Piper amalago (Malenmbé) : medicinal properties in alcoholic extraction

Piper amalago (Malenmbé) — family Pipéracées.

Scientific synonyms : Piper berlandieri-C DC., P. lundelii-Trel, P. vaccinium-Standl. & Steyerm..

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 6 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 39 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   High blood pressure, fluid retention

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2014)

     Excerpt Therefore, this study aimed to evaluate the anti- inflammatory & analgesic effects of PA ethanolic extract (EEPA) & its isolated compound N-[7-(3′,4′-Methylenedioxyphenyl)-2(Z),4(Z)-hepta-dienoyl]pyrrolidine in experimental models of inflammation (paw edema & pleurisy induced by carrageenan injection), hyperalgesy (electronic von Frey), vasorelaxation (in vitro) & mean arterial pressure (MAP - in vivo), in rodents. We concluded that EEPA shows anti-inflammatory, analgesic & hypotensive properties.

   • According to Monteiro LM (2023)

     Excerpt Therefore, PA leaves are safe & present diuretic activity after acute & repeated dose administration over 7 days. is used in Brazilian traditional medicine to treat inflammation, chest pain, & anxiety.

   • According to Salehi, B (2019)

     Excerpt Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, & neuro-pharmacological activities of the extracts & extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro & in vivo studies, besides clinical studies. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver & stomach ailments, for wound healing, and as antipyretic & anti-inflammatory agents.

   • According to Stein J (2022)

     Excerpt (Piperaceae) is traditionally used due to its anti-inflammatory, analgesic, diuretic, & antiparasitic properties.

   • According to Takeara R (2017)

     Excerpt Many of these species are biologically active and have shown antitumor, antimicrobial, antioxidant, insecticidal, anti-inflammatory, antinociceptive, enzyme inhibitor, antiparasitic, antiplatelet, piscicide, allelopathic, antiophidic, anxiolytic, antidepressant, antidiabetic, hepatoprotective, amebicide & diuretic possibilities. Pharmacological studies of Piper species point toward the vast potential of these plants to treat various diseases.

2. 2

   Osteoarthritis, rheumatism, oedema

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2014)

     Excerpt Therefore, this study aimed to evaluate the anti- inflammatory & analgesic effects of PA ethanolic extract (EEPA) & its isolated compound N-[7-(3′,4′-Methylenedioxyphenyl)-2(Z),4(Z)-hepta-dienoyl]pyrrolidine in experimental models of inflammation (paw edema & pleurisy induced by carrageenan injection), hyperalgesy (electronic von Frey), vasorelaxation (in vitro) & mean arterial pressure (MAP - in vivo), in rodents. is popularly known as "pariparoba" & has been used in folk medicine as an anti-inflammatory agent, however, there is only a study that showed the topical anti- inflammatory activity for such popular use.

   • According to Salehi, B (2019)

     Excerpt Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, & neuro-pharmacological activities of the extracts & extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro & in vivo studies, besides clinical studies. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver & stomach ailments, for wound healing, and as antipyretic & anti-inflammatory agents.

   • According to Monteiro LM (2023)

     Excerpt is used in Brazilian traditional medicine to treat inflammation, chest pain, & anxiety.

   • According to Da-Silva Arrigo J (2016)

     Excerpt Piper amalago (Piperaceae) has been used in folk medicine as an analgesic. Aim of the study: This study evaluated the anti-nociceptive, anti-hyperalgesic, anti-arthritic & anti-depressive activities of the ethanolic extract of EEPA & the amides N-[7-(3',4'-methylene-dioxyphenyl)-2(Z),4(Z)-heptadienoyl] pyrrolidine (1) & N-[7-(3',4'-methylenedioxyphenyl)-2(E),4(E)-heptadienoyl] pyrrolidine (2) obtained from PA in animal models.

   • According to Stein J (2022)

     Excerpt (Piperaceae) is traditionally used due to its anti-inflammatory, analgesic, diuretic, & antiparasitic properties.

3. 3

   Pain, hyperalgesia

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Da-Silva Arrigo J (2016)

     Excerpt Piper amalago (Piperaceae) has been used in folk medicine as an analgesic. Materials & methods: Mice treated daily with EEPA (100mg/kg, p.o.) were assayed for 20 days for knee edema (micrometer measurement), mechanical hyperalgesia (analgesiometer analysis), heat sensitivity & immobility (forced swim test) in the Complete Freund's Adjuvant (CFA) model.

   • According to Monteiro LM (2023)

     Excerpt is used in Brazilian traditional medicine to treat inflammation, chest pain, & anxiety.

   • According to Giovannini P (2017)

     Excerpt Only nine species were reported in at least three studies: Cissampelos pareira L., Piper amalago L., Aristolochia trilobata L., Sansevieria Hyacinthoides (L.) Druce, Strychnos panamensis Seem., Dorstenia contrajerva L., Scoparia dulcis L., Hamelia patens Jacq., & Simaba cedron Planch. Available pharmacological data suggest different plant species may target different symptoms of snakebites, such as pain or anxiety, although more studies are needed to further evaluate the scientific basis for their use.

   • According to Author (2014)

     Excerpt Therefore, this study aimed to evaluate the anti- inflammatory & analgesic effects of PA ethanolic extract (EEPA) & its isolated compound N-[7-(3′,4′-Methylenedioxyphenyl)-2(Z),4(Z)-hepta-dienoyl]pyrrolidine in experimental models of inflammation (paw edema & pleurisy induced by carrageenan injection), hyperalgesy (electronic von Frey), vasorelaxation (in vitro) & mean arterial pressure (MAP - in vivo), in rodents. Both EEPA (100 mg/kg) & its isolated compound (3 mg/kg) exhibited antihyperalgesic effect in the model of mechanical hyperalgesia induced by carrageenan injection in mice.

   • According to Stein J (2022)

     Excerpt (Piperaceae) is traditionally used due to its anti-inflammatory, analgesic, diuretic, & antiparasitic properties.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.