Phyllanthus amarus (Grenn-anba-fèy) : vertus médicinales en extraction alcoolique

Phyllanthus amarus (Grenn-anba-fèy, Graine-en-bas-de-feuille, Seed-at-the-base-of-the-leaf) — famille Phyllantacées.

Synonymes scientifiques : Diasperus nanus (Hook.f.) Kuntze, Phyllanthus nanus-Hook.f, P niruri var amarus-(S & T)-Leandr, P niruri var scabrellus-((W)-M, P scabrellus-Webb, P swartzii-Kosei.

Sources externes reconnues associées à cette monographie : TRAMIL.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 20 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 116 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome hépatique

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Sureban S (2006)

     Extrait These findings demonstrate that Phyllanthus extracts induce TNF-α production from the hepatocellular carcinoma cells while inhibiting production of potent anti-apoptotic genes IL-8 & COX-2,. amarus is a medicinal plant with hepatoprotective activity, believed to occur in part by inhibiting hepatitis B virus function.

   • Selon BOSE A (2022)

     Extrait PA extracts have shown a broad range of pharmacological activities like hepatoprotective, antioxidant, antiviral, antimicrobial, antidiabetic, anti-inflammatory, anticancer, antimalarial, nephroprotective, diuretic, & several other properties. BOSE A et al, An insight into the potent medicinal plant Phyllanthus amarus Schum.

   • Selon Blumberg BS (1990)

     Extrait Blumberg BS et al, Hepatitis B virus & primary hepatocellular carcinoma: treatment of HBV carriers with Phyllanthus amarus.

   • Selon Jeena KL (1999)

     Extrait The anticarcinogenic activity of these extracts were evaluated by their effect on tumour incidence, levels of carcinogen metabolizing enzymes, levels of liver cancer markers and liver injury markers. Extracts of Emblica officinalis (EO), Phyllanthus amarus & Picrorhiza kurroa significantly inhibited hepatocarcinogenesis induced by N-Nitrosodiethylamine (NDEA) in a dose dependent manner.

   • Selon Chattopadhyay P (2007)

     Extrait The blood sample were collected from the abdominal aorta & the serum insulin estimated by radio Immuno assay & regenerative capacity measured by thymidine kinase assay by 3H thymidine incorporation into hepatic DNA which showed that P amarus has a potential role in insulin action during liver cell regeneration. The hydroalcoholic extract of whole plant of Phyllanthus amarus showed significant increase in activity of insulin at 200 mg kg-1 dose in regenerative hepatocytes against alcohol induced liver cell injury in partially hepatectomized albino rats.

2. 2

   Neuroinflammation : trouble mnésique, démyélinisation, neuropathie périphérique du diabétique

   Partie usitée : Plante entière.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Srilatha K (2020)

     Extrait Results: The diabetic rats showed increased HbA1c, nitrite, MPO, calcium & decreased protein, Na+-K+ ATPase activity, NCV, acetylcholine, behavioural alterations and morphological changes of sciatic nerve so that diabetic peripheral neuropathy (DPN) is manifested. Diabetes-instigated nerve damage is a chronic complication including impaired peripheral nerve function with lowered nerve conduction velocity (NCV), demyelination of nerve fibres & alterations in the behaviour.

   • Selon Chattopadhyay P (2007)

     Extrait The hydroalcoholic extract of whole plant of Phyllanthus amarus showed significant increase in activity of insulin at 200 mg kg-1 dose in regenerative hepatocytes against alcohol induced liver cell injury in partially hepatectomized albino rats. The blood sample were collected from the abdominal aorta & the serum insulin estimated by radio Immuno assay & regenerative capacity measured by thymidine kinase assay by 3H thymidine incorporation into hepatic DNA which showed that P amarus has a potential role in insulin action during liver cell regeneration.

   • Selon Lawson-Evi P (s.d.)

     Extrait This study was undertaken to investigate the antidiabetic effect of aqueous & hydroalcoholic extract of Phyllanthus amarus, a medicinal plant used in Togo for treating diabetes & many others diseases. This study demonstrated the potential antidiabetic property of aqueous & hydroalcoholic extract of P amarus thus justifying its traditional usage.

   • Selon Matou M (2023)

     Extrait Extracts of the aerial part of Phyllanthus amarus have been extensively used in several countries to cure diabetes. amarus extracted by an infusion method that are responsible for antidiabetic effects occurring at the level of glucose homeostasis.

   • Selon BOSE A (2022)

     Extrait BOSE A et al, An insight into the potent medicinal plant Phyllanthus amarus Schum. 2022-Abstract Phyllanthus amarus Schum.

3. 3

   Diabète mellitus de type II

   Partie usitée : Plante entière.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Lawson-Evi P (s.d.)

     Extrait This study was undertaken to investigate the antidiabetic effect of aqueous & hydroalcoholic extract of Phyllanthus amarus, a medicinal plant used in Togo for treating diabetes & many others diseases. After 15 days treatment, body weight gain, blood glucose level, serum insulin, total cholesterol, triglycerides & Malondialdehyde were evaluated.

   • Selon Matou M (2023)

     Extrait amarus extracted by an infusion method that are responsible for antidiabetic effects occurring at the level of glucose homeostasis. Extracts of the aerial part of Phyllanthus amarus have been extensively used in several countries to cure diabetes.

   • Selon Moshi MJ (2001)

     Extrait Moshi MJ et al, The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients.

   • Selon Chattopadhyay P (2007)

     Extrait The hydroalcoholic extract of whole plant of Phyllanthus amarus showed significant increase in activity of insulin at 200 mg kg-1 dose in regenerative hepatocytes against alcohol induced liver cell injury in partially hepatectomized albino rats. The blood sample were collected from the abdominal aorta & the serum insulin estimated by radio Immuno assay & regenerative capacity measured by thymidine kinase assay by 3H thymidine incorporation into hepatic DNA which showed that P amarus has a potential role in insulin action during liver cell regeneration.

   • Selon Srilatha K (2020)

     Extrait Many clinical & experimental studies have proved that Phyllanthus amarus & esculetin have potential effects against various diseases. Purpose: The aim of this study is to assess the neuroprotective role of hydro-ethanolic extract of PA (PAE) & esculetin (ESC) on NCV, metabolism, behavioural & structural changes in diabetic rats.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.