Plumbago scandens (Moutad-péyi) : medicinal properties in alcoholic extraction

Plumbago scandens (Moutad-péyi, Country mustard, Moutarde pays) — family Plumbaginacées.

Scientific synonyms : Plumbago floridana-Nutt, P. mexicana-Kunth in HBK, P. occidentalis-Sweet, P Zeylanica-Linn.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 28 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 131 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Olagunju JA (1999)

     Excerpt he effects of the ethanol extract of the root of Plumbago zeylanica on key enzymes of glycolysis & other biochemical parameters were studied in the rat. This may be a result of impaired delivery to & utilization of, glucose by the peripheral tissue, thus substantiating the reported hyperglycaemia in the extract‐treated rats.

   • According to Olagunju JA (2000)

     Excerpt The ethanolic root extract of Plumbago zeylanica was investigated for induction of hyperglycaemia in the rat. The increased activity of AST may also enhance the synthesis of oxaloacetate & consequently citrate, both of which inhibit phosphofructokinase activity, thus decreasing glycolytic flux, glucose uptake & utilization by the glycolytic pathway & possibly contributing to the observed hyperglycemia in rats treated with PZ.

   • According to Zarmouh MM (2010)

     Excerpt This paper reports the results of oral administration of root extract of Plumbago zeylanica on blood glucose & plasma antioxidant status in streptozotocin (STZ) diabetic rats. The PZ root extract is hypoglycemic, hepatoprotective & is able to ameliorate biochemical damages in Streptozotocin induced diabetic rats.

   • According to Tyagi R (2023)

     Excerpt The in vitro antidiabetic, antioxidant studies expressed the protective effect from oxidative stress, CLSM of rat’s intestine ability to penetrate to great extent & could be a promising candidate for the management of diabetes mellitus,. This study aimed to develop and evaluate a niosomal formulation loaded with Plumbago zeylanica extract (PZE).

   • According to Kumar G (2007)

     Excerpt on blood glucose & plasma antioxidant status in STZ diabetic rats.

2. 2

   Cancer: adjuvant treatment of anal, pancreatic, lung and liver (hepatocellular) carcinoma

   Plant part used: root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Akhilraj AR (2021)

     Excerpt Results :The results showed the elevated concentration of biochemical markers and histopathological degenerative changes in animals treated with paracetamol indicating severe hepatic damage; whereas, the treatment with decoction of both the species of Citraka showed significant reduction in the serum markers & regenerative changes in the histopathological specimens pointing towards its effectiveness as a hepatoprotective drug. Objective(s) :The aim of the study was to experimentally evaluate the comparative effect of hepatoprotective activity of detoxified root decoction of the two species of Citraka against paracetamol-induced hepatotoxicity in male Wistar albino rats.

   • According to Goyal R (2012)

     Excerpt The present study was designed to investigate the hepatoprotective effects of standardized methanolic extract of PZaroot on paracetamol, CCl4 & alcohol induced hepatic injuries in rats & its possible mechanism(s) of hepatoprotection. The results in present study suggested that PZ root possesses marked hepatoprotective potential through its oxidative, inflammatory & fibrotic effects against experimentally induced liver toxicity.

   • According to Zarmouh MM (2010)

     Excerpt Oral administration of ethanolic extract (100, 200 mg/kg) in streptozotocin diabetic rats increased hepatic hexokinase activity & decreased hepatic glucose-6-phosphatase, serum acid phosphatase (ACP), alkaline phosphatase (ALP) & lactate dehydrogenase (LDH). This paper reports the results of oral administration of root extract of Plumbago zeylanica on blood glucose & plasma antioxidant status in streptozotocin (STZ) diabetic rats.

   • According to Kumar R (2009)

     Excerpt Kumar R et al, HEPATOPROTECTIVE ACTIVITY OF AERIAL PARTS OF PLUMBAGO ZEYLANICA LINN AGAINST CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS, Inter J of Pharm & Pharmaceut Sci, 1, Suppl 1: 2009.

   • According to Hafeez BB (2012)

     Excerpt In addition, i.p administration of PL (2 mg/kg body weight, 5 days a week) in SCID mice beginning 3 days after ectopic implantation of PANC1 cells resulted in a significant (P<0.01) inhibition of both tumor weight and volume. We present here that plumbagin (PL), a quinoid constituent isolated from the roots of the medicinal plant Plumbago zeylanica, inhibits the growth of PC cells both in vitro & in vivo model systems.

3. 3

   Bacterial infection: Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio cholerae

   Plant part used: root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hoffmann JJ (1993)

     Excerpt The dichlorométhane extract of Guardiola platyphylla & ethanol extracts of Plumbago scandens, Acacia angustissima & Salvia sonomensis demonstrated the best spectrum of activity by completely inhibiting the growth of Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae & Candida albicans. subtilis proved to be very susceptible with 188 species either completely inhibiting or slowing the growth of this gram-positive organism.

   • According to Rahman S (2007)

     Excerpt The extract was also very effective against Escherichia coli & Pseudomonas aeruginosa showing MIC value of 250 μ μμ μμg/ml. Among the test bacteria, Vibrio cholerae was found to be the most sensitive to the extract showing the highest diameter of zone of inhibition & lowest minimum inhibitory concentration (MIC) value (200 μ μμ μμg/ml).

   • According to AZ B (2000)

     Excerpt Alcoholic extract of Plumbago zeylanica (root) was tested against multidrug-resistant clinical isolates of bacteria (Salmonella paratyphi, Staphylococcus aureus, Escherichia coli, Shigella dysenteriae & a R-plasmid-harbouring standard strain, E.coli x+). coli x+ (p UK 651) by the plant extract, DNA intercalating dyes (acridine orange & ethidium bromide) & a DNA gyrase antagonizing drug (Pefloxacine) were made.

   • According to Tharmaraj RS (2015)

     Excerpt For the Bioefficacy studies six different extracts of Plumbago species with various concentrations viz., 20, 40, 60, 80& 100μg/ml against gram positive & gram-negative bacterial pathogens viz., Staphylococcus aureus (MTCC 737), Streptococcus pyogenes (MTCC 1928), Bacillus subtilis (MTCC 441), Klebsiella pneumoniae (MTCC 109), Morganella morganii (MTCC 662) & Pseudomonas aeruginosa (MTCC 1688) using well diffusion method. The ethanolic extract of all the Plumbago species revealed superior bactericidal activity compared to other tested extracts.

   • According to Abera A (2015)

     Excerpt The main objective of this study was to investigate the antioxidant & antimicrobial activities of the crude extract of Plumbago zeylanica root. coli (clinical) (gram negative bacteria) & antifungal activity against C.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.