Psidium guajava (Gouyav) : medicinal properties in alcoholic extraction

Psidium guajava (Gouyav, Goyave) — family Myrtacées.

Scientific synonyms : guajava pyrifera-(L)-Kuntze, Myrtus guajava-(L)-Kuntze, Psidium guava-Griseb, P guajava-Raddi, P pomiferum-L, P pumilum-Vahl, P pyriferum-L.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 47 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 234 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Jameson S (2023)

     Excerpt Guava (Psidium guajava L.) tree (Myrtaceae family) bears fruit rich in vitamins, fiber, & other nutrients. Guava has been shown to exhibit a number of biological & pharmacological activities, such as antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, antidiabetic, and anticancer properties.

   • According to LOK B (2023)

     Excerpt The fruits, leaves, & bark of the guava (Psidium guajava) tree have traditionally been used to treat a myriad of ailments, especially in the tropical and subtropical regions. The various parts of the plant have been shown to exhibit medicinal properties, such as antimicrobial, antioxidant, anti-inflammatory, & antidiabetic activities.

   • According to Lok B (2023)

     Excerpt 2023-Abstarct: The fruits, leaves, & bark of the guava (Psidium guajava) tree have traditionally been used to treat a myriad of ailments, especially in the tropical & subtropical regions. Lok B et al, The Anticancer Potential of Psidium guajava (Guava) Extracts, Life (Basel), 13(2):346.

   • According to Beidokhti MN (2015)

     Excerpt The ethanolic extracts were generally inactive against pancreatic α-amylase, & only bark extracts of Psidium guajava & Vangueria madagascariensis showed good activity with IC50 of 10.6 and 11.6 µg/mL, respectively. The aim of this study was to assess whether inhibition of α-glucosidase [1] & α-amylase [2] by ethanol extracts of 40 Madagascarian plants is the scientific rationale behind their traditional anti-diabetic use.

   • According to Lin CY (2012)

     Excerpt This study analyzed the content of phenolic acids & flavonoids in extracts of Psidium guajava fruit & examined the renal protective effects of guava aqueous extract (GAE) & ethanol extract (GEE) in diabetic mice. GAE or GEE intake at 2 % significantly reduced glucose & blood urea nitrogen levels, increased insulin level in plasma of diabetic mice (p < 0.05).

2. 2

   Cirrhosis, hepatitis, fatty liver disease

   Plant part used: Bud and young leaf (red variety).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2015)

     Excerpt Aqueous extract of Psidium guajava fruit was treated with 95% ethanol to collect the water-soluble polysaccharide precipitates. Therefore, the polysaccharide of PG possesses hepatoprotective activity & can be used as a dietary supplementation for protection of liver.

   • According to Menezes FNDD (2023)

     Excerpt This study evaluated whether by-products from industrial processing of acerola (Malpighia glabra L.; AB) & guava (Psidium guajava L.; GB) fruit may stimulate the growth and metabolism of probiotic Lactobacillus & Bifidobacterium & induce changes in human colonic microbiota.

   • According to Al-Marakby K (2026)

     Excerpt One of these fruits is guava (Psidium guajava), which is widely cultivated in humid & subtropical regions. They possess a diverse range of biological activities, including antioxidants, anti-flu, anti-cough, anti-inflammatory, hepatoprotective, antimicrobial, & antidiarrheal properties.

   • According to Uboh FE (2010)

     Excerpt This study considers the effects of aqueous extract of Psidium guajava leaves on the histology & biochemical indices of liver function as well as hematological indices in rats. Serum alanine aminotransferase (ALT), aspartate aminotransferase(AST), alkaline phosphatase (ALP), albumin & total protein levels, as well as the tissue histological assay are known to be useful in assessing the functional integrity of the liver.

   • According to SAMBO N (2009)

     Excerpt The effect of Psidium guajava extract on erythromycin-induced liver damage in albino rats was investigated using 30 normal rats grouped into six Group I & II served as the normal and treatment controls that were administered with normal saline and 100mg/kg body weight of erythromycin stearate daily for 14 days respectively. Histopathological investigation of the liver tissues revealed striking oedema & mild periportal mononuclear cell infiltration of hepatic cords in the liver of rats administered 100 mg/kg of erythromycin stearate & 300/450 mg/kg of PG extract.

3. 3

   Cancer: adjuvant treatment of carcinoma: colorectal, breast, prostate, lung and uterine

   Plant part used: Bud and young leaf (red variety).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lok B (2020)

     Excerpt To evaluate the anti-angiogenic & anticancer activities of Psidium guajava leaf extracts against angiogenesis-dependent colorectal cancer. Conclusions: The ethanol extract of P guajava has potential in the treatment of colorectal cancer through the inhibition of angiogenesis.

   • According to Lôk B (2019)

     Excerpt As they are rich in phenols, flavonoids & carotenoids, it is speculated that extracts from guava leaves may possess antiangiogenic activity & in turn, contain anticancer activity on colorectal cancer through their inhibition of angiogenesis. Psidium guajava (Guava) leaves had been traditionally used as a treatment for various ailments in tropical & subtropical countries.

   • According to LOK B (2023)

     Excerpt This review aims to present a concise summary of the in vitro & in vivo studies investigating the anticancer activity of the plant against various human cancer cell lines & animal models, including the identified phytochemicals that contributes to their activity via the different mechanisms. The fruits, leaves, & bark of the guava (Psidium guajava) tree have traditionally been used to treat a myriad of ailments, especially in the tropical and subtropical regions.

   • According to Lok B (2023)

     Excerpt Lok B et al, The Anticancer Potential of Psidium guajava (Guava) Extracts, Life (Basel), 13(2):346. This review aims to present a concise summary of the in vitro & in vivo studies investigating the anticancer activity of the plant against various human cancer cell lines & animal models, including the identified phytochemicals that contributes to their activity via the different mechanisms.

   • According to Lin CY (2012)

     Excerpt This study analyzed the content of phenolic acids & flavonoids in extracts of Psidium guajava fruit & examined the renal protective effects of guava aqueous extract (GAE) & ethanol extract (GEE) in diabetic mice. GAE or GEE treatments dose-dependently reserved glutathione content, retained activity of catalase & glutathione peroxidase & decreased reactive oxygen species, interleukin (IL)-6, tumor necrosis factor-α & IL-1β levels in kidney (p < 0.05).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.