Pongamia pinnata (Karanja) : medicinal properties in alcoholic extraction

Pongamia pinnata (Karanja) — family Fabacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 6 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 26 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Inflammatory conditions: osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Srinivasan K (2001)

     Excerpt In the present study, the anti-inflammatory activity of 70% ethanolic extract of Pongamia pinnata leaves (PLE) in acute, subacute & chronic models of inflammation was assessed in rats. Per os (p.o.) administration of PLE (300, 1000 mg/kg) exhibited significant anti-inflammatory activity in acute (carrageenin, histamine, 5-hydroxytryptamine & prostaglandin E2-induced hind paw edema), subacute (kaolin-carrageenin & formaldehyde-induced hind paw edema) & chronic (cotton pellet granuloma) models of inflammation.

   • According to YASOTHKUMAR D (2023)

     Excerpt Pongamia pinnata Merr., a member of the Fabaceae family, is extensively spread throughout tropical Asia. The anti-oxidant & anti-inflammatory activity of PP seed extract was considerably higher at 500 g, as shown by the DPPH test & albumin denaturation inhibition.

   • According to DONG H (2022)

     Excerpt The anti-inflammatory activities of compounds 1-3, as well as their aglycones 5a, 5b, & 23, were determined against NO production in the LPS-stimulated RAW264.7 cells. The results indicated that the O-glycosylation may reduce the anti-inflammatory activity of furano Flavonoid in vitro.

   • According to Dwivedi D (2016)

     Excerpt pinnata leaf were studied for wound healing efficiency, & was assessed by the rate of wound contraction, tensile strength, breaking strength, hydroxyproline & hexosamine content, along with its effect on pro-inflammatory & anti-inflammatory cytokines was assessed using excision & incision model of wound repair in Wistar rats. to investigate wound healing, antimicrobial & antioxidant activity of leaf extract of Pongamia Pinnata.

   • According to DHAR R (2026)

     Excerpt Pongamia pinnata (L.) Pierre (P. Furthermore, flavonoid & other bioactive compounds derived from PP serve anti‐inflammatory, anti‐metastasis activities, and induce apoptosis.

2. 2

   Type II diabetes mellitus

   Plant part used: stem bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Badole S.L (2008)

     Excerpt Pongamia pinnata (L.) Pierre (Fabaceae), popularly known as “Karanj” or “Karanja” in Hindi, & Indian beech in English, is a medium-sized glabrous tree. In the present study we report the antihyperglycemic activity of stem bark of alcohol extract of Pongamia pinnata (PPSBAE).

   • According to JEELANI I (2023)

     Excerpt Pongamia pinnata (L) is one of many plants which possess various medicinal properties, & its chemical constituents have been used for the prevention & treatment of various human diseases in many countries as traditional medicine. Pongamia pinnata (P.

3. 3

   Malaria: Plasmodium falciparum

   Plant part used: Pesticidal and veterinary use.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Simonsen HT (2001)

     Excerpt The following five species seems to be of special interest for further antimalarial studies, Casearia elliptica, Holarrhena pubescens, Pongamia pinnata, Soymida febrifuga & Plumbago zeylanica. Plants traditionally used in India to treat fever or malaria were examined in vitro for antiplasmodial properties against Plasmodium falciparum.

   • According to SATISH PPP (2017)

     Excerpt The objective of the current study was to assess the in vitro antiplasmodial activities of leaf, bark, flower, & the root of Pongamia pinnata against chloroquine-sensitive Plasmodium falciparum (3D7 strain), cytotoxicity against Brine shrimp larvae & THP-1 cell line. Sequentially crude extracts of methanol (polar), chloroform (non-polar), hexane (non-polar), ethyl acetate (non-polar) & aqueous (polar) of dried leaves, bark, flowers & roots of Pongamia pinnata were prepared using Soxhlet apparatus.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.