Piper nigrum (Pwèv-nwè) : medicinal properties in alcoholic extraction

Piper nigrum (Pwèv-nwè, Black pepper, Poivre noir) — family Piperacées.

Scientific synonyms : Muldera multinrervis-Miq.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 25 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 93 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to ONYESIFE C O (2014)

     Excerpt The effect of ethanol leaves extracts of Piper nigrum on some biochemical parameters in alloxan induced diabetic rats, was carried out. The result of this study indicates that ethanol leaves extract of Piper nigrum has hypoglycemic tendencies in diabetic conditions.

   • According to Kaleem M (2005)

     Excerpt Kaleem M et al, Protective effects of Piper nigrum & Vinca rosea in alloxan induced diabetic rats.

   • According to Takeara R (2017)

     Excerpt Many of these species are biologically active and have shown antitumor, antimicrobial, antioxidant, insecticidal, anti-inflammatory, antinociceptive, enzyme inhibitor, antiparasitic, antiplatelet, piscicide, allelopathic, antiophidic, anxiolytic, antidepressant, antidiabetic, hepatoprotective, amebicide & diuretic possibilities. Pharmacological studies of Piper species point toward the vast potential of these plants to treat various diseases.

2. 2

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bai XP (2011)

     Excerpt The findings indicate that the ethanol extract of PN root is an efficient hepatoprotective & antioxidant agent against 4-CCl-induced liver injury,. The aim of this study was to investigate the effect of Piper nigrum L.

   • According to Patel JA (2009)

     Excerpt Hepatoprotective activity of Piper longum traditional Milk extract on carbon tetrachloride induced liver toxicity in Wistar rats.

   • According to Kavitha M (2011)

     Excerpt Ethanolic extract from the leaves of Melia Azadirachta, seeds of Piper longum & whole plant of Eclipta alba at a dose level of 50 mg/kg body weight was administered orally daily once for 14 days. The Poly-herbal ethanolic extract (PHEE) was evaluated for its anti-hepatotoxic potential against carbon tetrachloride (CCL 4) induced hepatic damage in male albino rats.

   • According to PANDA S (2003)

     Excerpt An investigation was made to evaluate the effects of water & ethanol extracts of Piper nigrum L. Rather, the latter extract appeared to be antithyroidic & antiperoxidative in nature as it could decrease serum thyroid hormone concentrations & hepatic lipid peroxidation, respectively.

   • According to Gupta RA (2015)

     Excerpt & Piper nigrum Linn., is a plant alkaloid with a long history of medicinal use. Piperine exhibits antidepressant, hepatoprotective, antimetastatic, antithyroid, immunomodulatory, antitumor & anti-inflammatory activities, however its therapeutic potential in amelioration of ulcerative colitis & the underlying mechanism for anti-inflammatory activity remains unknown.

3. 3

   Rheumatoid arthritis

   Plant part used: Fruit. Mentioned synergistic association: Curcuma longa-Rhiz, association synergique avec VITEX NEGUNDO-L (Feuille), Zingiber officinale-Rhiz.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to KHARAT SS (2024)

     Excerpt This project aims to develop a polyherbal emulgel, a topical formulation, utilizing the synergistic effects of Vitex negundo (leaves), Curcuma longa (Rhizoma), Piper nigrum (fruit), & Zingiber officinale (rhizoma), known for their anti-inflammatory, analgesic, & antioxidant properties. Vitex negundo (Nirgundi) possesses anti-inflammatory & analgesic properties, while Curcuma longa (Turmeric) is known for its potent anti-inflammatory & antioxidant effects.

   • According to Pratibha N (2004)

     Excerpt A novel, safe polyherbal formulation (Aller-7/NR-A2) has been developed for the treatment of allergic rhinitis using a unique combination of extracts from seven medicinal plants including Phyllanthus Emblica, Terminalia chebula, Terminalia bellerica, Albizia lebbeck, Piper nigrum, Zingiber officinale & Piper longum. Aller-7 also exhibited a dose-dependent (150-350 mg/kg) anti-inflammatory effect against Freund's adjuvant-induced arthritis in Wistar Albino rats & an approximately 63% inhibitory effect was observed at a dose of 350 mg/kg.

   • According to Tasleem F (2014)

     Excerpt To evaluate & compare the analgesic & anti-inflammatory activity of pure compound, piperine along with hexane & ethanol extracts of Piper nigrum fruit in mice & rats. While the anti-inflammatory activity was evaluated by carrageenan-induced paw inflammation in rats.

   • According to Salehi, B (2019)

     Excerpt Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, & neuro-pharmacological activities of the extracts & extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro & in vivo studies, besides clinical studies. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver & stomach ailments, for wound healing, and as antipyretic & anti-inflammatory agents.

   • According to PRASAD K (2015)

     Excerpt The result showed a higher stabilization potential in ethanolic extract of Piper nigrum seeds which showed 55.17±1.56, 64.00±1.18 & 70.50±0.96 percentage inhibition of mast cell degranulation. In the present study a comparative effect of mast cell stabilizing activity of different plant extracts Momordica dioica fruit pulp (family-Cucurbitaceae), Cuminum cyminum seeds (family - Apiaceae), Piper nigrum seeds (family-Piperaceae), Boerhaavia diffusa roots (family - Nyctaginaceae.), Withania somnifera roots (family-Solanaceae), Mangifera indica leaves (Anacardiaceae), Plantago ovata (Plantaginaceae) was carried out.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.