Phyllantus urinaria (Grenn anba fèy wouj) : vertus médicinales en extraction alcoolique

Phyllantus urinaria (Grenn anba fèy wouj, Graine-en-bas de-feuille rouge, Red-leaved seed at the base) — famille Euphorbiacées.

Synonymes scientifiques : Diasperus urinaria (L.) Kuntze, Phyllanthus cantonensis-L, P leprocarpus-Wight, P rubens-Bpjer ex Baker.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 10 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 75 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinom è hépatique, pulmonaire de Lewis & de l’ostéosarcome

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Chudapongse N (2010)

     Extrait To investigate the cytotoxic effect of Phyllanthus urinaria extract on human hepatocellular carcinoma HepG2 cells & the effect on oxidative phosphorylation by isolated rat liver mitochondria. These results provide preliminary experimental evidence supporting the use of PU against hepatocellular carcinoma & open the possibility of considering this plant an adjunctive medicine for the treatment of this deadly disease.

   • Selon Tong GD (2014)

     Extrait Efficacy of early treatment on 52 patients with preneoplastic hepatitis B virus-associated hepatocellular carcinoma by compound Phyllanthus Urinaria L.

   • Selon Sureban S (2006)

     Extrait These findings demonstrate that Phyllanthus extracts induce TNF-α production from the hepatocellular carcinoma cells while inhibiting production of potent anti-apoptotic genes IL-8 & COX-2,. debilis in regulating cell proliferation & gene expression activities of HepG2 hepatocellular carcinoma cells.

   • Selon Hau DKP (2009)

     Extrait In this study we investigated whether mice, administered intraperitoneally with a lethal dose of acetaminophen, when followed by oral administration of Phyllanthus urinaria extract, may be prevented from death. We conclude that PU extract is effective in attenuating the acetaminophen induced hepatotoxicity, & inhibition of cytochrome P450 CYP2E1 enzyme may be an important factor for its therapeutic mechanism.

   • Selon Guo Q (2017)

     Extrait The results suggested that the potential hepatoprotective effects of PUL in attenuating CCl4-induced hepatotoxicity could be partially attributed to regulating L-carnitine, taurocholic acid, & amino acids metabolism, which may become promising targets for treatment of liver toxicity. Seventeen biomarkers related to the hepatoprotective effects of PUL against CCl4-induced liver injury were screened out using nonparametric test & Pearson's correlation analysis (OPLS-DA).

2. 2

   Diabète mellitus de type II

   Partie usitée : Plante entière.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Higashino H (1992)

     Extrait Hypoglycemic effects of the extracts of two Siamese plants, Momordica charantia (M.c.) & Phyllanthus urinaria (P.u.), were examined in streptozotocin-induced diabetic rats. These plants generally contain moderately non-polar hypoglycemic compound(s) soluble in n-butanol; & specifically, with regards to the hypoglycemic mechanism, the M.c.

   • Selon Akhtar Nadeem M (2015)

     Extrait The objective of this research was to analyze the anti-diabetic properties of the bioactive compounds extracted from P. The present study confirms the fact that the bioactive so obtained possess efficient anti-diabetic properties.

   • Selon Trinh BTD (2016)

     Extrait Results : Ethanol extracts of Nepenthes mirabilis, Phyllanthus urinaria, & Kandelia candel significantly inhibited α-glucosidase with IC50 values of 32.7±6.3, 39.7±9.7, & 35.4±13.9 μg/mL, respectively. The 18 plant species investigated in this study have been used as herbal antidiabetic remedies in Vietnamese traditional medicines.

   • Selon Tang YQ (2010)

     Extrait The main aim of the present work was to investigate the potential cytotoxic effects of aqueous & methanolic extracts of four Phyllanthus species (P.amarus, P.niruri, P.urinaria & P.watsonii) against skin melanoma & prostate cancer cells. Phyllanthus is a traditional medicinal plant that has been used in the treatment of many diseases including hepatitis & diabetes.

   • Selon Geethangili M (2018)

     Extrait Pharmacological activities include anticancer, hepatoprotective, antidiabetic, antimicrobial, & cardioprotective effects. PU is used in folk medicine as a cure to treat jaundice, diabetes, malaria, & liver diseases.

3. 3

   Troubles hépatique : cirrhose, hépatite, stéatose hépatique (BREVET)

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Tong GD (2014)

     Extrait Efficacy of early treatment on 52 patients with preneoplastic hepatitis B virus-associated hepatocellular carcinoma by compound Phyllanthus Urinaria L.

   • Selon Zhou S (1997)

     Extrait Zhou S et al, Mechanism of protective action of Phyllanthus urinaria L.

   • Selon Guo Q (2017)

     Extrait The results suggested that the potential hepatoprotective effects of PUL in attenuating CCl4-induced hepatotoxicity could be partially attributed to regulating L-carnitine, taurocholic acid, & amino acids metabolism, which may become promising targets for treatment of liver toxicity. GC/MS & LC/MS-based untargeted metabolomics were used in combination to characterize the potential biomarkers associated with the protective activity of PUL against CCl4-induced liver injury in rats.

   • Selon Sureban S (2006)

     Extrait amarus is a medicinal plant with hepatoprotective activity, believed to occur in part by inhibiting hepatitis B virus function. These findings demonstrate that Phyllanthus extracts induce TNF-α production from the hepatocellular carcinoma cells while inhibiting production of potent anti-apoptotic genes IL-8 & COX-2,.

   • Selon Hau DKP (2009)

     Extrait In this study we investigated whether mice, administered intraperitoneally with a lethal dose of acetaminophen, when followed by oral administration of Phyllanthus urinaria extract, may be prevented from death. We conclude that PU extract is effective in attenuating the acetaminophen induced hepatotoxicity, & inhibition of cytochrome P450 CYP2E1 enzyme may be an important factor for its therapeutic mechanism.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.