Plumeria rubra (Red frangipani) : medicinal properties in alcoholic extraction

Plumeria rubra (Red frangipani, Franjipanié wouj, Frangipanier rouge) — family Apocynacées.

Scientific synonyms : -----.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 19 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Muruganantham S (2014)

     Excerpt The present study has been performed experimentally by in vitro method to examine the anti-cancer activity of various concentrations of ethanolic extract of flowers of Plumeria rubra. The ethanolic extract of flowers of PR was tested for its anti-cancer activity against liver cancer HePG2 cell line by MTT assay.

   • According to Bihani T (2021)

     Excerpt The plant possesses a wide range of pharmacological activities present namely antibacterial, antiviral, anti-inflammatory, antipyretic, antidiabetic, hepatoprotective, anticancer, anthelmintic, antifertility & many other activities. (Apocynaceae) is a deciduous, commonly ornamental, tropical plant grown in home premises, parks, gardens, graveyards, because of its beautiful & attractive flowers of various colors & size.

   • According to Rahman H (2014)

     Excerpt Plumeria species could be a new source of drugs for the treatment of colon cancer & hyperlipidemic conditions due to higher antioxidant potential & phenolic content which was revealed from the study. DPPH assay of methanolic extract of Plumeria revealed that 81% & 72% inhibition by PA & PR respectively & the total phenolic content was found as 173.9 µg ml-1 & 167.3 µg ml-1.

   • According to Banu-Rekha J (2011)

     Excerpt .The ethanolic extract of leaves of Plumeria rubra (Linn) were evaluated for their anti cancer activity against Ehrlich Ascites Carcinoma (EAC) in Swiss albino mice. The anti cancer activity of PR was examined by determining the tumor volume, tumor cell count, viable tumor cell count, non viable tumor cell count, mean survival time & increase in life span in experimental animal models.

   • According to Muhtadi M (2021)

     Excerpt rubra flowers with an IC50 value of 150, 20 ppm while in the FRAP method the highest activity was in P. This study aims to determine the antioxidant activity of Plumeria alba L & Plumeria rubra L.

2. 2

   Type II diabetes mellitus

   Plant part used: flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ahmed AS (2017)

     Excerpt (Piperaceae) & flowers of Plumeria rubra L. Inhibition of intestinal α-amylase and α-glucosidase is an important strategy to regulate diabetes mellitus (DM).

   • According to Zhang SN (2020)

     Excerpt A decoction of Plumeria rubra flowers has been used traditionally for the treatment of diabetes in China & Mexico. Chemical investigations on the bioactive constituents of these flowers led to the isolation of 30 compounds, including the four new compounds, one iridoiod (1), two triterpenoids (4, 5), & a long-chain δ-lactone (16).

   • According to Yadav AV (2022)

     Excerpt the current investigation analysed the effect of combination of standardized hydroalcoholic extracts of Asparagus racemosus (AR), Centella asiatica (CA) & Plumeria rubra (PR) on glibenclamide (GB) administered in experimentally induced diabetic nephropathy (DN) in Wistar rats. Co-administration of ACP (400mg/kg) with GB (5mg/kg) significantly (p<0.01) decreased BUN, creatinine, uric acid, significantly increased (p<0.05) SOD, significantly (p<0.01) decreased MDA, significantly increased (p<0.05) serum insulin when compared with diabetic control.

   • According to Merina A (2019)

     Excerpt Antioxidant & hypolipidemic activity of the flovone glycoside isolated from Plumeria rubra was carried in alloxan induced hyperglycemic rats.

   • According to Bihani T (2021)

     Excerpt The different parts of the plant are used traditionally to treat various diseases & conditions like leprosy, inflammation, diabetic mellitus, ulcers, wounds, itching, acne, toothache, earache, tongue cleaning, pain, asthma, constipation & antifertility. The plant possesses a wide range of pharmacological activities present namely antibacterial, antiviral, anti-inflammatory, antipyretic, antidiabetic, hepatoprotective, anticancer, anthelmintic, antifertility & many other activities.

3. 3

   Oxidative stress

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ahmed AS (2017)

     Excerpt Hence, methanol & aqueous extracts of the aforementioned plants were evaluated for their in vitro α-glucosidase and α-amylase inhibition at 1 mg/mL & quantification of their antioxidant properties (DPPH, FRAP tests, total phenolic & total flavonoids contents). rubra were 10.41 (0.03), 95.19 (0.01), & -2.92 (0.03), while the methanol extracts exhibited % inhibition 13.73 (0.02), 92.77 (0.01), & -0.98 (0.01), respectively.

   • According to Muhtadi M (2021)

     Excerpt This study aims to determine the antioxidant activity of Plumeria alba L & Plumeria rubra L. rubra leaves with an antioxidant activity value of 79.75 mg AAE / g extract.

   • According to Merina A (2019)

     Excerpt Antioxidant & hypolipidemic activity of the flovone glycoside isolated from Plumeria rubra was carried in alloxan induced hyperglycemic rats. Antioxidant activity of the drug was also confirmed through in vitro studies.

   • According to Yadav AV (2022)

     Excerpt the current investigation analysed the effect of combination of standardized hydroalcoholic extracts of Asparagus racemosus (AR), Centella asiatica (CA) & Plumeria rubra (PR) on glibenclamide (GB) administered in experimentally induced diabetic nephropathy (DN) in Wistar rats. Results: ACP along with GB improved the derailed glycaemic status, renal biochemical, oxidative stress parameters in animals.

   • According to Rahman H (2014)

     Excerpt Plumeria species could be a new source of drugs for the treatment of colon cancer & hyperlipidemic conditions due to higher antioxidant potential & phenolic content which was revealed from the study. rubra were tested for in vitro antioxidant potential, cytotoxicity & hypolipidemic activities.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.