Pimpinella anisum (Lanni) : medicinal properties in alcoholic extraction

Pimpinella anisum (Lanni, Anis) — family Apiacées.

Scientific synonyms : Anisum odoratum-Raf, A officinale-DC, Apium anisum-(L)-Crantz, Selinum anisum-(L)-EHL-K, Tragium anisum-(L)-Link.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 14 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 69 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for gastric and prostate carcinoma

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rahamoz-Haghighi S (2016)

     Excerpt In the present study, we investigated the cytotoxic effect of alcoholic extracts & essential oil of Pimpinella anisum on viability of gastric cancer cell line (AGS) & angiogenesis of HUVEC cells . Conclusion: Therefore, our results showed that the alcoholic extracts & essential oil of PA have antiprolifertion properties on gastric cancer cells & could be used as plant-based cures for gastric cancer.

   • According to Author (2013)

     Excerpt In this study, anticancer activity of ethanol extract of Pimpinella anisum seed was investigated. MTT & LDH assays revealed that ethanolic extract have cytotoxic activity on human prostate cancer cell line [PC-3] at concentrations found safe to normal cells (rat skeletal muscle cell line [L6]).

   • According to Fitsiou E (2016)

     Excerpt All essential oil preparations exhibited a variable degree of antiproliferative activity, depending on the cancer model used, with the most potent one being sweet basil against an in vitro model of human colon carcinoma. In the present study, we analyzed the composition of the volatile preparations of essential oils of the Greek plants Ocimum basilicum (sweet basil), Mentha spicata (spearmint), Pimpinella anisum (anise) & Fortunella margarita (kumquat).

   • According to Al Mofleh IA (2007)

     Excerpt Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers.

   • According to Mahboubi M (2021)

     Excerpt Mahboubi M et al, Pimpinella anisum & female disorders: A review, Phytomed Plus, 1(3) :100063, 2021-Abstract; The aim of review was to collect the previous reports on potency of aniseed in management of female disorders. There is no clinical study for anti-cancer effects of aniseed, but apoptosis can occur in human breast cancer cells in its presence.

2. 2

   Bacterial infection: Bacillus cereus, Staphylococcus aureus, Salmonella typhimurium and Escherichia coli

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Abdel-Reheem MAT (2015)

     Excerpt EO has high inhibitory effect for Salmonella typhi, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli & Micrococcus luteus. Pimpinella anisum essential oil (EO) Residual & its biotic possessions were deliberated.

   • According to Amer AM (2019)

     Excerpt The largest inhibition zones were determined to be 21.0±1.2, 18.3±1.5, 9.7±1.2, & 7.0±1.2 mm for Bacillus cereus, Staphylococcus aureus, Salmonella typhimurium, & Escherichia coli, respectively. The antioxidant & antimicrobial properties of different solvent extracts (ethanol & water) prepared from two parts (seeds & aerial parts) of Pimpinella anisum were evaluated.

   • According to Ghlissi Z (2020)

     Excerpt The polysaccharide preparation from Pimpinella anisum seeds (PAP) was isolated & characterized to evaluate its laser burn wound-healing & anti-inflammatory activities in mice. PAP showed noticeable antioxidant & antibacterial properties.

   • According to Singh G (2001)

     Excerpt The essential oils extracted from the seeds of seven spices, Anethum graveolens, Carum capticum, Coriandrum sativum, Cuminum cyminum, Foeniculum vulgare, Pimpinella anisum & Seseli indicum have been studied for antibacterial activity against eight pathogenic bacteria, causing infections in the human body.

   • According to Tepe B (2006)

     Excerpt Essential oils of the plants studied here were also screened for their antimicrobial activities against six bacteria & two fungi. & Pimpinella flabellifolia were hydro-distilled to produce oils in the yields of 2.07% (v/w) and 2.61% (v/w), respectively.

3. 3

   Inflammatory conditions: osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Conforti F (2010)

     Excerpt The ethanolic extract had significant activity with an IC (50) value of 72.7 microg/mL & this might indicate that it would have an anti-inflammatory effect in vivo. The present study shows for the first time the chemical profile & the in vitro properties (antioxidant & inhibition of nitric oxide [NO] production) of the aromatic plant Pimpinella anisoides.

   • According to Ghlissi Z (2020)

     Excerpt The polysaccharide preparation from Pimpinella anisum seeds (PAP) was isolated & characterized to evaluate its laser burn wound-healing & anti-inflammatory activities in mice. The anti-inflammatory activity of PAP in the carrageenan-induced paw edema model in mice, demonstrated by reduced edema & cellular infiltration, & oxidative stress markers in muscle tissue.

   • According to Tas A (2006)

     Excerpt Pimpinella anisum is a member of the Umbelliferae & is found in the northeastern Anatolia (Zeybek, 1960). as analgesic, anti-inflammatory, appetizing, hypnotic, antispasmodic, expectorant,.

   • According to Tabanca N (2007)

     Excerpt These findings add significant information to the pharmacological activity of Pimpinella species & their beneficial effects & use in disease prevention especially those related to inflammation. Pimpinella essential oils & isolated compounds were screened for their inhibitory activity against NF-κB mediated transcription in SW1353 cells.

   • According to Dadkhah M (2024)

     Excerpt anisum) fruit on pro-inflammatory cytokines, oxidative stress markers, & ovarian tissue structure in a rat model of PCOS. Objectives: This study evaluated the therapeutic effects of Pimpinella anisum L.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.