Phyllanthus niruri (Grenn ’-anba-fèy) : vertus médicinales en extraction alcoolique

Phyllanthus niruri (Grenn ’-anba-fèy, Graine-en bas de feuille, Seed at the base of the leaf) — famille Phyllantacées.

Synonymes scientifiques : Phyllanthus niruri subsp. Lathyroides (Kunth) G.L.Webster, sous-espèce Phyllanthus niruri subsp. Niruri.

Sources externes reconnues associées à cette monographie : TRAMIL.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 16 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 157 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Parties aériennes.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Okoli CO (2011)

     Extrait The effect of chronic oral administration of the extract on glycemic control was evaluated in alloxan diabetic rats using blood glucose lowering & post-prandial glucose suppression activities as well as effects on hemoglobin glycation & body weight. (Euphorbiaceae), an antidiabetic herb, on glucose absorption & storage in diabetes were studied to elucidate the mechanisms of blood glucose lowering & glycemic control in diabetes.

   • Selon Okoli CO (2010)

     Extrait The antidiabetic potentials of methanol extract (ME) of aerial parts of Phyllanthus niruri L (Euphorbiaceae) was evaluated in normal and alloxan diabetic rats. Sub-chronic toxicity study showed that ME-treated rats had significant (P<0.05) reductions in haemoglobin (Hb) levels, red blood cell (RBC) & white blood cell (WBC) counts followed by a gradual rise which did not, however, attain basal levels; however, there was a progressive rise in the WBC of ME-treated diabetic rats.

   • Selon Mazumder UK (2005)

     Extrait the present investigation shows the anti- hyperglycemic activity of methanol extract of Phyllanthus niruri (MEPN) in Streptozotocin (STZ) induced diabetic male Wistar rats. The de- creased levels of Thiobarbituric acid reactive substances (TBARS) & increased levels of reduced glutathione (GSH), and the activities of superoxide dismutase (SOD) & Catalase (CAT) resulted in reducing the free radical formation in various tissues such as liver, kidney, hear& brain of the diabetic rats.

   • Selon Yaman E (2020)

     Extrait The combination of Phyllanthus niruri herbs & Zingiber americans rhizome has been produced as herbal medicine for the treatment of diabetes. While the decrease in blood glucose levels in alloxan induced method were 33.05, 38.82, & 41.79% at dose 90, 135, and 203 mg/kg BW, respectively (p <0.05) compared to control.

   • Selon WONG PL (2026)

     Extrait Data from 2010 to 2025 for in vitro & in vivo antidiabetic studies demonstrated the capability of Phyllanthus species as anti‐hyperglycemic agent. Overall, this review offers a comprehensive insight into the role of bioactive phytoconstituents in Phyllanthus species & enhance the prospects in the advancement of functional food ingredients & drug discovery for diabetes management.

2. 2

   Hépatite, cirrhose, stéatose hépatique

   Partie usitée : Plante entière.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Sowjanya K (2021)

     Extrait Phyllanthus niruri, a traditional herbal medicine, was found to be hepatoprotective as evidenced by several preclinical & clinical studies. Materials & methods: The present study is a block randomized, double-blind, parallel-arm placebo-controlled trial that was designed to assess the efficacy of PN on the liver & renal function parameters, total oxidant & antioxidant levels in alcoholic hepatitis patients in comparison to placebo over a 4-week period.

   • Selon Liu S (2014)

     Extrait Furthermore, analysis of the liver pathological changes confirmed the hepatoprotective effect of niranthin. Niranthin is a lignan isolated from Phyllanthus niruri L.

   • Selon Shanmugam B (2017)

     Extrait This is the first report on the antioxidant enzymes & hepatoprotective effect of (-)-epicatechin in hepatitis rats,. The hepatic antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), & glutathione reductase (GR), glutathione S-transferase (GST), reduced glutathione (GSH), & malondialdehyde (MDA) & serum markers aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin, & bilirubin are estimated.

   • Selon Harish R (2006)

     Extrait Antioxidant activity & hepatoprotective potential of Phyllanthus niruri, a widely used medicinal plant, were investigated. CCl4 – induced hepatotoxicity in rats, as judged by the raised serum enzymes, glutamate oxaloacetate transaminase (GOT) & glutamate pyruvate transaminase (GPT), was prevented by pretreatment with the extracts, demonstrating the hepatoprotective action of P.

   • Selon Okoli CO (2011)

     Extrait The effects of methanol extract of aerial parts of Phyllanthus niruri L. Effects on glucose mobilization & storage were assessed using the weight & glycogen content of liver isolated from treated diabetic rats, while in vitro inhibition of α-amylase & α-glucosidase enzyme activities were used as indices of effect on glucose absorption.

3. 3

   Cancer: traitement adjuvant du carcinome mammaire triple négatif

   Partie usitée : Plante entière. Association synergique mentionnée : Curcuma longa-rhizome.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon HERMANSYAH D (2023)

     Extrait Curcuma longa extract (CL) & Phyllanthus niruri extract (PN) known to have anti-proliferative effects on cancer cells. Triple negative breast cancer cells (TNBC) are a small part of cancer-inducing cells in breast cancer, which are characterized by high metastatic & self-renewal.

   • Selon Sharma P (2009)

     Extrait The present study was carried out to evaluate the anti-tumor activity of a hydro-alcoholic extract of the whole plant, in 7–9-week-old male Swiss albino mice, on the two-stage process of skin carcinogenesis induced by a single topical application of 7, 12-dimethyl-benz (a)anthracene (100 microg/100 microl acetone) & two weeks later promoted by repeated application of croton oil (1% in acetone/three times a week) till the end of experiment (16 weeks). Phyllanthus niruri is a well-known medicinal plant which has been used in Ayurvedic medicine as hepatoprotective, antiviral, antibacterial, analgesic, antispasmodic & antidiabetic.

   • Selon Jia L (2013)

     Extrait The aim of the present study is to investigate the anticancer properties of Corilagin in ovarian cancer cells. Phyllanthus niruri L.

   • Selon Raja W (2019)

     Extrait In the present investigation, the anticancer activity of Phyllanthus niruri root extract was evaluated using two stage skin carcinogenesis in Swiss albino mice, induced by a single application of 7,12-dimethyadenz(a)anthracene (104 μg/100 μl acetone) and one weeks later, promoted by repeated application of croton oil (1% in acetone/thrice a week) till the end of the experiment (16 weeks). Phyllanthus niruri is a well-known medicinal plant which has been used in Ayurvedic medicine as hepatoprotective, antiviral, antibacterial, analgesic, antispasmodic & antidiabetic.

   • Selon Araujo RF Jr (2012)

     Extrait To investigate the cytotoxic effects of spray-dried extracts of Phyllanthus niruri in combination with cisplatin on two cancer cell lines. METHODS: Colorectal carcinoma (HT29) & human hepatocellular carcinoma (HepG2) cells were treated with spray-dried extracts of PN (SDEPN) either alone or in combination with cisplatin at different concentrations (0.5 mg/mL & 1 mg/mL) for 4 h & 24 h.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.