Phyllantus urinaria (Red-leaved seed at the base) : medicinal properties in alcoholic extraction

Phyllantus urinaria (Red-leaved seed at the base, Grenn anba fèy wouj, Graine-en-bas de-feuille rouge) — family Euphorbiacées.

Scientific synonyms : Diasperus urinaria (L.) Kuntze, Phyllanthus cantonensis-L, P leprocarpus-Wight, P rubens-Bpjer ex Baker.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 75 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for liver and lung carcinomas, Lewis carcinoma and osteosarcoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chudapongse N (2010)

     Excerpt To investigate the cytotoxic effect of Phyllanthus urinaria extract on human hepatocellular carcinoma HepG2 cells & the effect on oxidative phosphorylation by isolated rat liver mitochondria. These results provide preliminary experimental evidence supporting the use of PU against hepatocellular carcinoma & open the possibility of considering this plant an adjunctive medicine for the treatment of this deadly disease.

   • According to Tong GD (2014)

     Excerpt Efficacy of early treatment on 52 patients with preneoplastic hepatitis B virus-associated hepatocellular carcinoma by compound Phyllanthus Urinaria L.

   • According to Sureban S (2006)

     Excerpt These findings demonstrate that Phyllanthus extracts induce TNF-α production from the hepatocellular carcinoma cells while inhibiting production of potent anti-apoptotic genes IL-8 & COX-2,. debilis in regulating cell proliferation & gene expression activities of HepG2 hepatocellular carcinoma cells.

   • According to Hau DKP (2009)

     Excerpt In this study we investigated whether mice, administered intraperitoneally with a lethal dose of acetaminophen, when followed by oral administration of Phyllanthus urinaria extract, may be prevented from death. We conclude that PU extract is effective in attenuating the acetaminophen induced hepatotoxicity, & inhibition of cytochrome P450 CYP2E1 enzyme may be an important factor for its therapeutic mechanism.

   • According to Guo Q (2017)

     Excerpt The results suggested that the potential hepatoprotective effects of PUL in attenuating CCl4-induced hepatotoxicity could be partially attributed to regulating L-carnitine, taurocholic acid, & amino acids metabolism, which may become promising targets for treatment of liver toxicity. Seventeen biomarkers related to the hepatoprotective effects of PUL against CCl4-induced liver injury were screened out using nonparametric test & Pearson's correlation analysis (OPLS-DA).

2. 2

   Type II diabetes mellitus

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Higashino H (1992)

     Excerpt Hypoglycemic effects of the extracts of two Siamese plants, Momordica charantia (M.c.) & Phyllanthus urinaria (P.u.), were examined in streptozotocin-induced diabetic rats. These plants generally contain moderately non-polar hypoglycemic compound(s) soluble in n-butanol; & specifically, with regards to the hypoglycemic mechanism, the M.c.

   • According to Akhtar Nadeem M (2015)

     Excerpt The objective of this research was to analyze the anti-diabetic properties of the bioactive compounds extracted from P. The present study confirms the fact that the bioactive so obtained possess efficient anti-diabetic properties.

   • According to Trinh BTD (2016)

     Excerpt Results : Ethanol extracts of Nepenthes mirabilis, Phyllanthus urinaria, & Kandelia candel significantly inhibited α-glucosidase with IC50 values of 32.7±6.3, 39.7±9.7, & 35.4±13.9 μg/mL, respectively. The 18 plant species investigated in this study have been used as herbal antidiabetic remedies in Vietnamese traditional medicines.

   • According to Tang YQ (2010)

     Excerpt The main aim of the present work was to investigate the potential cytotoxic effects of aqueous & methanolic extracts of four Phyllanthus species (P.amarus, P.niruri, P.urinaria & P.watsonii) against skin melanoma & prostate cancer cells. Phyllanthus is a traditional medicinal plant that has been used in the treatment of many diseases including hepatitis & diabetes.

   • According to Geethangili M (2018)

     Excerpt Pharmacological activities include anticancer, hepatoprotective, antidiabetic, antimicrobial, & cardioprotective effects. PU is used in folk medicine as a cure to treat jaundice, diabetes, malaria, & liver diseases.

3. 3

   Liver disorders: cirrhosis, hepatitis, fatty liver disease (BREVET)

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Tong GD (2014)

     Excerpt Efficacy of early treatment on 52 patients with preneoplastic hepatitis B virus-associated hepatocellular carcinoma by compound Phyllanthus Urinaria L.

   • According to Zhou S (1997)

     Excerpt Zhou S et al, Mechanism of protective action of Phyllanthus urinaria L.

   • According to Guo Q (2017)

     Excerpt The results suggested that the potential hepatoprotective effects of PUL in attenuating CCl4-induced hepatotoxicity could be partially attributed to regulating L-carnitine, taurocholic acid, & amino acids metabolism, which may become promising targets for treatment of liver toxicity. GC/MS & LC/MS-based untargeted metabolomics were used in combination to characterize the potential biomarkers associated with the protective activity of PUL against CCl4-induced liver injury in rats.

   • According to Sureban S (2006)

     Excerpt amarus is a medicinal plant with hepatoprotective activity, believed to occur in part by inhibiting hepatitis B virus function. These findings demonstrate that Phyllanthus extracts induce TNF-α production from the hepatocellular carcinoma cells while inhibiting production of potent anti-apoptotic genes IL-8 & COX-2,.

   • According to Hau DKP (2009)

     Excerpt In this study we investigated whether mice, administered intraperitoneally with a lethal dose of acetaminophen, when followed by oral administration of Phyllanthus urinaria extract, may be prevented from death. We conclude that PU extract is effective in attenuating the acetaminophen induced hepatotoxicity, & inhibition of cytochrome P450 CYP2E1 enzyme may be an important factor for its therapeutic mechanism.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.