Plumbago scandens (Moutad-péyi) : vertus médicinales en extraction alcoolique

Plumbago scandens (Moutad-péyi, Moutarde pays) — famille Plumbaginacées.

Synonymes scientifiques : Plumbago floridana-Nutt, P. mexicana-Kunth in HBK, P. occidentalis-Sweet, P Zeylanica-Linn.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 28 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 131 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Olagunju JA (1999)

     Extrait he effects of the ethanol extract of the root of Plumbago zeylanica on key enzymes of glycolysis & other biochemical parameters were studied in the rat. This may be a result of impaired delivery to & utilization of, glucose by the peripheral tissue, thus substantiating the reported hyperglycaemia in the extract‐treated rats.

   • Selon Olagunju JA (2000)

     Extrait The ethanolic root extract of Plumbago zeylanica was investigated for induction of hyperglycaemia in the rat. The increased activity of AST may also enhance the synthesis of oxaloacetate & consequently citrate, both of which inhibit phosphofructokinase activity, thus decreasing glycolytic flux, glucose uptake & utilization by the glycolytic pathway & possibly contributing to the observed hyperglycemia in rats treated with PZ.

   • Selon Zarmouh MM (2010)

     Extrait This paper reports the results of oral administration of root extract of Plumbago zeylanica on blood glucose & plasma antioxidant status in streptozotocin (STZ) diabetic rats. The PZ root extract is hypoglycemic, hepatoprotective & is able to ameliorate biochemical damages in Streptozotocin induced diabetic rats.

   • Selon Tyagi R (2023)

     Extrait The in vitro antidiabetic, antioxidant studies expressed the protective effect from oxidative stress, CLSM of rat’s intestine ability to penetrate to great extent & could be a promising candidate for the management of diabetes mellitus,. This study aimed to develop and evaluate a niosomal formulation loaded with Plumbago zeylanica extract (PZE).

   • Selon Kumar G (2007)

     Extrait on blood glucose & plasma antioxidant status in STZ diabetic rats.

2. 2

   Cancer : traitement adjuvant du carcinome anal, pancréatique, pulmonaire et hépatique (hépatome)

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Akhilraj AR (2021)

     Extrait Results :The results showed the elevated concentration of biochemical markers and histopathological degenerative changes in animals treated with paracetamol indicating severe hepatic damage; whereas, the treatment with decoction of both the species of Citraka showed significant reduction in the serum markers & regenerative changes in the histopathological specimens pointing towards its effectiveness as a hepatoprotective drug. Objective(s) :The aim of the study was to experimentally evaluate the comparative effect of hepatoprotective activity of detoxified root decoction of the two species of Citraka against paracetamol-induced hepatotoxicity in male Wistar albino rats.

   • Selon Goyal R (2012)

     Extrait The present study was designed to investigate the hepatoprotective effects of standardized methanolic extract of PZaroot on paracetamol, CCl4 & alcohol induced hepatic injuries in rats & its possible mechanism(s) of hepatoprotection. The results in present study suggested that PZ root possesses marked hepatoprotective potential through its oxidative, inflammatory & fibrotic effects against experimentally induced liver toxicity.

   • Selon Zarmouh MM (2010)

     Extrait Oral administration of ethanolic extract (100, 200 mg/kg) in streptozotocin diabetic rats increased hepatic hexokinase activity & decreased hepatic glucose-6-phosphatase, serum acid phosphatase (ACP), alkaline phosphatase (ALP) & lactate dehydrogenase (LDH). This paper reports the results of oral administration of root extract of Plumbago zeylanica on blood glucose & plasma antioxidant status in streptozotocin (STZ) diabetic rats.

   • Selon Kumar R (2009)

     Extrait Kumar R et al, HEPATOPROTECTIVE ACTIVITY OF AERIAL PARTS OF PLUMBAGO ZEYLANICA LINN AGAINST CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS, Inter J of Pharm & Pharmaceut Sci, 1, Suppl 1: 2009.

   • Selon Hafeez BB (2012)

     Extrait In addition, i.p administration of PL (2 mg/kg body weight, 5 days a week) in SCID mice beginning 3 days after ectopic implantation of PANC1 cells resulted in a significant (P<0.01) inhibition of both tumor weight and volume. We present here that plumbagin (PL), a quinoid constituent isolated from the roots of the medicinal plant Plumbago zeylanica, inhibits the growth of PC cells both in vitro & in vivo model systems.

3. 3

   Infection bacterienne : Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio cholera

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Hoffmann JJ (1993)

     Extrait The dichlorométhane extract of Guardiola platyphylla & ethanol extracts of Plumbago scandens, Acacia angustissima & Salvia sonomensis demonstrated the best spectrum of activity by completely inhibiting the growth of Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae & Candida albicans. subtilis proved to be very susceptible with 188 species either completely inhibiting or slowing the growth of this gram-positive organism.

   • Selon Rahman S (2007)

     Extrait The extract was also very effective against Escherichia coli & Pseudomonas aeruginosa showing MIC value of 250 μ μμ μμg/ml. Ethanolic extract of Plumbago zeylanica root was investigated for its antimicrobial activities against 11 human pathogenic bacteria & 6 phytopathogenic fungi using disc diffusion method & poisoned food technique respectively.

   • Selon AZ B (2000)

     Extrait Alcoholic extract of Plumbago zeylanica (root) was tested against multidrug-resistant clinical isolates of bacteria (Salmonella paratyphi, Staphylococcus aureus, Escherichia coli, Shigella dysenteriae & a R-plasmid-harbouring standard strain, E.coli x+). coli x+ (p UK 651) by the plant extract, DNA intercalating dyes (acridine orange & ethidium bromide) & a DNA gyrase antagonizing drug (Pefloxacine) were made.

   • Selon Tharmaraj RS (2015)

     Extrait For the Bioefficacy studies six different extracts of Plumbago species with various concentrations viz., 20, 40, 60, 80& 100μg/ml against gram positive & gram-negative bacterial pathogens viz., Staphylococcus aureus (MTCC 737), Streptococcus pyogenes (MTCC 1928), Bacillus subtilis (MTCC 441), Klebsiella pneumoniae (MTCC 109), Morganella morganii (MTCC 662) & Pseudomonas aeruginosa (MTCC 1688) using well diffusion method. The ethanolic extract of all the Plumbago species revealed superior bactericidal activity compared to other tested extracts.

   • Selon Abera A (2015)

     Extrait The main objective of this study was to investigate the antioxidant & antimicrobial activities of the crude extract of Plumbago zeylanica root. coli (clinical) (gram negative bacteria) & antifungal activity against C.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.