Portulaca oleracea (Koupié) : medicinal properties in alcoholic extraction

Portulaca oleracea (Koupié, Poupié, Purslane, Pourpier) — family Portulacacées.

Scientific synonyms : Portulaca oleracea var. Parviflora-(Haw)-Griseb, P. Oleracea var. Parviflora. Griseb, P. Parviflora-Haw, P Parviflora var. macrantha-Eggers, P. Oleracea var. micrantha. Eggers.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 28 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 101 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hepatotoxicity: non-alcoholic fatty liver disease, caused by paracetamol (Doliprane)

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Liu XF (2015)

     Excerpt Acetaminophen-induced liver injury represents the most frequent cause of drug-induced liver failure in the world. The results demonstrated that PO was an effective anti-oxidative agent, which could, to some extent, reverse APAP-induced hepatotoxicity by regulating the reactive oxygen species (ROS) in the liver of mice.

   • According to Damavandi RD (2021)

     Excerpt At the end of study, no significant changes were observed in liver steatosis grade, insulin, liver enzymes, total bilirubin, lipid profile, & blood pressure between the two groups. The aim of the present study was to examine the effect of PO hydroalcoholic extract in patients with non-alcoholic fatty liver disease (NAFLD).

   • According to Milkarizi N (2024)

     Excerpt Portulaca oleracea exhibit antioxidant, anti-inflammatory, & hepatoprotective effects. Liver steatosis & fibrosis were assessed using elastography along with liver function & metabolic tests, blood pressure measurements, body composition analysis & dietary records pre-& post-intervention.

   • According to Shi H (2014)

     Excerpt In present study, carbon tetrachloride (CCl4) was used to induce acute liver damage in mice & the protective effects of ethanol extract of Portulaca Oleracea (PO) were examined. In addition, in cultured hepatic cells, PO increased the NF-κB luciferase reporter gene activity and upregulated the level of phosphorylation of p65, but had no effects on mice liver SOD activity & MDA level.

   • According to Shi H (2014)

     Excerpt In present study, carbon tetrachloride (CCl4) was used to induce acute liver damage in mice & the protective effects of ethanol extract of Portulaca Oleracea L. In addition, in cultured hepatic cells, PO increased the NF-κB luciferase reporter gene activity and upregulated the level of phosphorylation of p65, but had no effects on mice liver SOD activity & MDA level.

2. 2

   Type 1 diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Damavandi RD (2021)

     Excerpt Purslane (Portulaca oleracea L.) is the richest green leafy vegetable source of omega-3, especially alpha linolenic acid (ALA). Compared with baseline, alanine aminotransferase (ALT) (-9 [-17, 0.50] mg/dl; p = .007), aspartate aminotransferase (AST) (-4 [-10, -0.50] mg/dl; p = .001), gamma glutamyl transferase (GGT) (-6.21 ± 9.85 mg/dL; p < .001), fasting blood glucose (FBG) (-8 [-11, -1.50] mg/dl; p < .001) insulin resistance (-0.95 ± 2.23; p = .020), triglyceride (-20 [-67.50, 3.50] mg/dl; p = .010), & low-density lipoprotein cholesterol (LDL-C) (-5 [-12, -1] mg/dl; p < .001) decreased significantly in the PO group.

   • According to MIAO L (2023)

     Excerpt Male C57BL/6 mice had 14-week ad libitum access to a high-fat rodent diet containing 60% kcal% fat to induce obesity & diabetes whereas purslane extract (200 mg/kg/day) was administered during the last 4 weeks via intragastric gavage. This study supported that purslane protected endothelial function, & inhibited ER stress and oxidative stress in vasculature through AMPK/eNOS activation, revealing its therapeutic potential against vascular complications in diabetes.

   • According to Jalali J (2022)

     Excerpt This disorder is a significant risk factor for insulin resistance, diabetes mellitus, cardiovascular disease incidence, & mortality. Jalali J et al, Ameliorative effects of Portulaca oleracea L.

   • According to Rakhshandeh (2022)

     Excerpt Based on the anti-diabetic, antioxidant, & anti-hyperlipidemic potential of Portulaca oleracea (PO), this study aimed to evaluate the protective effect of this plant extract on streptozotocin-induced type-I-diabetes-associated reproductive system dysfunction & inflammation. Results: Our results showed that streptozotocin-induced diabetes significantly increased food & water consumption; increased glucose, MDA, TGF-β1, & TNF-α levels; & decreased the seminiferous tubules diameter, sperm count & motility, levels of LH, testosterone, total thiol, VEGF, & SOD activity.

   • According to Ebrahimian Z (2022)

     Excerpt MetS is the best-known risk factor for type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), & obesity. Portulaca oleracea L.

3. 3

   Bacterial infection: Pseudomonas aeruginosa, Salmonella Typhimurium, Proteus mirabilis, Klebsiella pneumoniae and Enterobacter aerogenes

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nayak BH (2014)

     Excerpt The apigenin so-obtained was subjected to antibacterial activity on five pathogenic bacterial strains like Pseudomonas aeruginosa, Salmonella Typhimurium, Proteus mirabilis, Klebsiella pneumoniae & Enterobacter aerogenes; among all the bacterial strains, S Typhimurium & P mirabilis have shown maximum diameter of inhibition zone for flavonoid & remaining bacterial strains have shown moderate diameter of inhibition zone when compared with control values & respectively. The minimum inhibition concentration (MIC) for the flavonoid for all tested bacterial strains was found to be >4 mg per mL.

   • According to WANG M (2023)

     Excerpt This article systematically reviews the extraction & purification methods, chemical structure, chemical modification, biological activity & other aspects of polysaccharides from purslane collected in the Chinese Pharmacopoeia, Flora of China, Web of Science, PubMed, Baidu Scholar, Google Scholar & CNKI databases in the last 14 years, using the keywords "Portulaca oleracea L. Portulaca oleracea L.

   • According to Author (2006)

     Excerpt Study on Antimicrobial Effect of Flavonoids from Portulaca oleracea L.

   • According to Liu G (2023)

     Excerpt Previous studies have shown that Portulaca oleracea L. In summary, this study reports a botanical extract that can inhibit SA in vitro & in vivo, indicating the potential use of OAPO to prevent and control SA infection in the near future.

   • According to Liu ZT (2023)

     Excerpt In this study, a response surface methodology was employed to optimize the extraction conditions for total flavonoids (TF) from Portulaca oleracea. Notably, the extracts obtained through ultrasound-assisted extraction exhibited higher total flavonoid content, antibacterial activity, and antioxidant activity compared to those obtained through conventional solvent extraction.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.