Plectranthus amboinicus (Gwo-diten) : medicinal properties in alcoholic extraction

Plectranthus amboinicus (Gwo-diten, Large thyme, Gros-thym) — family Lamiacées.

Scientific synonyms : Coleus amboinicus-Lour., C aromaticus-Benth..

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 23 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 75 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: Aeromonas hydrophila, Edverchila tarda, Enterobacter aerogenes, Flavobacterium, Escherichia coli, Proteus mirabilis, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to MUNIANDY K (2014)

     Excerpt aromaticus demonstrated good antibacterial activity against Escherichia coli, Proteus mirabilis & Staphylococcus aureus & moderate activity against Pseudomonas aeruginosa & Klebsiella pneumonia. This antibacterial study indicates the crude extract as a bioactive compound that could be useful to develop new antimicrobial agents & it can be used to assist us in reducing the burden of cost & drug resistance.

   • According to Author (2016)

     Excerpt or Plectranthus amboinicus Lour. This article is an effort to compile the information reported on its antimicrobial activities.

   • According to Nirmala D (2008)

     Excerpt amboinicus has antimicrobial & antifungal activity. Further investigation in the isolation & purification of the active principle responsible for the activity may provide an antimicrobial, antifungal along with antileptospiral activity drug Template from natural source.

   • According to Author (1998)

     Excerpt Rasmi A, Antiviral activity against Herpès Simplex Virus type 2 of extracts from Cerbera odollam Gaertn., Clausena excavata Burm. F., Coleus amboinicus Lour., Phyla nodiflora (L.) Greene & Thevetia peruviana Schum, MSc.

   • According to Dos Santos NO (2015)

     Excerpt Dos Santos NO et al, Assessing the chemical composition & antimicrobial activity of essential oils from Brazilian plants—Eremanthus erythropappus (Asteraceae), Plectranthus barbatus, & P.

2. 2

   Cancer: adjuvant treatment for sarcoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Gurgel AP (2009)

     Excerpt Plectranthus amboinicus (Lour.) Spreng is a medicinal specie often used in Brazil, especially in Northeast Region, for the treatment of several diseases including inflammations and cancer. amboinicus at the doses of 100, 150, 250 & 350 mg/kg (i.p.) inhibited the growth of sarcoma-180 & Ehrlich Ascite carcinoma tumors in mice.

   • According to Hasibuan PAZ (2019)

     Excerpt Conclusions: The P amboinicus leaves Ethanolic Extract Nanoparticles could be an effective anticancer by improving its downregulation on cyclinD1, upregulation caspase-9 & p53. The application of nanotechnology is aimed to enhance the capability of the chemical compounds of Plectranthus amboinicus leaves activity.

   • According to Manurung K (2020)

     Excerpt Conclusions : All the flavonoid compounds contained in the ethanolic extract of P amboinicus leaves exhibit very strong anti-cancer & antioxidant activity, which results in ethanolic extract of P amboinicus leaves have very strong antioxidant activity. The results showed that the flavonoid compounds contained in P amboinicus have similar anticancer activity to the reference molecule at the P-Glycoprotein-1, Cyclin Dependent Kinase-2, & Phosphoinositide-3-Kinase receptors, as well as better anticancer activity than the reference molecule for the Cyclooxygenase-2 & Phosphoenolpyruvate Carboxykinase receptors.

   • According to Hasibuan PAZ (2017)

     Excerpt Results: Treatment with P amboinicus (ethanolic extract nanoparticles (PAEEN) inhibited the proliferation of T47D cell lines after 48 hours & 72 hours of incubation at concentrations of 22.3 μg/mL, 44.6 μg/mL, & 89.2 μg/mL. Plectranthus amboinicus (Lour.) Spreng.

   • According to Leo caroline M (2022)

     Excerpt Studies show that the two medicinal herbs Plectranthus amboinicus (Indian borage, Karpooravalli) & Glycyrrhiza glabra (Liquorice, Athimathuram) have shown excellent anticancer activity on various cancers. The present study aimed to evaluate & assess the anticancer property of two medicinal plants PA & GG on oral cancer (KB) cell line.Materials & Methods: Ethanolic extracts of leaves of PA & roots of GG were prepared.

3. 3

   Viral infection: herpes simplex

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (1998)

     Excerpt Rasmi A, Antiviral activity against Herpès Simplex Virus type 2 of extracts from Cerbera odollam Gaertn., Clausena excavata Burm. F., Coleus amboinicus Lour., Phyla nodiflora (L.) Greene & Thevetia peruviana Schum, MSc.

   • According to Author (2016)

     Excerpt or Plectranthus amboinicus Lour. This article is an effort to compile the information reported on its antimicrobial activities.

   • According to Nirmala D (2008)

     Excerpt amboinicus has antimicrobial & antifungal activity. Further investigation in the isolation & purification of the active principle responsible for the activity may provide an antimicrobial, antifungal along with antileptospiral activity drug Template from natural source.

   • According to Dos Santos NO (2015)

     Excerpt Dos Santos NO et al, Assessing the chemical composition & antimicrobial activity of essential oils from Brazilian plants—Eremanthus erythropappus (Asteraceae), Plectranthus barbatus, & P.

   • According to Ragasa CY (1999)

     Excerpt Antimicrobial flavones from Coleus amboinicus.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.