PROPOLIS (propolis) : medicinal properties in alcoholic extraction

PROPOLIS (propolis, Beeswax acid, Beeswax glue, Synthetic beeswax, Acide de cire d’Abeille, Colle d’Abeille, Cire d’abeille synthétique).

Scientific synonyms : -------.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 34 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 167 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hepatitis, cirrhosis, fatty liver

   Plant part used: Wax.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to BHADAURIA M (n.d.)

     Excerpt Histopathological studies of liver and kidney showed improved cellular architecture after propolis therapy & confirmed its hepatoprotective efficacy as a natural miracle. A 5-day treatment of propolis extract after toxicant administration reversed alterations in blood & tissue biochemical variables including liver function test and markers of oxidative stress almost as same as in silymarin-treated positive control.

   • According to Shinohara R (2002)

     Excerpt The antilipid peroxidative action of the ethanol extract of Brazilian propolis at a concentration of 47% (w/v) was evaluated by examining the inhibitory effect of the extract on the formation of hydroperoxide- & endoperoxide-type lipid peroxides during heating of authentic polyunsaturated fatty acids & on Fe(3+)-ADP/ascorbic acid- & Fe(3+)-ADP/NADPH-dependent lipid peroxidation reactions in rat liver microsomes. Propolis ethanol extract inhibited dose-dependently both Fe (3+)-ADP/ascorbic acid- & Fe (3+)-ADP/NADPH-dependent lipid peroxidation reactions in rat liver microsomes when lipid peroxides produced in both reactions were measured by the TBA method.

   • According to El Menyiy N (2018)

     Excerpt CONCLUSIONS: Propolis significantly prevented paracetamol induced renal, hepatic & hematological toxicity & might be useful in the management of liver & renal diseases particularly proteinuria. The purpose of this study was to investigate the beneficial effect of hydro-ethanolic extract of Propolis against paracetamol-induced liver damage & impairment of kidney function, as well as hematological changes in rats.

   • According to El Menyiy N (2016)

     Excerpt CONCLUSIONS: Propolis extract has a potential protective effect against ethylene glycol induced hepatotoxicity & nephrotoxicity & has a potential to treat & prevent urinary calculus, Crystaluria & proteinuria. The aim of the study is to evaluate the protective effect of Propolis extract on nephrotoxicity && hepatotoxicity induced by ethylene glycol in rats.

   • According to Selamoglu ZS (2015)

     Excerpt Selamoglu ZS et al, Antioxidant Effect of Ethanolic Extract of Propolis in Liver of L-NAME Treated Rats.

2. 2

   Cancer: adjuvant treatment of laryngeal carcinoma, breast cancer (whether hormone-dependent or not), prostate cancer, kidney cancer, bladder cancer, uterine cancer, mastocytoma and melanoma

   Plant part used: Wax.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ait Mouse H (2012)

     Excerpt For in vitro assays, three mammalian tumor cell lines were used: BSR (hamster renal adenocarcinoma), Hep-2 (human laryngeal carcinoma) & P815 (murin mastocytoma). On the other hand, oral route treatment of P815 tumor-bearing mice (DBA2/P815) with propolis ethanolic extract (5 mg per mouse every fourth day, five times for group A & 2.5 mg per mouse every fourth day, five times for group B) significantly reduced the tumor volume (1.2 cm3 for group A & 2.7 cm3 for group B at the 22nd day after tumor graft).

   • According to Buffalo MC (2009)

     Excerpt Buffalo MC et al, in vitro cytotoxic effect of Brazilian green Propolis on human laryngeal epidermoid carcinoma (HEp-2) cells, Evidence-Based Comp & Alternative Med, 6:483–487, 2009.

   • According to Zabalou N (2018)

     Excerpt Nous avons montré que : 1) Le stress oxydatif joue le rôle de promoteur dans le développement de l’HBP, 2) Le benzo(a)pyrène administré aux rats Wistar induit le développement du cancer de la prostate, 3) La propolis induit la diminution de la prolifération, de l’expression du Ki-67 (-49 %) et de l’expression de AhR chez le rat Wistar, 4) La propolis possède un effet antiprolifératif sur les cellules LNCaP via le blocage de la signalisation de AR. Notre but est d’étudier l’implication du stress oxydatif dans l’HBP et d’étudier l’effet de l’extrait de propolis sur le cancer de la prostate in vivo chez le rat Wistar et in vitro sur les cellules LNCaP.

   • According to Szliszka E (2013)

     Excerpt The aim of this study was to investigate the chemical composition & proapoptotic mechanism of ethanolic extract of Polish Propolis (EEP-P) against cancer cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays a significant role in immuno-surveillance and defense against cancer cells.

   • According to Kubina R (2015)

     Excerpt The multi-directional interactions among the various chemical compounds in Propolis seem to be the essential biological activities when considering its anticancer effects. The results showed that in case of Me45 & HCT 116 cell lines, the ethanol extract of Propolis could inhibit cell growth as well as cell size reduction.

3. 3

   Cancer chemoprevention: breast cancer (hormone-dependent or hormone-independent), colorectal and prostate cancer, oral squamous cell carcinoma

   Plant part used: Wax.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Szliszka E (2009)

     Excerpt Tumor necrosis factor related apoptosis inducing ligand (TRAIL) is a naturally occurring anticancer agent that preferentially induces apoptosis in cancer cells & is not toxic toward normal cells. In this report, we show for the first time that EEP markedly augmented TRAIL mediated apoptosis in cancer cells & confirmed the importance of propolis in chemoprevention of malignant tumors.

   • According to Szliszka E (2013)

     Excerpt These results suggest that EEP-P supports TRAIL-mediated Immuno-chemoprevention in prostate cancer cells. The aim of this study was to investigate the chemical composition & proapoptotic mechanism of ethanolic extract of Polish Propolis (EEP-P) against cancer cells.

   • According to Rzepecka-Stojko A (2015)

     Excerpt We evaluated the in vitro cytotoxic activity of ethanol extract of Propolis (EEP) & its derivative Caffeic acid Phenethyl ester (CAPE) towards two triple-negative breast cancer (TNBC) cell lines, MDA-MB-231 & Hs578T, by implementation of the MTT & lactate dehydrogenase (LDH) assays. EEP &, particularly, CAPE, may markedly affect the viability of breast cancer cells, suggesting the potential role of bioactive compounds in chemoprevention/ chemotherapy by potentiating the action of standard anti-cancer drugs.

   • According to Xiang D (2006)

     Excerpt These results indicate that CAPE is an excellent inhibitor of β-catenin/T-cell factor signaling in colon cancer cell lines & suggest that CAPE merits further study as an agent against colorectal cancers. Treatment of human colon cancer cells with apoptotic concentrations of CAPE resulted in a dose-dependent and time-dependent loss of total β-Catenin protein, associated with decreased nuclear β-catenin.

   • According to Zabalou N (2018)

     Excerpt Nous avons montré que : 1) Le stress oxydatif joue le rôle de promoteur dans le développement de l’HBP, 2) Le benzo(a)pyrène administré aux rats Wistar induit le développement du cancer de la prostate, 3) La propolis induit la diminution de la prolifération, de l’expression du Ki-67 (-49 %) et de l’expression de AhR chez le rat Wistar, 4) La propolis possède un effet antiprolifératif sur les cellules LNCaP via le blocage de la signalisation de AR. Notre but est d’étudier l’implication du stress oxydatif dans l’HBP et d’étudier l’effet de l’extrait de propolis sur le cancer de la prostate in vivo chez le rat Wistar et in vitro sur les cellules LNCaP.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.