy, Seed-at-the-base-of-the-leaf, Graine-en-bas-de-feuille) — family Phyllantacées.

Scientific synonyms : Diasperus nanus (Hook.f.) Kuntze, Phyllanthus nanus-Hook.f, P niruri var amarus-(S & T)-Leandr, P niruri var scabrellus-((W)-M, P scabrellus-Webb, P swartzii-Kosei.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 20 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 116 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sureban S (2006)

     Excerpt These findings demonstrate that Phyllanthus extracts induce TNF-α production from the hepatocellular carcinoma cells while inhibiting production of potent anti-apoptotic genes IL-8 & COX-2,. amarus is a medicinal plant with hepatoprotective activity, believed to occur in part by inhibiting hepatitis B virus function.

   • According to BOSE A (2022)

     Excerpt PA extracts have shown a broad range of pharmacological activities like hepatoprotective, antioxidant, antiviral, antimicrobial, antidiabetic, anti-inflammatory, anticancer, antimalarial, nephroprotective, diuretic, & several other properties. BOSE A et al, An insight into the potent medicinal plant Phyllanthus amarus Schum.

   • According to Blumberg BS (1990)

     Excerpt Blumberg BS et al, Hepatitis B virus & primary hepatocellular carcinoma: treatment of HBV carriers with Phyllanthus amarus.

   • According to Jeena KL (1999)

     Excerpt The anticarcinogenic activity of these extracts were evaluated by their effect on tumour incidence, levels of carcinogen metabolizing enzymes, levels of liver cancer markers and liver injury markers. Extracts of Emblica officinalis (EO), Phyllanthus amarus & Picrorhiza kurroa significantly inhibited hepatocarcinogenesis induced by N-Nitrosodiethylamine (NDEA) in a dose dependent manner.

   • According to Chattopadhyay P (2007)

     Excerpt The blood sample were collected from the abdominal aorta & the serum insulin estimated by radio Immuno assay & regenerative capacity measured by thymidine kinase assay by 3H thymidine incorporation into hepatic DNA which showed that P amarus has a potential role in insulin action during liver cell regeneration. The hydroalcoholic extract of whole plant of Phyllanthus amarus showed significant increase in activity of insulin at 200 mg kg-1 dose in regenerative hepatocytes against alcohol induced liver cell injury in partially hepatectomized albino rats.

2. 2

   Neuroinflammation: memory impairment, demyelination, diabetic peripheral neuropathy

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Srilatha K (2020)

     Excerpt Results: The diabetic rats showed increased HbA1c, nitrite, MPO, calcium & decreased protein, Na+-K+ ATPase activity, NCV, acetylcholine, behavioural alterations and morphological changes of sciatic nerve so that diabetic peripheral neuropathy (DPN) is manifested. Diabetes-instigated nerve damage is a chronic complication including impaired peripheral nerve function with lowered nerve conduction velocity (NCV), demyelination of nerve fibres & alterations in the behaviour.

   • According to Chattopadhyay P (2007)

     Excerpt The hydroalcoholic extract of whole plant of Phyllanthus amarus showed significant increase in activity of insulin at 200 mg kg-1 dose in regenerative hepatocytes against alcohol induced liver cell injury in partially hepatectomized albino rats. The blood sample were collected from the abdominal aorta & the serum insulin estimated by radio Immuno assay & regenerative capacity measured by thymidine kinase assay by 3H thymidine incorporation into hepatic DNA which showed that P amarus has a potential role in insulin action during liver cell regeneration.

   • According to Lawson-Evi P (n.d.)

     Excerpt This study was undertaken to investigate the antidiabetic effect of aqueous & hydroalcoholic extract of Phyllanthus amarus, a medicinal plant used in Togo for treating diabetes & many others diseases. This study demonstrated the potential antidiabetic property of aqueous & hydroalcoholic extract of P amarus thus justifying its traditional usage.

   • According to Matou M (2023)

     Excerpt Extracts of the aerial part of Phyllanthus amarus have been extensively used in several countries to cure diabetes. amarus extracted by an infusion method that are responsible for antidiabetic effects occurring at the level of glucose homeostasis.

   • According to BOSE A (2022)

     Excerpt BOSE A et al, An insight into the potent medicinal plant Phyllanthus amarus Schum. 2022-Abstract Phyllanthus amarus Schum.

3. 3

   Type II diabetes mellitus

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lawson-Evi P (n.d.)

     Excerpt This study was undertaken to investigate the antidiabetic effect of aqueous & hydroalcoholic extract of Phyllanthus amarus, a medicinal plant used in Togo for treating diabetes & many others diseases. After 15 days treatment, body weight gain, blood glucose level, serum insulin, total cholesterol, triglycerides & Malondialdehyde were evaluated.

   • According to Matou M (2023)

     Excerpt amarus extracted by an infusion method that are responsible for antidiabetic effects occurring at the level of glucose homeostasis. Extracts of the aerial part of Phyllanthus amarus have been extensively used in several countries to cure diabetes.

   • According to Moshi MJ (2001)

     Excerpt Moshi MJ et al, The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients.

   • According to Chattopadhyay P (2007)

     Excerpt The hydroalcoholic extract of whole plant of Phyllanthus amarus showed significant increase in activity of insulin at 200 mg kg-1 dose in regenerative hepatocytes against alcohol induced liver cell injury in partially hepatectomized albino rats. The blood sample were collected from the abdominal aorta & the serum insulin estimated by radio Immuno assay & regenerative capacity measured by thymidine kinase assay by 3H thymidine incorporation into hepatic DNA which showed that P amarus has a potential role in insulin action during liver cell regeneration.

   • According to Srilatha K (2020)

     Excerpt Many clinical & experimental studies have proved that Phyllanthus amarus & esculetin have potential effects against various diseases. Purpose: The aim of this study is to assess the neuroprotective role of hydro-ethanolic extract of PA (PAE) & esculetin (ESC) on NCV, metabolism, behavioural & structural changes in diabetic rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.