Piper longum (Proof) : medicinal properties in alcoholic extraction

Piper longum (Proof, Pepper, Pwèv, Poivre) — family Pipéracées.

Scientific synonyms : Piper latifolium-WH, P Roxburghii-(Miq)-JP, P sarmentosum-Wall, P turbinatum-Bor.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 70 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Manoharan S (2007)

     Excerpt The aim of the present study was to investigate the antihyperglycemic & antilipidperoxidative effects of ethanolic extract of Piper longum dried fruits in alloxan induced diabetic rats. Piper longum (Piperaceae family) is used in Indian traditional medicine as a remedy for various disorders including diabetes mellitus.

   • According to Kumar S (2013)

     Excerpt The antidiabetic & antihyperlipidemic potential of oil from Piper longum (PLO) and piperine was investigated with their possible mechanism using α-glucosidase, aldose reductase (AR), and pancreatic lipase inhibitory activity. Results: PLO (100 & 200 mg/kg), piperine (25 & 50 mg/kg), & Glibenclamide (0.6 mg/kg) in respective groups of diabetic animals administered for 28 days reduced the blood glucose level in streptozotocin-induced diabetic rats.

   • According to Nabi SA (2013)

     Excerpt Antidiabetic & antihyperlipidemic activity of Piper longum root aqueous extract in STZ induced diabetic rats.

   • According to Takeara R (2017)

     Excerpt Many of these species are biologically active and have shown antitumor, antimicrobial, antioxidant, insecticidal, anti-inflammatory, antinociceptive, enzyme inhibitor, antiparasitic, antiplatelet, piscicide, allelopathic, antiophidic, anxiolytic, antidepressant, antidiabetic, hepatoprotective, amebicide & diuretic possibilities. Pharmacological studies of Piper species point toward the vast potential of these plants to treat various diseases.

2. 2

   Liver disorders: cirrhosis, hepatitis, fatty liver disease; normalisation of serum parameters: ALT, ASL, bilirubin, SGOT, SGPT

   Plant part used: Fruit. Mentioned synergistic association: Melia Azedarach-feuille.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Samudram P (2008)

     Excerpt Ethanolic extract from the leaves of Melia azedarach & seeds of Piper longum at a dose level of 50 mg kg-1 body weight was administered orally daily once for 14 days, prior to the administration of 0.2 mL of CCl4 kg-1 body weight for 7 days. The substantially elevated serum marker enzymes such as Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Lactate dehydrogenase (LDH), Gamma glutamyl Transferase (γGT) & 5 Nucleotidase (5NT), due to CCl4 treatment were restored towards normalization in rats pretreated with BHEE.

   • According to Gurumurthy P (2012)

     Excerpt Hepatoprotective effect of aqueous extract of Piper longum & piperine when administered with anti-tubercular drugs.

   • According to Patel JA (2009)

     Excerpt for 21 days), a significant hepatoprotective effect was observed in CCl4 induced hepatic damage as evident from decreased level of serum enzymes, total bilirubin & direct bilirubin. Piper longum (fruits & roots powder) is given with boiled milk in the Indian traditional system of medicine for the treatment of liver ailments & jaundice.

   • According to Sunila ES (2005)

     Excerpt EEPLF reduced the elevated levels of glutathione pyruvate transaminase (GPT), alkaline phosphatase (ALP), & lipid peroxidation (LPO) in liver & serum of radiation treated animals. The radioprotective property of an ethanolic extract of Piper longum fruits (EEPLF) was investigated in Swiss mice.

   • According to Shah AH (1998)

     Excerpt Acute (24 hours) & chronic (90 days) oral toxicity studies on the ethanolic extracts of common spices Cinnamomum zeylanicum bark & Piper longum fruits were carried out in mice. longum caused a significant increase in the weight of the lungs & spleen of the treated animals compared to the control.

3. 3

   Cancer: adjuvant treatment for leukaemia, breast, colorectal and ovarian cancer, pancreatic cancer, lymphoma and melanoma

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sunila ES (2004)

     Excerpt Alcoholic extract of the fruits of the plant Piper longum & its component piperine was studied for their immunomodulatory & antitumor activity. Administration of alcoholic extract of PL (10 mg/dose/animal) as well as piperine (1.14 mg/dose/animal) could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor to 37.3 & 58.8%, respectively.

   • According to Mitra S (2024)

     Excerpt The most frequently caused malignancy in women globally, breast cancer (BC), has been demonstrated to be significantly inhibited by PL. Piperlongumine (PL), an alkaloid found primarily in the fruits & roots of the plant Piper longum L.

   • According to Urolagin DK (2018)

     Excerpt Here, we investigated the anti-cancer effects of 3 drug extracts-Vitis vinifera-Grape seeds (GSE), Ixora coccinea flower & Piper longum root extract against breast cancer treatment. The aim of present work is to find out the invitro cytotoxic effect of the constituents of polyherbal extract on MCF-7 human breast cancer cells.

   • According to Ovadje P (2014)

     Excerpt To scientifically assess & validate the anticancer potential of an ethanolic extract of the fruit of the long pepper (PLX), a plant of the piperaceae family that has been used in traditional medicine, especially Ayurveda & investigate the anticancer mechanism of action of PLX against cancer cells. Results : Our results indicated that an ethanolic long pepper extract selectively induces caspase-independent apoptosis in cancer cells, without affecting non-cancerous cells, by targeting the mitochondria, leading to dissipation of the mitochondrial membrane potential & increase in ROS production.

   • According to Park JA (2019)

     Excerpt Piperlongumine (PL), a natural alkaloid compound isolated from long pepper (Piper longum), can selectively kill cancer cells, but not normal cells, by accumulation of reactive oxygen species (ROS). PARP cleavage & positive annexin V level were increased during PL treatment with FosB overexpression whereas PARP cleavage & positive annexin V level were decreased during PL treatment with siFosB transfection, implying that FosB might be a proapoptotic protein for induction of cell death in PL-treated MCF7 breast cancer cells.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.