Phyllanthus niruri (Grenn ’-anba-fèy) : medicinal properties in alcoholic extraction

Phyllanthus niruri (Grenn ’-anba-fèy, Seed at the base of the leaf, Graine-en bas de feuille) — family Phyllantacées.

Scientific synonyms : Phyllanthus niruri subsp. Lathyroides (Kunth) G.L.Webster, sous-espèce Phyllanthus niruri subsp. Niruri.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 158 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Whole plant. Mentioned synergistic association: Andrographis paniculata-plante entière.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Araujo RF Jr (2012)

     Excerpt To investigate the cytotoxic effects of spray-dried extracts of Phyllanthus niruri in combination with cisplatin on two cancer cell lines. METHODS: Colorectal carcinoma (HT29) & human hepatocellular carcinoma (HepG2) cells were treated with spray-dried extracts of PN (SDEPN) either alone or in combination with cisplatin at different concentrations (0.5 mg/mL & 1 mg/mL) for 4 h & 24 h.

   • According to Kaur N (2017)

     Excerpt The genus Phyllanthus has been used in traditional medicine for its wide range of pharmacological activities like antimicrobial, antioxidant, anticancer, antiinflammatory, antiplasmodial, antiviral, diuretic & hepatoprotective. Phyllanthus niruri, a typical member of family Euphorbiaceae, is a small annual herb found throughout the tropical & subtropical regions of both hemispheres.

   • According to You Y (2021)

     Excerpt Hence, in this work, we investigated the protective role of phyllanthin on diethylnitrosamine (DEN) induced liver carcinoma in Wistar Albino rats and the anti-tumor potential on human hepatocellular carcinoma (HCC) HepG2 cells. The DEN-challenged liver cancer in experimental rats caused increased liver weight, 8-OHD, hepatic tissue injury marker, lipid peroxidation, & tumor markers levels.

   • According to HARTANI D (2022)

     Excerpt Composition: -Andrographis paniculata: PA: ,,,,,,,,,,,,,,,5 gr -Orthosiphon aristatus: PA: ,,,,,,,,,,,,,,,,,,,,3 gr -Syzygium polyanthum: FE: ,,,,,,,,,,,,,,,,,,,,,,,,,5 gr: -Cinnamomum verum: EC: ,,,,,,,,,,,,,,,,,,,,,,,7 gr -Curcuma Zedoaria: RHZ: ,,,,,,,,,,,,,,,,,,,,,,,,15 gr -Curcuma longa: RHZ: ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,10gr -Phyllanthus niruri: PA: ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,5 gr,. This study evaluated the selected pharmacognostic characters, antioxidant activities, total phenolic content, & the hepatic safety of a polyherbal formulation containing seven plant constituents used by Klinik Wisata Kesehatan Jamu Kalibakung, Tegal, Indonesia, to treat diabetes patients.

   • According to Harish R (2006)

     Excerpt Antioxidant activity & hepatoprotective potential of Phyllanthus niruri, a widely used medicinal plant, were investigated. CCl4 – induced hepatotoxicity in rats, as judged by the raised serum enzymes, glutamate oxaloacetate transaminase (GOT) & glutamate pyruvate transaminase (GPT), was prevented by pretreatment with the extracts, demonstrating the hepatoprotective action of P.

2. 2

   Type II diabetes mellitus

   Plant part used: aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Okoli CO (2011)

     Excerpt The effects of methanol extract of aerial parts of Phyllanthus niruri L. (Euphorbiaceae), an antidiabetic herb, on glucose absorption & storage in diabetes were studied to elucidate the mechanisms of blood glucose lowering & glycemic control in diabetes.

   • According to Okoli CO (2010)

     Excerpt The antidiabetic potentials of methanol extract (ME) of aerial parts of Phyllanthus niruri L (Euphorbiaceae) was evaluated in normal and alloxan diabetic rats. Results suggest that extract of aerial parts of PN has great potentials as anti-diabetic remedy,.

   • According to Mazumder UK (2005)

     Excerpt the present investigation shows the anti- hyperglycemic activity of methanol extract of Phyllanthus niruri (MEPN) in Streptozotocin (STZ) induced diabetic male Wistar rats. The de- creased levels of Thiobarbituric acid reactive substances (TBARS) & increased levels of reduced glutathione (GSH), and the activities of superoxide dismutase (SOD) & Catalase (CAT) resulted in reducing the free radical formation in various tissues such as liver, kidney, hear& brain of the diabetic rats.

   • According to Yaman E (2020)

     Excerpt The combination of Phyllanthus niruri herbs & Zingiber americans rhizome has been produced as herbal medicine for the treatment of diabetes. While the decrease in blood glucose levels in alloxan induced method were 33.05, 38.82, & 41.79% at dose 90, 135, and 203 mg/kg BW, respectively (p <0.05) compared to control.

   • According to WONG PL (2026)

     Excerpt Data from 2010 to 2025 for in vitro & in vivo antidiabetic studies demonstrated the capability of Phyllanthus species as anti‐hyperglycemic agent. Overall, this review offers a comprehensive insight into the role of bioactive phytoconstituents in Phyllanthus species & enhance the prospects in the advancement of functional food ingredients & drug discovery for diabetes management.

3. 3

   Hepatitis, cirrhosis, fatty liver

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sowjanya K (2021)

     Excerpt Phyllanthus niruri, a traditional herbal medicine, was found to be hepatoprotective as evidenced by several preclinical & clinical studies. Materials & methods: The present study is a block randomized, double-blind, parallel-arm placebo-controlled trial that was designed to assess the efficacy of PN on the liver & renal function parameters, total oxidant & antioxidant levels in alcoholic hepatitis patients in comparison to placebo over a 4-week period.

   • According to Liu S (2014)

     Excerpt Furthermore, analysis of the liver pathological changes confirmed the hepatoprotective effect of niranthin. Niranthin is a lignan isolated from Phyllanthus niruri L.

   • According to Shanmugam B (2017)

     Excerpt This is the first report on the antioxidant enzymes & hepatoprotective effect of (-)-epicatechin in hepatitis rats,. The hepatic antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), & glutathione reductase (GR), glutathione S-transferase (GST), reduced glutathione (GSH), & malondialdehyde (MDA) & serum markers aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin, & bilirubin are estimated.

   • According to Harish R (2006)

     Excerpt Antioxidant activity & hepatoprotective potential of Phyllanthus niruri, a widely used medicinal plant, were investigated. CCl4 – induced hepatotoxicity in rats, as judged by the raised serum enzymes, glutamate oxaloacetate transaminase (GOT) & glutamate pyruvate transaminase (GPT), was prevented by pretreatment with the extracts, demonstrating the hepatoprotective action of P.

   • According to Okoli CO (2011)

     Excerpt The effects of methanol extract of aerial parts of Phyllanthus niruri L. Effects on glucose mobilization & storage were assessed using the weight & glycogen content of liver isolated from treated diabetic rats, while in vitro inhibition of α-amylase & α-glucosidase enzyme activities were used as indices of effect on glucose absorption.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.